Application of methylation in the diagnosis of ankylosing spondylitis.
Ankylosing spondylitis
Biological process
CPG island
Epigenetics
Methylation
Journal
Clinical rheumatology
ISSN: 1434-9949
Titre abrégé: Clin Rheumatol
Pays: Germany
ID NLM: 8211469
Informations de publication
Date de publication:
21 Aug 2024
21 Aug 2024
Historique:
received:
28
06
2024
accepted:
13
08
2024
revised:
12
08
2024
medline:
21
8
2024
pubmed:
21
8
2024
entrez:
21
8
2024
Statut:
aheadofprint
Résumé
Ankylosing spondylitis (AS) is a chronic inflammatory autoimmune disease, mainly characterized by perifibrocartilage osteitis of the sacroiliac joints and spinal enthesitis. To date, the exact pathogenesis of AS remains elusive. It is generally believed that AS is a multifactorial disease involving genetics, infection, environment, and immunity. Among them, genetic factors are the primary determinants of disease risk and severity. In recent years, epigenetic mechanisms such as DNA methylation have been extensively surveyed with respect to the pathogenesis of AS. This review summarizes the latest research progress of methylation in AS, from whole-genome sequencing to individual differentially methylated gene. And finally, the role of methylase in AS inflammation, autophagy, and osteogenic differentiation was explored. In summary, the results of this review attempt to explain the role of methylation in the occurrence and development of AS and point out the shortcomings of current methylation research, providing directions for subsequent methylation research in AS.
Identifiants
pubmed: 39167325
doi: 10.1007/s10067-024-07113-0
pii: 10.1007/s10067-024-07113-0
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : the National Natural Science Foundation of China
ID : 82205054
Organisme : the 2021 Open Fund of Anhui Provincial Key Laboratory of Applied Basic and Development Research in Modern Traditional Chinese Medicine
ID : 2021AKLMCM002
Organisme : Pharm-Bio Technology and Traditional Medicine Centre, Mbarara University of Science and Technology
ID : zyyzdxk-2023100
Informations de copyright
© 2024. The Author(s), under exclusive licence to International League of Associations for Rheumatology (ILAR).
Références
Landewé R, Braun J, Deodhar A, Dougados M, Maksymowych WP, Mease PJ et al (2014) Efficacy of certolizumab pegol on signs and symptoms of axial spondyloarthritis including ankylosing spondylitis: 24-week results of a double-blind randomised placebo-controlled phase 3 study. Ann Rheum Dis 73:39–47
pubmed: 24013647
Sieper J, Kivitz AJ, van Tubergen AM, Deodhar AA, Coteur G, Woltering F et al (2013) Rapid improvements in patient-reported outcomes with certolizumab pegol in patients with axial spondyloarthritis, including ankylosing spondylitis and non-radiographic axial spondyloarthritis: 24-week results of a phase 3 double-blind randomized placebo-controlled study. Value Health 16(Suppl):A227
Khan MA (1998) A worldwide overview: the epidemiology of HLA-B27 and associated spondyloarthritides. In: Calin A, Taurog JD (eds) The Spondyloarthritides. Oxford University Press, Oxford, UK, pp 17–26
Sheng N, Gao Y, Li H et al (2022) The associations of rs1799724 and rs361525 with the risk of ankylosing spondylitis are dependent on HLA-B27 status in a Chinese Han population. Front Immunol 13:852326. https://doi.org/10.3389/fimmu.2022.852326
pubmed: 35450075
pmcid: 9016113
Schlosstein L, Terasaki PI, Bluestone R, Pearson CM (1973) High association of an HL-A antigen, W27, with ankylosing spondylitis. N Engl J Med 288:704–706
pubmed: 4688372
Braun J, Sieper J (2007) Ankylosing spondylitis. Lancet 369:1379–1390
pubmed: 17448825
Hanson A, Brown MA (2017) Genetics and the causes of ankylosing spondylitis. Rheum Dis ClinNorth Am 43(3):401–414
Bilski R, Kamiński P, Kupczyk D, et al. (2024) Environmental and genetic determinants of ankylosing spondylitis. Int J Mol Sci. 25 (14) https://doi.org/10.3390/ijms25147814
Brown AC, Cohen CJ, Mielczarek O et al (2023) Comprehensive epigenomic profiling reveals the extent of disease-specific chromatin states and informs target discovery in ankylosing spondylitis. Cell Genom 3(6):100306. https://doi.org/10.1016/j.xgen.2023.100306
pubmed: 37388915
pmcid: 10300554
Whyte JM, Ellis JJ, Brown MA et al (2019) Best practices in DNA methylation: lessons from inflammatory bowel disease, psoriasis and ankylosing spondylitis. ARTHRITIS RES THER 21(1):133. https://doi.org/10.1186/s13075-019-1922-y
pubmed: 31159831
pmcid: 6547594
Nagase H, Ghosh S (2008) Epigenetics: differential DNA methylation in mammalian somatic tissues. FEBS J 275(8):1617–1623. https://doi.org/10.1111/j.1742-4658.2008.06330.x
Gutiérrez-Repiso C, Linares-Pineda TM, Gonzalez-Jimenez A et al (2021) Epigenetic biomarkers of transition from metabolically healthy obesity to metabolically unhealthy obesity phenotype: a prospective study. Int J Mol Sci. 22 (19) https://doi.org/10.3390/ijms221910417
Drabe M, Rullmann M, Luthardt J et al (2017) Serotonin transporter gene promoter methylation status correlates with in vivo prefrontal 5-HTT availability and reward function in human obesity. Transl Psychiatry 7(7):e1167. https://doi.org/10.1038/tp.2017.133
pubmed: 28675387
pmcid: 5538116
Perry RP, Kelley DE (1974) Existence of methylated messenger RNA in mouse L cells. Cell 1:37–42
Bokar JA, Shambaugh ME, Polayes D, Matera AG, Rottman FM (1997) Purification and cDNA cloning of the AdoMet- binding subunit of the humanmRNA (N6-adenosine)-methyltransferase. RNA 3:1233–1247
pubmed: 9409616
pmcid: 1369564
Zaccara S, Ries RJ, Jaffrey SR (2019) Reading, writing and erasing mRNA methylation. Nat Rev Mol Cell Biol 20(10):608–624. https://doi.org/10.1038/s41580-019-0168-5
pubmed: 31520073
Tan F, Zhao M, Xiong F, Wang Y, Guo C (2021) N6-methyladenosine-dependent signalling in cancer progression and insights into cancer therapies. J Exp Clin Cancer Res. 40(1):526. 6
Li Y, Xiao J, Bai J et al (2019) Molecular characterization and clinical relevance of m6A regulators across 33 cancer types. Mol Cancer 6(18):7
Huang J, Dong X, Gong Z et al (2019) Solution structure of the RNA recognition domain of METTL3-METTL14 N(6)-methyladenosine methyltransferase. Protein Cell 10(4):272–284
pubmed: 29542011
Wardowska A (2021) m6A RNA methylation in systemic autoimmune diseases-a new target for epigenetic-based therapy? Pharmaceuticals (Basel) 14(3):218. https://doi.org/10.3390/ph14030218
pubmed: 33807762
Kaastrup K, Gillberg L, Mikkelsen SU et al (2023) LEP promoter methylation in the initiation and progression of clonal cytopenia of undetermined significance and myelodysplastic syndrome. Clin Epigenetics 15(1):91. https://doi.org/10.1186/s13148-023-01505-w
pubmed: 37237325
pmcid: 10224308
Li W, Wang Y, Huang R et al (2022) Association of lipid metabolism-related gene promoter methylation with risk of coronary artery disease. Mol Biol Rep 49(10):9373–9378. https://doi.org/10.1007/s11033-022-07789-0
pubmed: 35941416
Wu J, Frazier K, Zhang J et al (2019) Emerging role of m6 A RNA methylation in nutritional physiology and metabolism. Obes Rev 21(1):e12942. https://doi.org/10.1111/obr.12942
pubmed: 31475777
pmcid: 7427634
Bongaarts A, Mijnsbergen C, Anink JJ et al (2021) Distinct DNA methylation patterns of subependymal giant cell astrocytomas in tuberous sclerosis complex. Cell Mol Neurobiol 42(8):2863–2892. https://doi.org/10.1007/s10571-021-01157-5
pubmed: 34709498
pmcid: 9560915
Brooks WH, Le Dantec C, Pers J-O, Youinou P, Renaudineau Y (2010) Epigenetics and autoimmunity. J Autoimmun 34(3):J207–J219
pubmed: 20053532
Hao J, Liu Y, Xu J, Wang W, Wen Y, He A, Fan Q, Guo X, Zhang F (2017) Genome-wide DNA methylation profile analysis identifies differentially methylatedloci associated with ankylosis spondylitis. Arthritis Res Ther 19:177
pubmed: 28743287
pmcid: 5526246
Yu T, Zhang J, Zhu W et al (2021) Chondrogenesis mediates progression of ankylosing spondylitis through heterotopic ossification. Bone Res 9(1):19. https://doi.org/10.1038/s41413-021-00140-6
pubmed: 33731675
pmcid: 7969928
Cortes A, Hadler J, Pointon JP et al (2013) Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci. Nat Genet. 45:730–8. https://doi.org/10.1038/ng.2667.5
pubmed: 23749187
pmcid: 3757343
Ellinghaus D, Jostins L, Spain SL et al (2016) Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci. Nat Genet 48:510–8. https://doi.org/10.1038/ng.3528
pubmed: 26974007
pmcid: 4848113
de la Calle-Fabregat C, Niemantsverdriet E, Cañete JD et al (2021) Prediction of the progression of undifferentiated arthritis to rheumatoid arthritis using DNA methylation profiling. Arthritis Rheumatol 73(12):2229–2239. https://doi.org/10.1002/art.41885
pubmed: 34105306
Howell KJ, Kraiczy J, Nayak KM et al (2018) DNA methylation and transcription patterns in intestinal epithelial cells from pediatric patients with inflammatory bowel diseases differentiate disease subtypes and associate with outcome. Gastroenterology 154(3):585–598. https://doi.org/10.1053/j.gastro.2017.10.007
pubmed: 29031501
Hao J, Liu Y, Xu J et al (2017) Genome-wide DNA methylation profile analysis identifies differentially methylated loci associated with ankylosis spondylitis. Arthritis Res Ther 19:177
pubmed: 28743287
pmcid: 5526246
Coit P, Kaushik P, Caplan L et al (2019) Genome-wide DNA methylation analysis in ankylosing spondylitis identifies HLA-B*27 dependent and independent DNA methylation changes in whole blood. J Autoimmun 102:126–132. https://doi.org/10.1016/j.jaut.2019.04.022
pubmed: 31128893
Xiao M, Zheng X, Li X et al (2022) Integrative blood-derived epigenetic and transcriptomic analysis reveals the potential regulatory role of DNA methylation in ankylosing spondylitis. Arthritis Res Ther 24(1):15. https://doi.org/10.1186/s13075-021-02697-3
pubmed: 34986893
pmcid: 8728943
Lebow MA, Schroeder M, Tsoory M et al (2019) Glucocorticoid-induced leucine zipper “quantifies” stressors and increases male susceptibility to PTSD. Transl Psychiatry 9(1):178. https://doi.org/10.1038/s41398-019-0509-3
pubmed: 31346158
pmcid: 6658561
van IJzendoorn MH,Caspers K,Bakermans-Kranenburg MJ, et al. (2010) Methylation matters: interaction between methylation density and serotonin transporter genotype predicts unresolved loss or trauma. Biol Psychiatry. 68 (5):405-7 https://doi.org/10.1016/j.biopsych.2010.05.008
Chen Y, Guan SY, Deng J, Yang H, Xu W, Xu S, Shao M, Gao X, Xu S, Shuai Z et al (2020) B7–H3:a promising therapeutic target for autoimmune diseases. Cell Immunol 352:104077
pubmed: 32113615
Zhou T, Wang X, Kong J et al (2023) PRICKLE1 gene methylation and abnormal transcription in Chinese patients with ankylosing spondylitis. Immunobiology 228(6):152742. https://doi.org/10.1016/j.imbio.2023.152742
pubmed: 37742487
Jiang D, He Y, Mo Q et al (2021) PRICKLE1, a Wnt/PCP signaling component, is overexpressed and associated with inferior prognosis in acute myeloid leukemia. J Transl Med. 19(1):211
pubmed: 34001134
pmcid: 8130533
Huang J, Song G, Yin Z et al (2019) Altered expression of microRNAs targeting Dkk-1 in peripheral blood mononuclear cells of patients with ankylosing spondylitis. Cent Eur J Immunol 44(1):59–64. https://doi.org/10.5114/ceji.2019.84018
pubmed: 31114438
pmcid: 6526586
Zou YC, Wang ZJ, Shao LC et al (2023) DNA methylation of DKK-1 may correlate with pathological bone formation in ankylosing spondylitis. Immun Inflamm Dis 11(7):e911. https://doi.org/10.1002/iid3.911
pubmed: 37506134
pmcid: 10326833
Ma Y,Fan D,Xu S, et al (2021) Ankylosing spondylitis patients display aberrant ERAP1 gene DNA methylation and expression. Immunol Invest. 1–13. https://doi.org/10.1080/08820139.2021.1982965
Liu SL, Zhou YM, Tang DB et al (2019) LGR6 promotes osteogenesis by activating the Wnt/β-catenin signaling pathway. Biochem Bioph Res Co 519(1):1–7. https://doi.org/10.1016/j.bbrc.2019.08.122
Cui Y, Huang R, Wang Y et al (2018) Down-regulation of LGR6 promotes bone fracture recovery using bone marrow stromal cells. Biomed Pharmacother 99:629–637. https://doi.org/10.1016/j.biopha.2017.12.109
pubmed: 29625528
Deng Y, Xu W, Ni M et al (2023) DNA methylation and expression of LGR6 gene in ankylosing spondylitis: a case-control study. Hum Immunol 84(12):110719. https://doi.org/10.1016/j.humimm.2023.09.005
pubmed: 37802707
Xu HJ, Liu XZ, Yang L et al (2023) Runx2 overexpression promotes bone repair of osteonecrosis of the femoral head (ONFH). Mol Biol Rep 50(6):4769–4779. https://doi.org/10.1007/s11033-023-08411-7
pubmed: 37029290
pmcid: 10209270
Wang F, Chen Y, Kong J et al (2023) Differences of RUNX2 gene promoter methylation and transcription level in ankylosing spondylitis. Int J Rheum Dis 26(12):2526–2533. https://doi.org/10.1111/1756-185X.14955
pubmed: 37902280
Jia, Y, Han, S, Li, J, et al. IRF8 is the target of SIRT1 for the inflammation response in macrophages. Innate immun-london. 2017; 23 innate immun-london. https://doi.org/10.1177/1753425916683751
Kurotaki D, Osato N, Nishiyama A et al (2013) Essential role of the IRF8-KLF4 transcription factor cascade in murine monocyte differentiation. Blood 121(10):1839–1849. https://doi.org/10.1182/blood-2012-06-437863
pubmed: 23319570
pmcid: 3591803
Ni M, Chen Y, Sun X et al (2022) DNA methylation and transcriptional profiles of IRF5 gene in ankylosing spondylitis: a case-control study. Int Immunopharmacol 110:109033. https://doi.org/10.1016/j.intimp.2022.109033
pubmed: 35810492
Chen M, Wu M, Hu X et al (2019) Ankylosing spondylitis is associated with aberrant DNA methylation of IFN regulatory factor 8 gene promoter region. Clin Rheumatol 38(8):2161–2169. https://doi.org/10.1007/s10067-019-04505-5
pubmed: 30900036
Zhang X, Lu J, Pan Z et al (2019) DNA methylation and transcriptome signature of the IL12B gene in ankylosing spondylitis. Int Immunopharmacol 71:109–114. https://doi.org/10.1016/j.intimp.2019.03.026
pubmed: 30889422
Zu Y, Yang Y, Zhu J et al (2016) MiR-146a suppresses hepatocellular carcinoma by downregulating TRAF6. Am J Cancer Res 6(11):2502–2513
pubmed: 27904767
pmcid: 5126269
Xu S, Gao X, Ma Y et al (2021) Association of methylation level and transcript level in TRAF5 gene with ankylosing spondylitis: a case-control study. Genes Immun 22(2):101–107. https://doi.org/10.1038/s41435-021-00135-7
pubmed: 34021268
Xu S, Pan Z, Huang L et al (2021) Association of FOXO3a gene polymorphisms and ankylosing spondylitis susceptibility in Eastern Chinese Han population. Gene. 800:145832. https://doi.org/10.1016/j.gene.2021.145832
pubmed: 34274476
Xu S, Zhang X, Wang X et al (2023) DNA methylation and transcription of the FOXO3a gene are associated with ankylosing spondylitis. Clin Exp Med 23(2):483–493. https://doi.org/10.1007/s10238-022-00831-2
pubmed: 35511319
Lai NS, Chou JL, Chen GC et al (2014) Association between cytokines and methylation of SOCS-1 in serum of patients with ankylosing spondylitis. Mol Biol Rep 41(6):3773–3780. https://doi.org/10.1007/s11033-014-3242-2
pubmed: 24532142
Andersson EI, Rajala HL, Eldfors S et al (2013) Novel somatic mutations in large granular lymphocytic leukemia affecting the STAT-pathway and T-cell activation. Blood Cancer J 3:e168. https://doi.org/10.1038/bcj.2013.65
pubmed: 24317090
pmcid: 3877422
Karami J, Mahmoudi M, Amirzargar A et al (2017) Promoter hypermethylation of BCL11B gene correlates with downregulation of gene transcription in ankylosing spondylitis patients. Genes Immun 18(3):170–175. https://doi.org/10.1038/gene.2017.17
pubmed: 28794504
Liu Y, Gao Y, Hao H et al (2020) CD279 mediates the homeostasis and survival of regulatory T cells by enhancing T cell and macrophage interactions. FEBS Open Bio 10(6):1162–1170. https://doi.org/10.1002/2211-5463.12865
pubmed: 32324337
pmcid: 7262947
Chen Y, Wu Y, Yang H et al (2022) DNA methylation and mRNA expression of B7–H3 gene in ankylosing spondylitis: a case-control study. Immunol Invest 51(7):2025–2034. https://doi.org/10.1080/08820139.2022.2095285
pubmed: 35786112
Wu Y, Chen Y, Sun X et al (2023) DNA methylation and transcriptome signatures of the PDCD1 gene in ankylosing spondylitis. Genes Immun 24(1):46–51. https://doi.org/10.1038/s41435-023-00196-w
pubmed: 36707702
Lei H et al (1996) De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells. Development 122:3195–3205
pubmed: 8898232
Aslani S, Mahmoudi M, Garshasbi M et al (2016) Evaluation of DNMT1 gene expression profile and methylation of its promoter region in patients with ankylosing spondylitis. Clin Rheumatol 35(11):2723–2731. https://doi.org/10.1007/s10067-016-3403-x
pubmed: 27637577
Wei H, Jiang S, Chen L et al (2017) Characterization of cytosine methylation and the DNA methyltransferases of Toxoplasma gondii. Int J Biol Sci 13(4):458–470. https://doi.org/10.7150/ijbs.18644
pubmed: 28529454
pmcid: 5436566
Shen B, Mode NA, NorenHooten N et al (2023) Association of race and poverty status with DNA methylation-based age. JAMA Netw Open 6(4):e236340. https://doi.org/10.1001/jamanetworkopen.2023.6340
pubmed: 37027157
pmcid: 10082406
Zhong Z, Feng X, Su G et al (2021) HMG-coenzyme A reductase as a drug target for the prevention of ankylosing spondylitis. Front Cell Dev Biol 9:731072. https://doi.org/10.3389/fcell.2021.731072
pubmed: 34692687
pmcid: 8526849
Taurog JD (2007) The mystery of HLA-B27: If it isn’t one thing, it’s another. Arthritis Rheum 56:2478–2481
pubmed: 17665431
Zhang L, Cao R, Li D et al (2021) Ethionine-mediated reduction of S-adenosylmethionine is responsible for the neural tube defects in the developing mouse embryo-mediated m6A modification and is involved in neural tube defects via modulating Wnt/β-catenin signaling pathway. Epigenetics Chromatin 14(1):52. https://doi.org/10.1186/s13072-021-00426-3
pubmed: 34863249
pmcid: 8645112
Lai NS, Yu HC, Chen HC, Yu CL, Huang HB, Lu MC (2013) Aberrant expression of microRNAs in T cells from patients with ankylosing spondylitis contributes to the immunopathogenesis. Clin Exp Immunol 173:47–57
pubmed: 23607629
pmcid: 3694534
Gökmen F, Akbal A, Reşorlu H et al (2014) Neutrophil-lymphocyte ratio connected to treatment options and inflammation markers of ankylosing spondylitis. J Clin Lab Anal 29(4):294–298. https://doi.org/10.1002/jcla.21768
pubmed: 24849656
pmcid: 6807178
Feng Z, Li Q, Meng R et al (2018) METTL3 regulates alternative splicing of MyD88 upon the lipopolysaccharide-induced inflammatory response in human dental pulp cells. J Cell Mol Med 22(5):2558–2568. https://doi.org/10.1111/jcmm.13491
pubmed: 29502358
pmcid: 5908103
Wang J, Yan S, Hongying Lu et al (2019) METTL3 attenuates LPS-induced inflammatory response in macrophages via NF-κB signaling pathway. Mediators Inflamm 2019:1–8. https://doi.org/10.1155/2019/3120391
Qing Luo,Yongqin Guo,Qiuyun Xiao, et al. (2022) Expression and clinical significance of the m6A RNA-binding proteins YTHDF2 in peripheral blood mononuclear cells from new-onset ankylosing spondylitis. Front Med. 9 (0):0–0. https://doi.org/10.3389/fmed.2022.922219
Hu LF (2019) Epigenetic regulation of autophagy. Adv Exp Med Biol 1206:221–236. https://doi.org/10.1007/978-981-15-0602-4_11
pubmed: 31776988
Park MC, Kim HW, Lee SW et al (2016) Defective autophagy activity and its association with spinal damage in patients with ankylosing spondylitis. Joint Bone Spine 84(5):583–587. https://doi.org/10.1016/j.jbspin.2016.09.005
pubmed: 27825566
Lin L, Zhao Y, Zheng Q et al (2023) Epigenetic targeting of autophagy for cancer: DNA and RNA methylation. Front Oncol 13:1290330. https://doi.org/10.3389/fonc.2023.1290330)
pubmed: 38148841
pmcid: 10749975
Ciccia F, Haroon N (2016) Autophagy in the pathogenesis of ankylosing spondylitis. Clin Rheumatol 35(6):1433–1436. https://doi.org/10.1007/s10067-016-3262-5
pubmed: 27075464
Chen Y, Wu Y, Fang L et al (2023) METTL14-m6A-FOXO3a axis regulates autophagy and inflammation in ankylosing spondylitis. Clin Immunol 257:109838. https://doi.org/10.1016/j.clim.2023.109838
pubmed: 37935312
Wang W, Qiao SC, Wu XB et al (2021) Circ_0008542 in osteoblast exosomes promotes osteoclast-induced bone resorption through m6A methylation. Cell Death Dis 12(7):628
pubmed: 34145224
pmcid: 8213782
Liu CH et al (2019) HLA-B27-mediated activation of TNAP phosphatase promotes pathogenic syndesmophyte formation in ankylosing spondylitis. J Clin Invest 129:5357–5373
pubmed: 31682238
pmcid: 6877322
Xie Z, Yu W, Zheng G et al (2021) TNF-α-mediated m 6 A modification of ELMO1 triggers directional migration of mesenchymal stem cell in ankylosing spondylitis. Nat Commun 12(1):5373. https://doi.org/10.1038/s41467-021-25710-4
pubmed: 34508078
pmcid: 8433149
He M, Lei H, He X et al (2022) METTL14 regulates osteogenesis of bone marrow mesenchymal stem cells via inducing autophagy through m6A/IGF2BPs/Beclin-1 signal axis. Stem Cells Transl Med 11(9):987–1001. https://doi.org/10.1093/stcltm/szac049
pubmed: 35980318
pmcid: 9492283
Huang D, Wang Y, He Y et al (2018) Paraoxonase 3 is involved in the multi-drug resistance of esophageal cancer. Cancer Cell Int 18:168. https://doi.org/10.1186/s12935-018-0657-1
pubmed: 30386177
pmcid: 6198441
Song D, Zhou Z, Wu J et al (2022) DNA methylation regulators-related molecular patterns and tumor immune landscape in hepatocellular carcinoma. Front Oncol 12:877817. https://doi.org/10.3389/fonc.2022.877817Chatterjee
pubmed: 36091162
pmcid: 9459088
A, Bararia A, Ganguly D, et al (2022) DNA methylome in pancreatic cancer identified novel promoter hyper-methylation in NPY and FAIM2 genes associated with poor prognosis in Indian patient cohort. Cancer Cell Int. ;22 (1):33410.1186/s12935-022-02737-1
Lee S, Kang S, Eun Y et al (2021) A cluster analysis of patients with axial spondyloarthritis using tumour necrosis factor alpha inhibitors based on clinical characteristics. Arthritis Res Ther 23(1):284. https://doi.org/10.1186/s13075-021-02647-z
pubmed: 34782006
pmcid: 8591959
Gao J, Zhang G, Xu K et al (2020) Bone marrow mesenchymal stem cells improve bone erosion in collagen-induced arthritis by inhibiting osteoclasia-related factors and differentiating into chondrocytes. Stem Cell Res Ther 11(1):171. https://doi.org/10.1186/s13287-020-01684-w
pubmed: 32381074
pmcid: 7203805