Oligoarginine peptide structure and its effect on cell penetration in ocular drug delivery.

Antibacterial Cell-penetrating peptides Ocular drug delivery Oligoarginine

Journal

Heliyon
ISSN: 2405-8440
Titre abrégé: Heliyon
Pays: England
ID NLM: 101672560

Informations de publication

Date de publication:
15 Aug 2024
Historique:
received: 02 02 2024
revised: 14 05 2024
accepted: 23 07 2024
medline: 22 8 2024
pubmed: 22 8 2024
entrez: 22 8 2024
Statut: epublish

Résumé

Oligoarginine cell-penetrating peptides (CPPs) are short peptides that can enhance drug delivery into cells and are of particular interest in ocular topical formulations for age-related macular degeneration (AMD) treatments. The length and structural characteristics of these peptides are considered crucial for drug delivery. This study investigates how oligoarginine length (R

Identifiants

pubmed: 39170441
doi: 10.1016/j.heliyon.2024.e35109
pii: S2405-8440(24)11140-1
pmc: PMC11336422
doi:

Types de publication

Journal Article

Langues

eng

Pagination

e35109

Informations de copyright

© 2024 The Authors.

Déclaration de conflit d'intérêts

We have no conflicts of interest either financial or in any other way with regards to this work.

Auteurs

Stefana Duca (S)

School of Pharmacy, University of Nottingham, Nottingham, UK.

Naa Dei Nikoi (ND)

School of Pharmacy, University of Nottingham, Nottingham, UK.

Madeline Berrow (M)

School of Pharmacy, University of Nottingham, Nottingham, UK.

Lois Barber (L)

Institute of Microbiology and Infection, University of Birmingham, Birmingham, UK.

Louise N Slope (LN)

School of Chemistry, University of Birmingham, Birmingham, UK.

Anna F A Peacock (AFA)

School of Chemistry, University of Birmingham, Birmingham, UK.

Felicity de Cogan (F)

School of Pharmacy, University of Nottingham, Nottingham, UK.

Classifications MeSH