Causal factors for osteoarthritis risk revealed by mendelian randomization analysis.
Causality
Genetics
Mendelian randomization
Osteoarthritis
Journal
Aging clinical and experimental research
ISSN: 1720-8319
Titre abrégé: Aging Clin Exp Res
Pays: Germany
ID NLM: 101132995
Informations de publication
Date de publication:
22 Aug 2024
22 Aug 2024
Historique:
received:
29
04
2024
accepted:
15
07
2024
medline:
22
8
2024
pubmed:
22
8
2024
entrez:
22
8
2024
Statut:
epublish
Résumé
Osteoarthritis (OA), a prevalent chronic disease among the elderly, presents a complex pathogenesis and currently lacks effective treatment. Traditional observational studies are time-consuming, labor-intensive, susceptible to confounding factors, and cannot establish causal relationships. Mendelian randomization (MR) analysis, leveraging genetic variation to assess causal associations between exposures and outcomes, offers a cost-effective and efficient alternative. Over the past decade, large-scale genome-wide association studies have identified numerous genetic variants linked to OA risk factors, facilitating MR study design. In this review, we systematically identified 52 MR studies meeting specific criteria and evaluated their quality, exploring the impact of lifestyle, nutrition, comorbidities, circulating metabolites, plasma proteins, and other health factors on OA risk. We discuss the results and potential mechanisms of MR findings, addressing conflicting evidence based on existing literature and our prior research. With the ongoing expansion of genome-wide association data, we anticipate MR's role in future OA studies to broaden, particularly in drug development research using targeted MR approaches. We thus aim for this paper to offer valuable insights for researchers and clinicians in related fields.
Identifiants
pubmed: 39172202
doi: 10.1007/s40520-024-02812-9
pii: 10.1007/s40520-024-02812-9
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
176Subventions
Organisme : the Program for Youth Innovation in Future Medicine, Chongqing Medical University
ID : no.w0155
Organisme : the Natural Science Foundation of Chongqing
ID : no. 2023NSCQ-MSX0742
Informations de copyright
© 2024. The Author(s).
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