Hepatocyte-specific casein kinase 1 epsilon ablation ameliorates metabolic dysfunction-associated steatohepatitis by upregulating TRAF3 in mice.

CK1ε MASH MASLD Mice TRAF3

Journal

The American journal of pathology
ISSN: 1525-2191
Titre abrégé: Am J Pathol
Pays: United States
ID NLM: 0370502

Informations de publication

Date de publication:
21 Aug 2024
Historique:
received: 27 03 2024
revised: 09 07 2024
accepted: 02 08 2024
medline: 24 8 2024
pubmed: 24 8 2024
entrez: 23 8 2024
Statut: aheadofprint

Résumé

Casein kinase 1 epsilon (CK1ε), a member of the serine/threonine protein kinase family, is known to phosphorylate a broad range of substrates. However, its role in the development of chronic liver diseases remains elusive. This study aimed to investigate the role of CK1ε in the development and progression of metabolic dysfunction-associated steatohepatitis (MASH). Hepatocyte-specific CK1ε knockout (CK1ε

Identifiants

DOI: 10.1016/j.ajpath.2024.08.003 PMID: 39179201
pubmed: 39179201
pii: S0002-9440(24)00299-2
doi: 10.1016/j.ajpath.2024.08.003
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2024. Published by Elsevier Inc.

Auteurs

Mwense Leya (M)

Biosafety Research Institute and College of Veterinary Medicine, Jeonbuk National University, Iksan-si, Jeollabuk-do, 54596, Korea.

Hyuneui Jeong (H)

Biosafety Research Institute and College of Veterinary Medicine, Jeonbuk National University, Iksan-si, Jeollabuk-do, 54596, Korea.

Daram Yang (D)

Biosafety Research Institute and College of Veterinary Medicine, Jeonbuk National University, Iksan-si, Jeollabuk-do, 54596, Korea.

Tien Huyen Ton Nu Bao (THTN)

Biosafety Research Institute and College of Veterinary Medicine, Jeonbuk National University, Iksan-si, Jeollabuk-do, 54596, Korea.

Prakash Raj Pandeya (P)

Department of Animal and Food Sciences, University of Kentucky, Lexington, KY, 40546, USA.

Sang-Ik Oh (SI)

Biosafety Research Institute and College of Veterinary Medicine, Jeonbuk National University, Iksan-si, Jeollabuk-do, 54596, Korea.

Yoon-Seok Roh (YS)

College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju-si, Chungcheongbuk-do, 28160, Republic of Korea.

Jong-Won Kim (JW)

Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: jok148@pitt.edu.

Bumseok Kim (B)

Biosafety Research Institute and College of Veterinary Medicine, Jeonbuk National University, Iksan-si, Jeollabuk-do, 54596, Korea. Electronic address: bskims@jbnu.ac.kr.

Classifications MeSH