Navigating the Challenges of Factor X Deficiency: A Case Study.

autosomal recessive disorders bleeding risk factor x deficiency hemophilia b hemophilia-a pt-inr

Journal

Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737

Informations de publication

Date de publication:
Jul 2024
Historique:
received: 17 05 2024
accepted: 21 07 2024
medline: 22 8 2024
pubmed: 22 8 2024
entrez: 22 8 2024
Statut: epublish

Résumé

The clotting pathway involves intrinsic and extrinsic pathways converging into a common pathway. These pathways require activated factors that sequentially convert prothrombin to thrombin, which then converts fibrinogen to fibrin, forming a stable clot. Clotting factor deficiency impairs this cascade leading to excessive bleeding or bruising due to insufficient clot formation. Here, we present the case of a 47-year-old female who initially complained of epigastric pain. By the third day of admission, she experienced four to five episodes of bleeding gums, resulting in a blood loss of approximately 300 mL. The patient exhibited abnormal prothrombin time (PT) and international normalized ratio (INR) values, leading to a diagnosis of Factor X (FX) deficiency upon further evaluation. This case report emphasizes the need to diagnose coagulopathies such as FX deficiency and how early diagnosis will help not only in patient care and management but also in screening family members who may be affected.

Identifiants

pubmed: 39171054
doi: 10.7759/cureus.65084
pmc: PMC11336509
doi:

Types de publication

Case Reports Journal Article

Langues

eng

Pagination

e65084

Informations de copyright

Copyright © 2024, Chaudhary et al.

Déclaration de conflit d'intérêts

Human subjects: Consent was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

Auteurs

Gaurav A Chaudhary (GA)

General Medicine, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Pune, IND.

Harin M Bhavsar (HM)

General Medicine, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Pune, IND.

Madhulika L Mahashabde (ML)

General Medicine, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Pune, IND.

Classifications MeSH