Unlocking influenza B: exploring molecular biology and reverse genetics for epidemic control and vaccine innovation.

Influenza B virus / genetics Reverse Genetics / methods Humans Influenza, Human / prevention & control Influenza Vaccines / genetics Genome, Viral Animals Vaccine Development Molecular Biology / methods Virulence / genetics Epidemics / prevention & control
Disease control IBV Influenza Reverse genetics Virus

Journal

Virology journal
ISSN: 1743-422X
Titre abrégé: Virol J
Pays: England
ID NLM: 101231645

Informations de publication

Date de publication:
23 Aug 2024
Historique:
received: 09 04 2024
accepted: 08 07 2024
medline: 24 8 2024
pubmed: 24 8 2024
entrez: 23 8 2024
Statut: epublish

Résumé

Influenza is a highly contagious acute viral illness that affects the respiratory system, posing a significant global public health concern. Influenza B virus (IBV) causes annual seasonal epidemics. The exploration of molecular biology and reverse genetics of IBV is pivotal for understanding its replication, pathogenesis, and evolution. Reverse genetics empowers us to purposefully alter the viral genome, engineer precise genetic modifications, and unveil the secrets of virulence and resistance mechanisms. It helps us in quickly analyzing new virus strains by viral genome manipulation and the development of innovative influenza vaccines. Reverse genetics has been employed to create mutant or reassortant influenza viruses for evaluating their virulence, pathogenicity, host range, and transmissibility. Without this technique, these tasks would be difficult or impossible, making it crucial for preparing for epidemics and protecting public health. Here, we bring together the latest information on how we can manipulate the genes of the influenza B virus using reverse genetics methods, most importantly helper virus-independent techniques.

Identifiants

DOI: 10.1186/s12985-024-02433-8 PMID: 39180083
pubmed: 39180083
doi: 10.1186/s12985-024-02433-8
pii: 10.1186/s12985-024-02433-8
doi:

Substances chimiques

Influenza Vaccines 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

196

Subventions

Organisme : The Open project of National Virus Resource Center
ID : NVRC-PY-01 and NVRC-PY-03
Organisme : The Open project of National Virus Resource Center
ID : NVRC-PY-01 and NVRC-PY-03

Informations de copyright

© 2024. The Author(s).

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Auteurs

Ghayyas Ud Din (GU)

CAS Key Laboratory of Molecular Virology & Immunology, Institutional Center for Shared Technologies and Facilities, Pathogen Discovery and Big Data Platform, Shanghai Institute of Immunity and Infection, Chinese Academy of Sciences, No. 320 Yueyang Road, Shanghai, 200031, China.
University of Chinese Academy of Sciences, Beijing, China.

Chunchen Wu (C)

Department of Laboratory Medicine, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430070, People's Republic of China.

Zahra Tariq (Z)

Sundas Molecular Analysis Center, Sundas Foundation, Gujranwala, Punjab, Pakistan.

Kinza Hasham (K)

Sundas Molecular Analysis Center, Sundas Foundation, Gujranwala, Punjab, Pakistan.

Muhammad Nabeel Amjad (MN)

CAS Key Laboratory of Molecular Virology & Immunology, Institutional Center for Shared Technologies and Facilities, Pathogen Discovery and Big Data Platform, Shanghai Institute of Immunity and Infection, Chinese Academy of Sciences, No. 320 Yueyang Road, Shanghai, 200031, China.
University of Chinese Academy of Sciences, Beijing, China.

Bei Shen (B)

CAS Key Laboratory of Molecular Virology & Immunology, Institutional Center for Shared Technologies and Facilities, Pathogen Discovery and Big Data Platform, Shanghai Institute of Immunity and Infection, Chinese Academy of Sciences, No. 320 Yueyang Road, Shanghai, 200031, China.

Lihuan Yue (L)

CAS Key Laboratory of Molecular Virology & Immunology, Institutional Center for Shared Technologies and Facilities, Pathogen Discovery and Big Data Platform, Shanghai Institute of Immunity and Infection, Chinese Academy of Sciences, No. 320 Yueyang Road, Shanghai, 200031, China.

Muhammad Asif Raza (MA)

CAS Key Laboratory of Molecular Virology & Immunology, Institutional Center for Shared Technologies and Facilities, Pathogen Discovery and Big Data Platform, Shanghai Institute of Immunity and Infection, Chinese Academy of Sciences, No. 320 Yueyang Road, Shanghai, 200031, China.
University of Chinese Academy of Sciences, Beijing, China.

Muhammad Awais Ashraf (MA)

CAS Key Laboratory of Molecular Virology & Immunology, Institutional Center for Shared Technologies and Facilities, Pathogen Discovery and Big Data Platform, Shanghai Institute of Immunity and Infection, Chinese Academy of Sciences, No. 320 Yueyang Road, Shanghai, 200031, China.
University of Chinese Academy of Sciences, Beijing, China.

Lingdie Chen (L)

CAS Key Laboratory of Molecular Virology & Immunology, Institutional Center for Shared Technologies and Facilities, Pathogen Discovery and Big Data Platform, Shanghai Institute of Immunity and Infection, Chinese Academy of Sciences, No. 320 Yueyang Road, Shanghai, 200031, China.
University of Chinese Academy of Sciences, Beijing, China.

Yihong Hu (Y)

CAS Key Laboratory of Molecular Virology & Immunology, Institutional Center for Shared Technologies and Facilities, Pathogen Discovery and Big Data Platform, Shanghai Institute of Immunity and Infection, Chinese Academy of Sciences, No. 320 Yueyang Road, Shanghai, 200031, China. yhhu@ips.ac.cn.
University of Chinese Academy of Sciences, Beijing, China. yhhu@ips.ac.cn.

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Classifications MeSH

questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN de polarité négative › Orthomyxoviridae › Influenzavirus B › Virus influenza B › Unlocking influenza B: exploring molecular...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Génétique inverse › Unlocking influenza B: exploring molecular...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Unlocking influenza B: exploring molecular...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Grippe humaine › Unlocking influenza B: exploring molecular...
questionsmedicales.fr › Mélanges complexes › Produits biologiques › Vaccins › Vaccins antiviraux › Vaccins antigrippaux › Unlocking influenza B: exploring molecular...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Génome microbien › Génome viral › Unlocking influenza B: exploring molecular...
questionsmedicales.fr › Eucaryotes › Animaux › Unlocking influenza B: exploring molecular...
questionsmedicales.fr › Techniques d'investigation › Développement de vaccin › Unlocking influenza B: exploring molecular...
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Biochimie › Biologie moléculaire › Unlocking influenza B: exploring molecular...
questionsmedicales.fr › Phénomènes microbiologiques › Virulence › Unlocking influenza B: exploring molecular...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Épidémies de maladies › Épidémies › Unlocking influenza B: exploring molecular...