Remineralizing effect of NSF on artificial enamel caries.
Dental Caries
/ prevention & control
Humans
Tooth Remineralization
/ methods
Sodium Fluoride
/ therapeutic use
Dental Enamel
/ drug effects
Fluorides, Topical
/ therapeutic use
Cariostatic Agents
/ therapeutic use
Surface Properties
Silver Compounds
/ pharmacology
Microscopy, Electron, Scanning
In Vitro Techniques
Hydrogen-Ion Concentration
Spectrometry, X-Ray Emission
Tooth Demineralization
/ prevention & control
Dental caries
Fluoride
Remineralization
Journal
BMC oral health
ISSN: 1472-6831
Titre abrégé: BMC Oral Health
Pays: England
ID NLM: 101088684
Informations de publication
Date de publication:
22 Aug 2024
22 Aug 2024
Historique:
received:
25
04
2024
accepted:
25
07
2024
medline:
23
8
2024
pubmed:
23
8
2024
entrez:
22
8
2024
Statut:
epublish
Résumé
Nanotechnology offers new approaches and endless opportunities for remineralizing tooth decay without being toxic or causing allergies. This study aimed to determine the effect of nanosilver fluoride (NSF) on the remineralization potential of enamel caries-like lesions compared to 5% sodium fluoride varnish in permanent teeth. Fifteen teeth (molars and premolars) were gathered, cleaned, and polished using a scaler. After sectioning the teeth mesiodistally and removing the roots, the thirty specimens were subjected to a demineralized solution to induce early enamel lesions and then assigned randomly into two equal groups. The test materials were applied, and then all the specimens were subjected to a pH cycling model for 30 days. DIAGNOdent and surface roughness were investigated, and an evaluation of the enamel Ca and P weight% for Ca/P ratio calculation was done using SEM-EDX to analyze the specimens at the end of the study. The data were analyzed using an independent t-test. The mean values for the DIAGNOdent measurements for NSF and NaF at baseline and after demineralization were not significantly different (p > 0.05). After treatment, NaF varnish showed a significantly higher mean DIAGNOdent measurement (11.8 ± 5.80) than NSF (4.7 ± 1.6). The mean surface roughness of the NaF group (1.64 ± 0.39) was much higher than NSF's mean surface roughness (1.07 ± 0.21). Specimens treated with NSF had statistically significant smoother surfaces (p < 0.001). The NSF group had a higher mean Ca/P ratio (2.9 ± 0.35) than NaF (2.2 ± 0.11). This difference was statistically significant (p = 0.012). The study reveals that nano silver fluoride is a more effective treatment than sodium fluoride varnish in enhancing teeth's clinical characteristics, particularly in terms of mineral content and surface roughness, suggesting it could be an improved strategy to prevent dental caries and maintain enamel integrity.
Identifiants
pubmed: 39174977
doi: 10.1186/s12903-024-04668-x
pii: 10.1186/s12903-024-04668-x
doi:
Substances chimiques
Sodium Fluoride
8ZYQ1474W7
Fluorides, Topical
0
Cariostatic Agents
0
Silver Compounds
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
975Informations de copyright
© 2024. The Author(s).
Références
Nozari A, Ajami S, Rafiei A, Niazi E. Impact of Nano Hydroxyapatite, Nano Silver Fluoride and Sodium Fluoride Varnish on primary Teeth Enamel remineralization: an in Vitro Study. J Clin Diagn Research: JCDR. 2017;11(9):Zc97–100.
Kazeminia M, Abdi A, Shohaimi S, Jalali R, Vaisi-Raygani A, Salari N, Mohammadi M. Dental caries in primary and permanent teeth in children’s worldwide, 1995 to 2019: a systematic review and meta-analysis. Head Face Med. 2020;16:1–21.
doi: 10.1186/s13005-020-00237-z
Wen P, Chen M, Zhong Y, Dong Q, Wong H. Global burden and inequality of dental caries, 1990 to 2019. J Dent Res. 2022;101(4):392–9.
doi: 10.1177/00220345211056247
pubmed: 34852668
Flemming J, Hannig C, Hannig M. Caries Management—the role of surface interactions in de-and remineralization-processes. J Clin Med. 2022;11(23):7044.
doi: 10.3390/jcm11237044
pubmed: 36498618
pmcid: 9737279
Malcangi G, Patano A, Morolla R, De Santis M, Piras F, Settanni V, Mancini A, Di Venere D, Inchingolo F, Inchingolo AD. Analysis of dental enamel remineralization: a systematic review of technique comparisons. Bioengineering. 2023;10(4):472.
doi: 10.3390/bioengineering10040472
pubmed: 37106659
pmcid: 10135549
Hayashi M, Momoi Y, Fujitani M, Fukushima M, Imazato S, Kitasako Y, Kubo S, Nakashima S, Nikaido T, Shimizu A, et al. Evidence-based consensus for treating incipient enamel caries in adults by non-invasive methods: recommendations by GRADE guideline. Jpn Dent Sci Rev. 2020;56(1):155–63.
doi: 10.1016/j.jdsr.2020.09.005
pubmed: 33294058
pmcid: 7701193
Grohe B, Mittler S. Advanced non-fluoride approaches to dental enamel remineralization: the next level in enamel repair management. Biomaterials Biosystems. 2021;4:100029.
doi: 10.1016/j.bbiosy.2021.100029
pubmed: 36824571
pmcid: 9934497
Munteanu A, Holban A-M, Păuna M-R, Imre M, Farcașiu A-T, Farcașiu C. Review of professionally Applied fluorides for preventing Dental Caries in Children and adolescents. Appl Sci. 2022;12(3):1054.
doi: 10.3390/app12031054
Zhang J, Sardana D, Li K, Leung K, Lo E. Topical fluoride to prevent root caries: systematic review with network meta-analysis. J Dent Res. 2020;99(5):506–13.
doi: 10.1177/0022034520906384
pubmed: 32142400
Mohabatpour F, Chen X, Papagerakis S, Papagerakis P. Novel trends, challenges and new perspectives for enamel repair and regeneration to treat dental defects. Biomaterials Sci. 2022;10(12):3062–87.
doi: 10.1039/D2BM00072E
Soares-Yoshikawa AL, Varanda T, Iwamoto AS, Kantovitz KR, Puppin‐Rontani RM, Pascon FM. Fluoride release and remineralizing potential of varnishes in early caries lesions in primary teeth. Microsc Res Tech. 2021;84(5):1012–21.
doi: 10.1002/jemt.23662
pubmed: 33278320
Deulkar PV, Rathi N, Thosar N, Deshpande MA, Bane SP. Impact of sodium fluoride and nano silver fluoride-based varnishes on remineralisation of enamel caries: an in-vitro study. F1000Research 2023, 12:643.
Vaikuntam J. Fluoride varnishes: should we be using them? Pediatr Dent. 2000;22(6):513–6.
pubmed: 11132514
Baik A, Alamoudi N, El-Housseiny A, Altuwirqi A. Fluoride varnishes for preventing Occlusal Dental caries: a review. Dentistry J 2021, 9(6).
Ong WTJ, Nyam KL. Evaluation of silver nanoparticles in cosmeceutical and potential biosafety complications. Saudi J Biol Sci. 2022;29(4):2085–94.
doi: 10.1016/j.sjbs.2022.01.035
pubmed: 35531241
pmcid: 9073040
Verma S, Chevvuri R, Sharma H. Nanotechnology in dentistry: unleashing the hidden gems. J Indian Soc Periodontology. 2018;22(3):196–200.
doi: 10.4103/jisp.jisp_35_18
Arnaud M, Junior PC, Lima MG, AV ES, Araujo JT, Gallembeck A, de França Caldas Júnior A, Rosenblatt A. Nano-silver fluoride at Higher Concentration for Caries Arrest in primary molars: a Randomized Controlled Trial. Int J Clin Pediatr Dentistry. 2021;14(2):207–11.
doi: 10.5005/jp-journals-10005-1920
Pushpalatha C, Bharkhavy K, Shakir A, Augustine D, Sowmya S, Bahammam HA, Bahammam SA, Mohammad Albar NH, Zidane B, Patil S. The anticariogenic efficacy of nano silver fluoride. Front Bioeng Biotechnol. 2022;10:931327.
doi: 10.3389/fbioe.2022.931327
pubmed: 35845391
pmcid: 9283724
Butrón Téllez Girón C, Hernández Sierra JF, DeAlba-Montero I, Urbano Peña MA, Ruiz F. Therapeutic use of silver nanoparticles in the prevention and arrest of dental caries. Bioinorganic chemistry and applications 2020, 2020.
Yin IX, Yu OY, Zhao IS, Mei ML, Li QL, Tang J, Lo ECM, Chu CH. Inhibition of dentine caries using fluoride solution with silver nanoparticles: an in vitro study. J Dent. 2020;103:103512.
doi: 10.1016/j.jdent.2020.103512
pubmed: 33157159
Teixeira JA, Silva A, Dos Santos Júnior VE, de Melo Júnior PC, Arnaud M, Lima MG, Flores MAP, Stamford TCM, Dias Pereira JR, Ribeiro Targino AG, et al. Effects of a New Nano-Silver Fluoride-containing dentifrice on demineralization of Enamel and Streptococcus mutans adhesion and acidogenicity. Int J Dent. 2018;2018:1351925.
doi: 10.1155/2018/1351925
pubmed: 29853891
pmcid: 5964412
Gao Z, Chen X, Wang C, Song J, Xu J, Liu X, Qian Y, Suo H. New strategies and mechanisms for targeting Streptococcus mutans biofilm formation to prevent dental caries: a review. Microbiol Res 2023:127526.
Zameer M, Birajdar SB, Basheer SN, Peeran SW, Peeran SA, Reddy A. Nanosilver fluoride as a caries arresting agent: a narrative. Contemp Pediatr. 2021;2(1):1–13.
Roshni R, Shetty PJ. Nano silver fluoride for arresting dental caries. J Pharm Sci Res. 2020;12(12):1448–51.
Oliveira BH, Rajendra A, Veitz-Keenan A, Niederman R. The effect of silver diamine fluoride in preventing caries in the primary dentition: a systematic review and meta-analysis. Caries Res. 2019;53(1):24–32.
doi: 10.1159/000488686
pubmed: 29874642
Rosenblatt A, Stamford T, Niederman R. Oral Health Care in Disadvantaged communities’ oral Health Care in Disadvantaged communities, 1999. J Dent Res. 2009;88(2):116–25.
doi: 10.1177/0022034508329406
pubmed: 19278981
Akyildiz M, Sönmez IS. Comparison of remineralising potential of Nano Silver Fluoride, Silver Diamine Fluoride and Sodium Fluoride Varnish on Artificial caries: an in Vitro Study. Oral Health Prev Dent. 2019;17(5):469–77.
pubmed: 31268047
El-Desouky DI, Hanno A, Elhamouly Y, Hamza SA, El-Desouky LM, Dowidar KML. Preventive potential of nano silver fluoride versus sodium fluoride varnish on enamel caries like lesions in primary teeth: in vitro study. BMC Oral Health. 2022;22(1):244.
doi: 10.1186/s12903-022-02271-6
pubmed: 35725433
pmcid: 9208095
Atteya SM, Amer HA, Saleh SM, Safwat Y. Self-assembling peptide and nano-silver fluoride in remineralizing early enamel carious lesions: randomized controlled clinical trial. BMC Oral Health. 2023;23(1):577.
doi: 10.1186/s12903-023-03269-4
pubmed: 37598194
pmcid: 10439642
Minuesa-García E, Iranzo-Cortés JE, Almerich-Torres T, Bellot-Arcís C, Montiel-Company JM, Almerich-Silla JM. Diagnostic validity in Occlusal Caries detection of ICDAS II, DIAGNOdent, radiography and a combination of the three methods: an in Vitro Study. J Clin Med 2022, 11(10).
Targino AGR, Flores MAP, dos Santos Junior VE, de Godoy Bené Bezerra F, de Luna Freire H, Galembeck A, Rosenblatt A. An innovative approach to treating dental decay in children. A new anti-caries agent. J Mater Science: Mater Med. 2014;25(8):2041–7.
Buzalaf MARHA, Magalhães AC, Rios D, Honório HM, Delbem ACB. pH-cycling models for in vitro evaluation of the efficacy of fluoridated dentifrices for caries control: strengths and limitations. J Appl Oral Sci. 2010;18(4):19.
doi: 10.1590/S1678-77572010000400002
Zaror C, Matamala-Santander A, Ferrer M, Rivera‐Mendoza F, Espinoza‐Espinoza G, Martínez‐Zapata MJ. Impact of early childhood caries on oral health‐related quality of life: a systematic review and meta‐analysis. Int J Dental Hygiene. 2022;20(1):120–35.
doi: 10.1111/idh.12494
Yu OY, Lam WY-H, Wong AW-Y, Duangthip D, Chu C-H. Nonrestorative management of dental caries. Dentistry J. 2021;9(10):121.
doi: 10.3390/dj9100121
Yan IG, Zheng FM, Gao SS, Duangthip D, Lo ECM, Chu CH. Fluoride delivered via a topical application of 38% SDF and 5% NaF. Int Dent J. 2022;72(6):773–8.
doi: 10.1016/j.identj.2022.03.004
pubmed: 35570014
pmcid: 9676431
Dhama K, Patthi B, Singla A. Topical Fluorides. A literature review. 2017.
Zhao IS, Yin IX, Mei ML, Lo ECM, Tang J, Li Q, So LY, Chu CH. Remineralising dentine caries using Sodium Fluoride with Silver nanoparticles: an in Vitro Study. Int J Nanomed. 2020;15:2829–39.
doi: 10.2147/IJN.S247550
Butrón-Téllez Girón C, Mariel-Cárdenas J, Pierdant-Pérez M, Hernández-Sierra J, Morales-Sánchez J, Ruiz F. Effectiveness of a combined silver nanoparticles/fluoride varnish in dental remineralization in children: in vivo study. Superficies Y vacío. 2017;30(2):21–4.
doi: 10.47566/2017_syv30_1-020021
Keeper JH, Kibbe LJ, Thakkar-Samtani M, Heaton LJ, Desrosiers C, Vela K, Amaechi BT, Jablonski-Momeni A, Young DA, MacLean J et al. Systematic review and meta-analysis on the effect of self-assembling peptide P(11)-4 on arrest, cavitation, and progression of initial caries lesions. Journal of the American Dental Association (1939) 2023, 154(7):580–591.e511.
Fluoride Varnishes for Dental Health. A Review of the Clinical Effectiveness, Cost-effectiveness and Guidelines [Internet]. Candian Agency for Drugs and Technologies in Health 2016 [cited 7-2024]. https://www.ncbi.nlm.nih.gov/books/NBK401516/
Khan NI, Hegazy SA, Ramadan RI. Comparison of nano-silver fluoride, nano-hydroxyapatite and sodium fluoride varnishes in prevention and arrestment of initial carious lesions: a randomized controlled clinical trial. J Stomatology. 2023;76(3):151–60.
doi: 10.5114/jos.2023.131315
Robinson C, Weatherell JA, Kirkham J. The chemistry of dental caries. Dental enamel formation to destruction. edn.: CRC; 2017. pp. 223–43.
Chabuk MM, Al-Shamma AM. Surface roughness and microhardness of enamel white spot lesions treated with different treatment methods. Heliyon. 2023;9(7):e18283.
doi: 10.1016/j.heliyon.2023.e18283
pubmed: 37539286
pmcid: 10395522
I’udzuri MJ. Comparative evaluation of enamel surface roughness after minimally invasive treatment of white spot lesions: An in vitro study/I’udzuri Md Jazam. Universiti Malaya; 2021.
Nimbeni SB, Nimbeni BS, Divakar DD. Role of Chitosan in remineralization of enamel and dentin: a systematic review. Int J Clin Pediatr Dentistry. 2021;14(4):562–8.
doi: 10.5005/jp-journals-10005-1971