Response to chronic sustained hypoxia: increased cytosolic gelsolin and decreased plasma gelsolin levels.
Apoptosis
Chronic sustained hypoxia
Cytosolic gelsolin
HIF-1
Oxidative stress
Plasma gelsolin
Journal
Journal of molecular histology
ISSN: 1567-2387
Titre abrégé: J Mol Histol
Pays: Netherlands
ID NLM: 101193653
Informations de publication
Date de publication:
22 Aug 2024
22 Aug 2024
Historique:
received:
19
12
2023
accepted:
14
08
2024
medline:
22
8
2024
pubmed:
22
8
2024
entrez:
22
8
2024
Statut:
aheadofprint
Résumé
An actin binding protein, gelsolin (GSN) has two isoforms, plasma (pGSN) and cytosolic (cGSN). Changes in pGSN and/or cGSN levels have been shown to be associated with the pathogenesis of several diseases. The aim of this study was to evaluate changes in intracellular and extracellular GSNlevels with HIF-1 in animals exposed to chronic sustained hypoxia (CSH), in addition to apoptosis and the cellular redox status. The rats in the Sham group were exposed to 21% O
Identifiants
pubmed: 39172327
doi: 10.1007/s10735-024-10248-8
pii: 10.1007/s10735-024-10248-8
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer Nature B.V.
Références
Agustí A, Vogelmeier C, Faner R (2020) COPD 2020: changes and challenges. Am J Physiol-Lung Cell Mol Physiol 319:L879–L883. https://doi.org/10.1152/ajplung.00429.2020
doi: 10.1152/ajplung.00429.2020
pubmed: 32964724
Asare-Werehene M, Nakka K, Reunov A et al (2020) The exosome-mediated autocrine and paracrine actions of plasma gelsolin in ovarian cancer chemoresistance. Oncogene 39:1600–1616. https://doi.org/10.1038/s41388-019-1087-9
doi: 10.1038/s41388-019-1087-9
pubmed: 31700155
Barnes LA, Mesarwi OA, Sanchez-Azofra A (2022) The cardiovascular and metabolic effects of chronic hypoxia in animal models: a mini-review. Front Physiol 13:873522–873522. https://doi.org/10.3389/fphys.2022.873522
doi: 10.3389/fphys.2022.873522
pubmed: 35432002
pmcid: 9008331
Bianciardi P, Fantacci M, Caretti A et al (2006) Chronic in vivo hypoxia in various organs: hypoxia-inducible factor-1α and apoptosis. Biochem Biophys Res Commun 342:875–880. https://doi.org/10.1016/j.bbrc.2006.02.042
doi: 10.1016/j.bbrc.2006.02.042
pubmed: 16596722
Chauhan V, Ji L, Chauhan A (2008) Anti-amyloidogenic, anti-oxidant and anti-apoptotic role of gelsolin in Alzheimer’s disease. Biogerontology 9:381–389. https://doi.org/10.1007/s10522-008-9169-z
doi: 10.1007/s10522-008-9169-z
pubmed: 18704746
Corrado C, Fontana S (2020) Hypoxia and HIF signaling: one axis with divergent effects. Int J Mol Sci 21:5611. https://doi.org/10.3390/ijms21165611
doi: 10.3390/ijms21165611
pubmed: 32764403
pmcid: 7460602
Delbrel E, Soumare A, Naguez A et al (2018) HIF-1α triggers ER stress and CHOP-mediated apoptosis in alveolar epithelial cells, a key event in pulmonary fibrosis. Sci Rep 8:17939–17939. https://doi.org/10.1038/s41598-018-36063-2
doi: 10.1038/s41598-018-36063-2
pubmed: 30560874
pmcid: 6299072
Deng R, Hao J, Han W et al (2015) Gelsolin regulates proliferation, apoptosis, migration and invasion in human oral carcinoma cells. Oncol Lett 9:2129–2134. https://doi.org/10.3892/ol.2015.3002
doi: 10.3892/ol.2015.3002
pubmed: 26137026
pmcid: 4467278
Endres M, Fink K, Zhu J et al (1999) Neuroprotective effects of gelsolin during murine stroke. J Clin Invest 103:347–354. https://doi.org/10.1172/JCI4953
doi: 10.1172/JCI4953
pubmed: 9927495
pmcid: 407902
Fan J, Lv H, Li J et al (2018) Roles of Nrf2/HO-1 and HIF-1α/VEGF in lung tissue injury and repair following cerebral ischemia/reperfusion injury. J Cell Physiol 234:7695–7707. https://doi.org/10.1002/jcp.27767
doi: 10.1002/jcp.27767
pubmed: 30565676
Feldt J, Schicht M, Garreis F et al (2019) Structure, regulation and related diseases of the actin-binding protein gelsolin. Expert Rev Mol Med 20:e7. https://doi.org/10.1017/erm.2018.7
doi: 10.1017/erm.2018.7
pubmed: 30698126
Fitzpatrick CM, Shi Y, Hutchins WC et al (2005) Cardioprotection in chronically hypoxic rabbits persists on exposure to normoxia: role of NOS and KATP channels. Am J Physiol Heart Circ Physiol 288:H62–H68. https://doi.org/10.1152/ajpheart.00701.2004
doi: 10.1152/ajpheart.00701.2004
pubmed: 15319200
García-Bartolomé A, Peñas A, Marín-Buera L et al (2017) Respiratory chain enzyme deficiency induces mitochondrial location of actin-binding gelsolin to modulate the oligomerization of VDAC complexes and cell survival. Hum Mol Genet 26:2493–2506. https://doi.org/10.1093/hmg/ddx144
doi: 10.1093/hmg/ddx144
pubmed: 28431142
pmcid: 6192415
García-Bartolomé A, Peñas A, Illescas M et al (2020) Altered expression ratio of actin-binding gelsolin isoforms is a novel hallmark of mitochondrial OXPHOS dysfunction. Cells 9:1922. https://doi.org/10.3390/cells9091922
doi: 10.3390/cells9091922
pubmed: 32824961
pmcid: 7563380
Greijer A, van der Groep P, Kemming D et al (2005) Up-regulation of gene expression by hypoxia is mediated predominantly by hypoxia-inducible factor 1 (HIF-1). J Pathol 206:291–304. https://doi.org/10.1002/path.1778
doi: 10.1002/path.1778
pubmed: 15906272
Horváth-Szalai Z, Kustán P, Szirmay B et al (2018) Predictive value of serum gelsolin and Gc globulin in sepsis: a pilot study. Clin Chem Lab Med 56:1373–1382. https://doi.org/10.1515/cclm-2017-0782
doi: 10.1515/cclm-2017-0782
pubmed: 29320362
Illescas M, Peñas A, Arenas J et al (2021) Regulation of mitochondrial function by the actin cytoskeleton. Front Cell Dev Biol 9:795838–795838. https://doi.org/10.3389/fcell.2021.795838
doi: 10.3389/fcell.2021.795838
pubmed: 34993202
pmcid: 8725978
Kasparova D, Neckar J, Dabrowska L et al (2015) Cardioprotective and nonprotective regimens of chronic hypoxia diversely affect the myocardial antioxidant systems. Physiol Genom 47:612–620. https://doi.org/10.1152/physiolgenomics.00058.2015
doi: 10.1152/physiolgenomics.00058.2015
Ke Q, Costa M (2006) Hypoxia-inducible factor-1 (HIF-1). Mol Pharmacol 70:1469–1480. https://doi.org/10.1124/mol.106.027029
doi: 10.1124/mol.106.027029
pubmed: 16887934
Kim R, An S, Gwark J, Park H (2021) Antioxidant effects on hypoxia-induced oxidative stress and apoptosis in rat rotator cuff fibroblasts. Eur Cells Mater 41:680–693. https://doi.org/10.22203/ecm.v041a44
doi: 10.22203/ecm.v041a44
Korbecki J, Simińska D, Gąssowska-Dobrowolska M et al (2021) Chronic and cycling hypoxia: drivers of cancer chronic inflammation through HIF-1 and NF-κB activation—a review of the molecular mechanisms. Int J Mol Sci 22:10701. https://doi.org/10.3390/ijms221910701
doi: 10.3390/ijms221910701
pubmed: 34639040
pmcid: 8509318
Koya RC, Fujita H, Shimizu S et al (2000) Gelsolin inhibits apoptosis by blocking mitochondrial membrane potential loss and cytochrome c release. J Biol Chem 275:15343–15349. https://doi.org/10.1074/jbc.275.20.15343
doi: 10.1074/jbc.275.20.15343
pubmed: 10809769
Kusano H, Shimizu S, Koya RC et al (2000) Human gelsolin prevents apoptosis by inhibiting apoptotic mitochondrial changes via closing VDAC. Oncogene 19:4807–4814. https://doi.org/10.1038/sj.onc.1203868
doi: 10.1038/sj.onc.1203868
pubmed: 11039896
Leifeld L, Fink K, Debska G et al (2006) Anti-apoptotic function of gelsolin in fas antibody-induced liver failure in vivo. Am J Pathol 168:778–785. https://doi.org/10.2353/ajpath.2006.050323
doi: 10.2353/ajpath.2006.050323
pubmed: 16507893
pmcid: 1606525
Li GH, Shi Y, Chen Y et al (2009) Gelsolin regulates cardiac remodeling after myocardial infarction through DNase I-mediated apoptosis. Circ Res 104:896–904. https://doi.org/10.1161/circresaha.108.172882
doi: 10.1161/circresaha.108.172882
pubmed: 19246681
Li W-X, Yang M-X, Hong X-Q et al (2016) Overexpression of gelsolin reduces the proliferation and invasion of colon carcinoma cells. Mol Med Rep 14:3059–3065. https://doi.org/10.3892/mmr.2016.5652
doi: 10.3892/mmr.2016.5652
pubmed: 27573444
pmcid: 5042772
Liao C-J, Wu T-I, Huang Y-H et al (2011) Overexpression of gelsolin in human cervical carcinoma and its clinicopathological significance. Gynecol Oncol 120:135–144. https://doi.org/10.1016/j.ygyno.2010.10.005
doi: 10.1016/j.ygyno.2010.10.005
pubmed: 21035170
Malkmus K, Brosien M, Knoepp F et al (2022) Deletion of classical transient receptor potential 1, 3 and 6 alters pulmonary vasoconstriction in chronic hypoxia-induced pulmonary hypertension in mice. Front Physiol 13:1080875–1080875. https://doi.org/10.3389/fphys.2022.1080875
doi: 10.3389/fphys.2022.1080875
pubmed: 36569761
pmcid: 9768328
Mateos J, Lourido L, Fernández-Puente P et al (2012) Differential protein profiling of synovial fluid from rheumatoid arthritis and osteoarthritis patients using LC–MALDI TOF/TOF. J Proteom 75:2869–2878. https://doi.org/10.1016/j.jprot.2011.12.042
doi: 10.1016/j.jprot.2011.12.042
Nanduri J, Semenza GL, Prabhakar NR (2017) Epigenetic changes by DNA methylation in chronic and intermittent hypoxia. Am J Physiol Lung Cell Mol Physiol 313:L1096–L1100. https://doi.org/10.1152/ajplung.00325.2017
doi: 10.1152/ajplung.00325.2017
pubmed: 28839104
pmcid: 5814703
Neckár J, Borchert G, Hlousková P et al (2013) Brief daily episode of normoxia inhibits cardioprotection conferred by chronic continuous hypoxia. Role of oxidative stress and BK
doi: 10.2174/138161281939131127115154
pubmed: 23590154
Osborn TM, Verdrengh M, Stossel TP et al (2008) Decreased levels of the gelsolin plasma isoform in patients with rheumatoid arthritis. Arthritis Res Ther 10:R117–R117. https://doi.org/10.1186/ar2520
doi: 10.1186/ar2520
pubmed: 18822171
pmcid: 2592804
Peng M, Jia J, Qin W (2015) Plasma gelsolin and matrix metalloproteinase 3 as potential biomarkers for Alzheimer disease. Neurosci Lett 595:116–121. https://doi.org/10.1016/j.neulet.2015.04.014
doi: 10.1016/j.neulet.2015.04.014
pubmed: 25864780
Piktel E, Levental I, Durnaś B et al (2018) Plasma gelsolin: indicator of inflammation and its potential as a diagnostic tool and therapeutic target. Int J Mol Sci 19:2516. https://doi.org/10.3390/ijms19092516
doi: 10.3390/ijms19092516
pubmed: 30149613
pmcid: 6164782
Posey SC, Martelli MP, Azuma T et al (2000) Failure of gelsolin overexpression to regulate lymphocyte apoptosis. Blood 95:3483–3488. https://doi.org/10.1182/blood.v95.11.3483
doi: 10.1182/blood.v95.11.3483
pubmed: 10828033
Pugh CW (2016) Modulation of the hypoxic response. Adv Exp Med Biol. https://doi.org/10.1007/978-1-4899-7678-9_18
doi: 10.1007/978-1-4899-7678-9_18
pubmed: 27343102
pmcid: 4603285
Ribon-Demars A, Jochmans-Lemoine A, Ganouna-Cohen G et al (2021) Lung oxidative stress and transcriptional regulations induced by estradiol and intermittent hypoxia. Free Radic Biol Med 164:119–129. https://doi.org/10.1016/j.freeradbiomed.2020.12.433
doi: 10.1016/j.freeradbiomed.2020.12.433
pubmed: 33385539
Semenza GL (2011) Hypoxia-inducible factor 1: regulator of mitochondrial metabolism and mediator of ischemic preconditioning. Biochim Biophys Acta 1813:1263–1268. https://doi.org/10.1016/j.bbamcr.2010.08.006
doi: 10.1016/j.bbamcr.2010.08.006
pubmed: 20732359
Shi S-S, Yue X-J, Zhao D-Y et al (2018) Plasma gelsolin level predicts acute kidney injury after cardiopulmonary bypass in infants and young children. World J Pediatr 14:143–150. https://doi.org/10.1007/s12519-017-0116-4
doi: 10.1007/s12519-017-0116-4
pubmed: 29427164
Shimoda LA, Laurie SS (2014) HIF and pulmonary vascular responses to hypoxia. J Appl Physiol 116:867–874. https://doi.org/10.1152/japplphysiol.00643.2013
doi: 10.1152/japplphysiol.00643.2013
pubmed: 24336881
Silacci P, Mazzolai L, Gauci C et al (2004) Gelsolin superfamily proteins: key regulators of cellular functions. Cell Mol Life Sci 61:2614–2623. https://doi.org/10.1007/s00018-004-4225-6
doi: 10.1007/s00018-004-4225-6
pubmed: 15526166
Song J, Sundar K, Gangaraju R, Prchal JT (2017) Regulation of erythropoiesis after normoxic return from chronic sustained and intermittent hypoxia. J Appl Physiol 123:1671–1675. https://doi.org/10.1152/japplphysiol.00119.2017
doi: 10.1152/japplphysiol.00119.2017
pubmed: 28522758
pmcid: 6734089
Tanaka M, Müllauer L, Ogiso Y et al (1995) Gelsolin: a candidate for suppressor of human bladder cancer. Cancer Res 55:3228–3232
pubmed: 7614452
Tavabe Ghavami TS, Irani S, Mirfakhrai R et al (2020) Differential expression of scinderin and gelsolin in gastric cancer and comparison with clinical and morphological characteristics. EXCLI J 19:750–761. https://doi.org/10.17179/excli2020-1335
doi: 10.17179/excli2020-1335
pubmed: 32636728
pmcid: 7332812
Wang Y, Hai B, Ai L et al (2018) Tempol relieves lung injury in a rat model of chronic intermittent hypoxia via suppression of inflammation and oxidative stress. Iran J Basic Med Sci 21:1238–1244. https://doi.org/10.22038/ijbms.2018.31716.7714
doi: 10.22038/ijbms.2018.31716.7714
pubmed: 30627367
pmcid: 6312670
Webster KA, Discher DJ, Kaiser S et al (1999) Hypoxia-activated apoptosis of cardiac myocytes requires reoxygenation or a pH shift and is independent of p53. J Clin Invest 104:239–252. https://doi.org/10.1172/JCI5871
doi: 10.1172/JCI5871
pubmed: 10430605
pmcid: 408414
Yeh Y-L, Ting W-J, Shen C-Y et al (2016) Hypoxia augments increased HIF-1α and reduced survival protein p-Akt in gelsolin (GSN)-dependent cardiomyoblast cell apoptosis. Cell Biochem Biophys 74:221–228. https://doi.org/10.1007/s12013-016-0729-6
doi: 10.1007/s12013-016-0729-6
pubmed: 27193608
Zhang W, Carreño FR, Cunningham JT, Mifflin SW (2008) Chronic sustained and intermittent hypoxia reduce function of ATP-sensitive potassium channels in nucleus of the solitary tract. Am J Physiol Regul Integr Comp Physiol 295:R1555–R1562. https://doi.org/10.1152/ajpregu.90390.2008
doi: 10.1152/ajpregu.90390.2008
pubmed: 18784334
pmcid: 2584857
Zhang Y, Luo X, Lin J et al (2020) Gelsolin promotes cancer progression by regulating epithelial-mesenchymal transition in hepatocellular carcinoma and correlates with a poor prognosis. J Oncol 2020:1980368–1980368. https://doi.org/10.1155/2020/1980368
doi: 10.1155/2020/1980368
pubmed: 32377190
pmcid: 7199561
Zhang Q, Wen X-H, Tang S-L et al (2023) Role and therapeutic potential of gelsolin in atherosclerosis. J Mol Cell Cardiol 178:59–67. https://doi.org/10.1016/j.yjmcc.2023.03.012
doi: 10.1016/j.yjmcc.2023.03.012
pubmed: 36967105