Analysis and study on biomarkers of local muscle fatigue caused by repetitive lifting task.
Biomarkers
Muscle fatigue
Musculoskeletal diseases
Journal
BMC musculoskeletal disorders
ISSN: 1471-2474
Titre abrégé: BMC Musculoskelet Disord
Pays: England
ID NLM: 100968565
Informations de publication
Date de publication:
23 Aug 2024
23 Aug 2024
Historique:
received:
06
06
2023
accepted:
15
08
2024
medline:
23
8
2024
pubmed:
23
8
2024
entrez:
22
8
2024
Statut:
epublish
Résumé
Work-related musculoskeletal disorders (WMSDs) show a rapid growth trend. It has brought a huge economic burden to the society and become a serious occupational health problem that needs to be solved urgently. This study aimed to analyze the local muscle response under continuous ergonomic load, screen sensitive fatigue-related biomarkers and provide data support for the early prevention of local muscle damage and the exploration of early warning indicators. Thirteen male college student volunteers were recruited to perform simulated repetitive manual lifting tasks in the laboratory. The lifting task was designed for 4 periods which lasted for 12 min in each, and then paused for 3 min for sampling. Local muscle fatigue is assesed by the Rating of perceived exertion (RPE) and the Joint analysis of sEMG spectrum and amplitude (JASA). Elbow venous blood was collected and 14 kinds of biomarkers were analyzed, which included Metabolic markers Ammonia (AMM), Lactic acid (LAC), Creatine kinase (CK), Lactate dehydrogenase (LDH), Cartilage oligomeric matrix protein (COMP), C-telopeptide of collagen I and II (CTX-I, CTX-II) and Calcium ion (Ca Both subjective and objective fatigue appeared at the same period. Serum AMM, LAC, CK, LDH, COMP, CTX-II, Ca Metabolic markers (serum AMM, LAC, CK, LDH, COMP, CTX-II, Ca
Sections du résumé
BACKGROUND
BACKGROUND
Work-related musculoskeletal disorders (WMSDs) show a rapid growth trend. It has brought a huge economic burden to the society and become a serious occupational health problem that needs to be solved urgently. This study aimed to analyze the local muscle response under continuous ergonomic load, screen sensitive fatigue-related biomarkers and provide data support for the early prevention of local muscle damage and the exploration of early warning indicators.
METHODS
METHODS
Thirteen male college student volunteers were recruited to perform simulated repetitive manual lifting tasks in the laboratory. The lifting task was designed for 4 periods which lasted for 12 min in each, and then paused for 3 min for sampling. Local muscle fatigue is assesed by the Rating of perceived exertion (RPE) and the Joint analysis of sEMG spectrum and amplitude (JASA). Elbow venous blood was collected and 14 kinds of biomarkers were analyzed, which included Metabolic markers Ammonia (AMM), Lactic acid (LAC), Creatine kinase (CK), Lactate dehydrogenase (LDH), Cartilage oligomeric matrix protein (COMP), C-telopeptide of collagen I and II (CTX-I, CTX-II) and Calcium ion (Ca
RESULTS
RESULTS
Both subjective and objective fatigue appeared at the same period. Serum AMM, LAC, CK, LDH, COMP, CTX-II, Ca
CONCLUSIONS
CONCLUSIONS
Metabolic markers (serum AMM, LAC, CK, LDH, COMP, CTX-II, Ca
Identifiants
pubmed: 39174942
doi: 10.1186/s12891-024-07783-6
pii: 10.1186/s12891-024-07783-6
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
660Subventions
Organisme : Key Research and Development Program of Guangzhou Science and Technology Project
ID : 202206010061
Organisme : Guangzhou Key Medical Discipline
ID : 2021-2023
Organisme : The Science and Technology Program of Guangzhou
ID : 2023A03J0502
Organisme : National Key Research and Development Program of China
ID : 2022YFC2503205
Organisme : Project of Occupational Health Risk Assessment and National Occupational Health Standard Formulation of the National Institute of Occupational Health and Poison Control
ID : 131031109000160004
Informations de copyright
© 2024. The Author(s).
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