Biocatalytic synthesis of oxa(thia)diazole aryl thioethers.
Aryl thioether
Biocatalyst
Enzyme
Laccase
Oxa(thia)diazole
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
22 Aug 2024
22 Aug 2024
Historique:
received:
17
06
2024
accepted:
14
08
2024
medline:
23
8
2024
pubmed:
23
8
2024
entrez:
22
8
2024
Statut:
epublish
Résumé
A novel approach for the synthesis of 1,3,4-oxa(thia)diazole aryl thioethers through a biocatalytic strategy has been introduced. By leveraging Myceliophthora thermophila laccase (Novozym 51003) as a catalyst, catechol undergoes oxidation to ortho-quinone, facilitating subsequent 1,4-thia-Michael addition reactions. The method offers efficiency and mild reaction conditions, demonstrating promise for sustainable synthesis pathways in organic chemistry. Using this approach, 13 new derivatives of 2,5-disubstituted-1,3,4-oxa(thia)diazole aryl thioethers, with a yield of 46-94%, were synthesized.
Identifiants
pubmed: 39174618
doi: 10.1038/s41598-024-70239-3
pii: 10.1038/s41598-024-70239-3
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
19468Informations de copyright
© 2024. The Author(s).
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