Inhibitory effects of extracts from Eucalyptus gunnii on α-synuclein amyloid fibrils.

Amyloid fibril formation Eucalyptus Plant extracts Polyphenol α-synuclein

Journal

Bioscience, biotechnology, and biochemistry
ISSN: 1347-6947
Titre abrégé: Biosci Biotechnol Biochem
Pays: England
ID NLM: 9205717

Informations de publication

Date de publication:
21 Aug 2024
Historique:
medline: 22 8 2024
pubmed: 22 8 2024
entrez: 22 8 2024
Statut: aheadofprint

Résumé

Amyloid fibril formation is associated with various amyloidoses, including neurodegenerative diseases such as Alzheimer's and Parkinson's diseases. Despite the numerous studies on the inhibition of amyloid formation, the prevention and treatment of a majority of amyloid-related disorders are still challenging. In this study, we investigated the effects of various plant extracts on amyloid formation of α-synuclein. We found that the extracts from Eucalyptus gunnii are able to inhibit amyloid formation, and to disaggregate preformed fibrils, in vitro. The extract itself did not lead cell damage. In the extract, miquelianin, which is a glycosylated form of quercetin and has been detected in the plasma and the brain, was identified and assessed to have a moderate inhibitory activity, compared to the effects of ellagic acid and quercetin, which are strong inhibitors for amyloid formation. The properties of miquelianin provide insights into the mechanisms controlling the assembly of α-synuclein in the brain.

Identifiants

DOI: 10.1093/bbb/zbae114 PMID: 39169473
pubmed: 39169473
pii: 7738380
doi: 10.1093/bbb/zbae114
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© The Author(s) 2024. Published by Oxford University Press on behalf of Japan Society for Bioscience, Biotechnology, and Agrochemistry.

Auteurs

Masatomo So (M)

Graduate School of Agriculture, Kyoto University, Kitashirakawa Oiwake-cho, Sakyo-ku, Kyoto 606-8502, Japan.
Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Suita-shi, Osaka 565-0871, Japan.
ORCID: 0000-0002-4815-4995

Misaki Ono (M)

Department of Nutritional Sciences, Faculty of Nutritional Sciences, Nakamura Gakuen University, 5-7-1 Befu, Jonan-ku, Fukuoka 814-0198, Japan.

Shigeki Oogai (S)

Saga Food & Cosmetic Laboratory, Saga Prefectural Industrial Innovation Center, 114 Yaemizo, Nabeshima-cho, Saga 849-0932, Japan.

Minako Kondo (M)

ARFS, Hamamatsu University School of Medicine, 1-20-1 Handayama, Chuo-ku, Hamamatsu, Shizuoka 431-3192 Japan.

Kaede Yamazaki (K)

Saga Food & Cosmetic Laboratory, Saga Prefectural Industrial Innovation Center, 114 Yaemizo, Nabeshima-cho, Saga 849-0932, Japan.

Charlotte Nachtegael (C)

Interuniversity Institute of Bioinformatics in Brussels, Université Libre de Bruxelles-Vrije Universiteit Brussel, ULB-VUB, La Plaine Campus, Triomflaan, C building, 6th floor, CP 263 1050 Brussels, Belgium.
Machine Learning Group, Université Libre de Bruxelles, Campus de la Plaine, NO8, CP212 Brussels, Belgium.

Hiroshi Hamajima (H)

Saga Food & Cosmetic Laboratory, Saga Prefectural Industrial Innovation Center, 114 Yaemizo, Nabeshima-cho, Saga 849-0932, Japan.

Risa Mutoh (R)

Department of Applied Physics, Faculty of Science, Fukuoka University, 8-19-1, Nanakuma, Jonan-ku, Fukuoka city, Fukuoka 814-0180, Japan.

Masaki Kato (M)

Department of Nutritional Sciences, Faculty of Nutritional Sciences, Nakamura Gakuen University, 5-7-1 Befu, Jonan-ku, Fukuoka 814-0198, Japan.
Graduate School of Nutritional Sciences, Nakamura Gakuen University, 5-7-1 Befu, Jonan-ku, Fukuoka 814-0198, Japan.

Hisaya Kawate (H)

Department of Nutritional Sciences, Faculty of Nutritional Sciences, Nakamura Gakuen University, 5-7-1 Befu, Jonan-ku, Fukuoka 814-0198, Japan.
Graduate School of Nutritional Sciences, Nakamura Gakuen University, 5-7-1 Befu, Jonan-ku, Fukuoka 814-0198, Japan.

Tomoyuki Oki (T)

Department of Nutritional Sciences, Faculty of Nutritional Sciences, Nakamura Gakuen University, 5-7-1 Befu, Jonan-ku, Fukuoka 814-0198, Japan.
Graduate School of Nutritional Sciences, Nakamura Gakuen University, 5-7-1 Befu, Jonan-ku, Fukuoka 814-0198, Japan.

Yasushi Kawata (Y)

Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University, 4-101 Koyama Minami, Tottori 680-8552, Japan.

Shiho Kumamoto (S)

Department of Nutritional Sciences, Faculty of Nutritional Sciences, Nakamura Gakuen University, 5-7-1 Befu, Jonan-ku, Fukuoka 814-0198, Japan.

Noritaka Tokui (N)

Department of Nutritional Sciences, Faculty of Nutritional Sciences, Nakamura Gakuen University, 5-7-1 Befu, Jonan-ku, Fukuoka 814-0198, Japan.
Graduate School of Nutritional Sciences, Nakamura Gakuen University, 5-7-1 Befu, Jonan-ku, Fukuoka 814-0198, Japan.
Institute of Preventive and Medical Dietetics, Nakamura Gakuen University, 5-7-1 Befu, Jonan-ku, Fukuoka 814-0198, Japan.

Toshiki Takei (T)

Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Suita-shi, Osaka 565-0871, Japan.

Kuniyoshi Shimizu (K)

Department of Agro-Environmental Sciences, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan.
ORCID: 0000-0001-5960-1503

Akio Inoue (A)

Human Brain Research Center, Graduate School of Medicine, Kyoto University, 54 Shogoinnkawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.

Naoki Yamamoto (N)

Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, Texas 75390, USA.

Motoko Unoki (M)

Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
ORCID: 0000-0002-9629-3818

Kenichi Tanabe (K)

Department of Nutritional Sciences, Faculty of Nutritional Sciences, Nakamura Gakuen University, 5-7-1 Befu, Jonan-ku, Fukuoka 814-0198, Japan.
Graduate School of Nutritional Sciences, Nakamura Gakuen University, 5-7-1 Befu, Jonan-ku, Fukuoka 814-0198, Japan.
Institute of Preventive and Medical Dietetics, Nakamura Gakuen University, 5-7-1 Befu, Jonan-ku, Fukuoka 814-0198, Japan.

Kinichi Nakashima (K)

Stem Cell Biology and Medicine, Department of Stem Cell Biology and Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

Hiroyuki Sasaki (H)

Division of Epigenomics and Development, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

Hironobu Hojo (H)

Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Suita-shi, Osaka 565-0871, Japan.

Yasuo Nagata (Y)

Saga Food & Cosmetic Laboratory, Saga Prefectural Industrial Innovation Center, 114 Yaemizo, Nabeshima-cho, Saga 849-0932, Japan.

Isao Suetake (I)

Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Suita-shi, Osaka 565-0871, Japan.
Department of Nutritional Sciences, Faculty of Nutritional Sciences, Nakamura Gakuen University, 5-7-1 Befu, Jonan-ku, Fukuoka 814-0198, Japan.
Graduate School of Nutritional Sciences, Nakamura Gakuen University, 5-7-1 Befu, Jonan-ku, Fukuoka 814-0198, Japan.
Institute of Preventive and Medical Dietetics, Nakamura Gakuen University, 5-7-1 Befu, Jonan-ku, Fukuoka 814-0198, Japan.
Division of Epigenomics and Development, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
ORCID: 0000-0002-1246-8474

Classifications MeSH