Stimulation of Calcium/NOS/CK1α Signaling by Cedrol Triggers Eryptosis and Hemolysis in Red Blood Cells.
anticancer
calcium
cedrol
eryptosis
hemolysis
Journal
Yonago acta medica
ISSN: 0513-5710
Titre abrégé: Yonago Acta Med
Pays: Japan
ID NLM: 0414002
Informations de publication
Date de publication:
Aug 2024
Aug 2024
Historique:
received:
01
04
2024
accepted:
23
05
2024
medline:
23
8
2024
pubmed:
23
8
2024
entrez:
23
8
2024
Statut:
epublish
Résumé
Cedrol (CRL) is a sesquiterpene alcohol present in the essential oils of coniferous trees including RBCs from healthy donors were treated with anticancer concentrations of CRL for 24 h at 37°C with varying experimental manipulations. Hemolysis was photometrically assessed by measuring hemoglobin release whereas flow cytometry was employed to detect phosphatidylserine (PS) exposure by annexin-V-FITC, intracellular Ca Significant, concentration-responsive hemolysis was noted upon CRL exposure with concomitant K CRL stimulates hemolysis and eryptosis characterized by PS exposure, Ca
Sections du résumé
Background
UNASSIGNED
Cedrol (CRL) is a sesquiterpene alcohol present in the essential oils of coniferous trees including
Methods
UNASSIGNED
RBCs from healthy donors were treated with anticancer concentrations of CRL for 24 h at 37°C with varying experimental manipulations. Hemolysis was photometrically assessed by measuring hemoglobin release whereas flow cytometry was employed to detect phosphatidylserine (PS) exposure by annexin-V-FITC, intracellular Ca
Results
UNASSIGNED
Significant, concentration-responsive hemolysis was noted upon CRL exposure with concomitant K
Conclusion
UNASSIGNED
CRL stimulates hemolysis and eryptosis characterized by PS exposure, Ca
Identifiants
pubmed: 39176191
doi: 10.33160/yam.2024.08.002
pii: 2024.08.002
pmc: PMC11335916
doi:
Types de publication
Journal Article
Langues
eng
Pagination
191-200Informations de copyright
©2024 Tottori University Medical Press.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.