Prehospital guidelines on in-water traumatic spinal injuries for lifeguards and prehospital emergency medical services: an international Delphi consensus study.

Delphi Drowning Emergency medical service (EMS) Guideline Lifeguard Spinal cord injuries Spinal fractures Spinal injuries Trauma Water

Journal

Scandinavian journal of trauma, resuscitation and emergency medicine
ISSN: 1757-7241
Titre abrégé: Scand J Trauma Resusc Emerg Med
Pays: England
ID NLM: 101477511

Informations de publication

Date de publication:
23 Aug 2024
Historique:
received: 05 03 2024
accepted: 16 08 2024
medline: 24 8 2024
pubmed: 24 8 2024
entrez: 23 8 2024
Statut: epublish

Résumé

Trauma guidelines on spinal motion restriction (SMR) have changed drastically in recent years. An international group of experts explored whether consensus could be reached and if guidelines on SMR performed by trained lifeguards and prehospital EMS following in-water traumatic spinal cord injury (TSCI) should also be changed. An international three-round Delphi process was conducted from October 2022 to November 2023. In Delphi round one, brainstorming resulted in an exhaustive list of recommendations for handling patients with suspected in-water TSCI. The list was also used to construct a preliminary flowchart for in-water SMR. In Delphi round two, three levels of agreement for each recommendation and the flowchart were established. Recommendations with strong consensus (≥ 85% agreement) underwent minor revisions and entered round three; recommendations with moderate consensus (75-85% agreement) underwent major revisions in two consecutive phases; and recommendations with weak consensus (< 75% agreement) were excluded. In Delphi round 3, the level of consensus for each of the final recommendations and each of the routes in the flowchart was tested using the same procedure as in Delphi round 2. Twenty-four experts participated in Delphi round one. The response rates for Delphi rounds two and three were 92% and 88%, respectively. The study resulted in 25 recommendations and one flowchart with four flowchart paths; 24 recommendations received strong consensus (≥ 85%), and one recommendation received moderate consensus (81%). Each of the four paths in the flowchart received strong consensus (90-95%). The integral flowchart received strong consensus (93%). This study produced expert consensus on 25 recommendations and a flowchart on handling patients with suspected in-water TSCI by trained lifeguards and prehospital EMS. These results provide clear and simple guidelines on SMR, which can standardise training and guidelines on SMR performed by trained lifeguards or prehospital EMS.

Sections du résumé

BACKGROUND BACKGROUND
Trauma guidelines on spinal motion restriction (SMR) have changed drastically in recent years. An international group of experts explored whether consensus could be reached and if guidelines on SMR performed by trained lifeguards and prehospital EMS following in-water traumatic spinal cord injury (TSCI) should also be changed.
METHODS METHODS
An international three-round Delphi process was conducted from October 2022 to November 2023. In Delphi round one, brainstorming resulted in an exhaustive list of recommendations for handling patients with suspected in-water TSCI. The list was also used to construct a preliminary flowchart for in-water SMR. In Delphi round two, three levels of agreement for each recommendation and the flowchart were established. Recommendations with strong consensus (≥ 85% agreement) underwent minor revisions and entered round three; recommendations with moderate consensus (75-85% agreement) underwent major revisions in two consecutive phases; and recommendations with weak consensus (< 75% agreement) were excluded. In Delphi round 3, the level of consensus for each of the final recommendations and each of the routes in the flowchart was tested using the same procedure as in Delphi round 2.
RESULTS RESULTS
Twenty-four experts participated in Delphi round one. The response rates for Delphi rounds two and three were 92% and 88%, respectively. The study resulted in 25 recommendations and one flowchart with four flowchart paths; 24 recommendations received strong consensus (≥ 85%), and one recommendation received moderate consensus (81%). Each of the four paths in the flowchart received strong consensus (90-95%). The integral flowchart received strong consensus (93%).
CONCLUSIONS CONCLUSIONS
This study produced expert consensus on 25 recommendations and a flowchart on handling patients with suspected in-water TSCI by trained lifeguards and prehospital EMS. These results provide clear and simple guidelines on SMR, which can standardise training and guidelines on SMR performed by trained lifeguards or prehospital EMS.

Identifiants

pubmed: 39180135
doi: 10.1186/s13049-024-01249-3
pii: 10.1186/s13049-024-01249-3
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

76

Informations de copyright

© 2024. The Author(s).

Références

Ahuja CS, Wilson JR, Nori S, et al. Traumatic spinal cord injury. Nat Rev Dis Primers. 2017;3(1):17018. https://doi.org/10.1038/nrdp.2017.18 .
doi: 10.1038/nrdp.2017.18 pubmed: 28447605
Chang SKY, Tominaga GT, Wong JH, Weldon EJ, Kaan KT. Risk factors for water sports-related cervical spine injuries. J Trauma Injury Infect Crit Care. 2006;60(5):1041–6. https://doi.org/10.1097/01.ta.0000218256.39295.8f .
doi: 10.1097/01.ta.0000218256.39295.8f
Torg JS. Epidemiology, pathomechanics, and prevention of athletic injuries to the cervical spine. Med Sci Sports Exerc. 1985;17(3):295–303.
doi: 10.1249/00005768-198506000-00001 pubmed: 3894866
Oyinbo CA. Secondary injury mechanisms in traumatic spinal cord injury: a nugget of this multiply cascade. Acta Neurobiol Exp (Wars). 2011;71(2):281–99.
doi: 10.55782/ane-2011-1848 pubmed: 21731081
Ray SK, Dixon CE, Banik NL. Molecular mechanisms in the pathogenesis of traumatic brain injury. Histol Histopathol. 2002;17(4):1137–52. https://doi.org/10.14670/HH-17.1137 .
doi: 10.14670/HH-17.1137 pubmed: 12371142
Rossignol S, Schwab M, Schwartz M, Fehlings MG. Spinal cord injury: time to move? J Neurosci. 2007;27(44):11782–92. https://doi.org/10.1523/JNEUROSCI.3444-07.2007 .
doi: 10.1523/JNEUROSCI.3444-07.2007 pubmed: 17978014 pmcid: 6673354
Tator CH, Fehlings MG. Review of the secondary injury theory of acute spinal cord trauma with emphasis on vascular mechanisms. J Neurosurg. 1991;75(1):15–26. https://doi.org/10.3171/jns.1991.75.1.0015 .
doi: 10.3171/jns.1991.75.1.0015 pubmed: 2045903
Choo AM, Liu J, Lam CK, Dvorak M, Tetzlaff W, Oxland TR. Contusion, dislocation, and distraction: primary hemorrhage and membrane permeability in distinct mechanisms of spinal cord injury. SPI. 2007;6(3):255–66. https://doi.org/10.3171/spi.2007.6.3.255 .
doi: 10.3171/spi.2007.6.3.255
Maschmann C, Jeppesen E, Rubin MA, Barfod C. New clinical guidelines on the spinal stabilisation of adult trauma patients - consensus and evidence based. Scand J Trauma Resusc Emerg Med. 2019;27(1):77. https://doi.org/10.1186/s13049-019-0655-x .
doi: 10.1186/s13049-019-0655-x pubmed: 31426850 pmcid: 6700785
Kornhall DK. The Norwegian guidelines for the prehospital management of adult trauma patients with potential spinal injury. Scand J Trauma Resusc Emerg Med 2017.
Yli-Hankala A, Chew MS, Olkkola KT, Rehn M, Sverrisson KÖ, Møller MH. Clinical practice guideline on spinal stabilisation of adult trauma patients: Endorsement by the Scandinavian Society of Anaesthesiology and Intensive Care Medicine. Acta Anaesthesiol Scand. 2021;65(7):986–7. https://doi.org/10.1111/aas.13933 .
doi: 10.1111/aas.13933 pubmed: 34048025
Amorim EC, Vetter H, Mascarenhas LB, Gomes EG, Carvalho JBF, Gomes JF. Spine trauma due to diving: main features and short-term neurological outcome. Spinal Cord. 2011;49(2):206–10. https://doi.org/10.1038/sc.2010.79 .
doi: 10.1038/sc.2010.79 pubmed: 20625383
Bailes JE, Herman JM, Quigley MR, Cerullo LJ, Meyer PR. Diving injuries of the cervical spine. Surg Neurol. 1990;34(3):155–8. https://doi.org/10.1016/0090-3019(90)90064-V .
doi: 10.1016/0090-3019(90)90064-V pubmed: 2385821
Bárbara-Bataller E, Méndez-Suárez JL, Alemán-Sánchez C, Sánchez-Enríquez J, Sosa-Henríquez M. Lesión medular secundaria a zambullida en Canarias. Neurocirugía. 2017;28(4):183–9. https://doi.org/10.1016/j.neucir.2017.01.005 .
doi: 10.1016/j.neucir.2017.01.005 pubmed: 28343903
Chan-Seng E, Perrin FE, Segnarbieux F, Lonjon N. Cervical spine injuries from diving accident: a 10-year retrospective descriptive study on 64 patients. Orthop Traumatol Surg Res. 2013;99(5):607–13. https://doi.org/10.1016/j.otsr.2013.04.003 .
doi: 10.1016/j.otsr.2013.04.003 pubmed: 23911134
Frankel HL, Montero FA, Penny PT. Spinal cord injuries due to diving. Spinal Cord. 1980;18(2):118–22. https://doi.org/10.1038/sc.1980.19 .
doi: 10.1038/sc.1980.19
Griffiths ER. Spinal injuries from swimming and diving treated in the spinal department of Royal Perth Rehabilitation Hospital: 1956–1978. Spinal Cord. 1980;18(2):109–17. https://doi.org/10.1038/sc.1980.18 .
doi: 10.1038/sc.1980.18
Kiwerski J. Cervical spine injuries caused by diving into water. Spinal Cord. 1980;18(2):101–5. https://doi.org/10.1038/sc.1980.16 .
doi: 10.1038/sc.1980.16
Green BA, Gabrielsen MA, Hall WJ, O’Heir J. Analysis of swimming pool accidents resulting in spinal cord injury. Spinal Cord. 1980;18(2):94–100. https://doi.org/10.1038/sc.1980.15 .
doi: 10.1038/sc.1980.15
DeVivo MJ, Sekar P. Prevention of spinal cord injuries that occur in swimming pools. Spinal Cord. 1997;35(8):509–15. https://doi.org/10.1038/sj.sc.3100430 .
doi: 10.1038/sj.sc.3100430 pubmed: 9267915
Korres DS, Benetos IS, Themistocleous GS, Mavrogenis AF, Nikolakakos L, Liantis PT. Diving injuries of the cervical spine in amateur divers. Spine J. 2006;6(1):44–9. https://doi.org/10.1016/j.spinee.2005.06.013 .
doi: 10.1016/j.spinee.2005.06.013 pubmed: 16413447
Breindahl N, Wolthers SA, Møller TP, et al. Characteristics and critical care interventions in drowning patients treated by the Danish Air Ambulance from 2016 to 2021: a nationwide registry-based study with 30-day follow-up. Scand J Trauma Resusc Emerg Med. 2024;32(1):17. https://doi.org/10.1186/s13049-024-01189-y .
doi: 10.1186/s13049-024-01189-y pubmed: 38448994 pmcid: 10916225
Murphy MK, Black NA, Lamping DL, et al. Consensus development methods, and their use in clinical guideline development. Health Technol Assess. 1998;2(3):i-iv, 1–88.
Gattrell WT, Logullo P, van Zuuren EJ, et al. ACCORD (ACcurate COnsensus Reporting Document): A reporting guideline for consensus methods in biomedicine developed via a modified Delphi. PLoS Med. 2024;21(1): e1004326. https://doi.org/10.1371/journal.pmed.1004326 .
doi: 10.1371/journal.pmed.1004326 pubmed: 38261576 pmcid: 10805282
Akins RB, Tolson H, Cole BR. Stability of response characteristics of a Delphi panel: application of bootstrap data expansion. BMC Med Res Methodol. 2005;5(1):37. https://doi.org/10.1186/1471-2288-5-37 .
doi: 10.1186/1471-2288-5-37 pubmed: 16321161 pmcid: 1318466
Harris PA, Taylor R, Thielke R, Payne J, Gonzalez N, Conde JG. Research electronic data capture (REDCap)—A metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform. 2009;42(2):377–81. https://doi.org/10.1016/j.jbi.2008.08.010 .
doi: 10.1016/j.jbi.2008.08.010 pubmed: 18929686
Szpilman D, Palacios Aguilar J, Barcala-Furelos R, et al. Drowning and aquatic injuries dictionary. Resusc Plus. 2021;5: 100072. https://doi.org/10.1016/j.resplu.2020.100072 .
doi: 10.1016/j.resplu.2020.100072 pubmed: 34223340 pmcid: 8244532
Diamond IR, Grant RC, Feldman BM, et al. Defining consensus: a systematic review recommends methodologic criteria for reporting of Delphi studies. J Clin Epidemiol. 2014;67(4):401–9. https://doi.org/10.1016/j.jclinepi.2013.12.002 .
doi: 10.1016/j.jclinepi.2013.12.002 pubmed: 24581294
R Core Team. R: A language and environment for statistical computing. Published 2022. https://www.R-project.org/
Watson RS, Cummings P. Cervical spine injuries among submersion victims. J Trauma. 2001;51:658–62.
doi: 10.1097/00005373-200110000-00006 pubmed: 11586155
Australian Resuscitation Council, New Zealand Resuscitation Council. ANZCOR Guideline 9.1.6: Management of Suspected Spinal Injury. Published online January 2016. Accessed January 2, 2023. https://www.resus.org.nz/assets/Uploads/ANZCOR-Guideline-9-1-6-Spinal-Jan16.pdf
Zideman DA, Singletary EM, Borra V, et al. European resuscitation council guidelines 2021: first aid. Resuscitation. 2021;161:270–90. https://doi.org/10.1016/j.resuscitation.2021.02.013 .
doi: 10.1016/j.resuscitation.2021.02.013 pubmed: 33773828
Romanelli D, Farrell MW. AVPU (Alert, Voice, Pain, Unresponsive). In: StatPearls. StatPearls Publishing; 2020. Accessed June 19, 2020. http://www.ncbi.nlm.nih.gov/books/NBK538431/
Benger J, Blackham J. Why do we put cervical collars on conscious trauma patients? Scand J Trauma Resusc Emerg Med. 2009;17(1):44. https://doi.org/10.1186/1757-7241-17-44 .
doi: 10.1186/1757-7241-17-44 pubmed: 19765308 pmcid: 2751736
Hood N, Considine J. Spinal immobilisaton in pre-hospital and emergency care: A systematic review of the literature. Australas Emerg Nurs J. 2015;18(3):118–37. https://doi.org/10.1016/j.aenj.2015.03.003 .
doi: 10.1016/j.aenj.2015.03.003 pubmed: 26051883
Purvis TA, Carlin B, Driscoll P. The definite risks and questionable benefits of liberal pre-hospital spinal immobilisation. Am J Emerg Med. 2017;35(6):860–6. https://doi.org/10.1016/j.ajem.2017.01.045 .
doi: 10.1016/j.ajem.2017.01.045 pubmed: 28169039
Barati KAM. The effect of soft and rigid cervical collars on head and neck immobilization in healthy subjects. Asian Spine J. 2017;11:390–5.
doi: 10.4184/asj.2017.11.3.390 pubmed: 28670406 pmcid: 5481593
Ivancic PC. Do cervical collars and cervicothoracic orthoses effectively stabilize the injured cervical spine? A biomechanical investigation. Spine. 2013;38(13):E767–74. https://doi.org/10.1097/BRS.0b013e318290fb0f .
doi: 10.1097/BRS.0b013e318290fb0f pubmed: 23486409
Horodyski M, DiPaola CP, Conrad BP, Rechtine GR. Cervical collars are insufficient for immobilizing an unstable cervical spine injury. J Emerg Med. 2011;41(5):513–9. https://doi.org/10.1016/j.jemermed.2011.02.001 .
doi: 10.1016/j.jemermed.2011.02.001 pubmed: 21397431
Connor D, Greaves I, Porter K, Bloch M, On behalf of the consensus group, Faculty of Pre-Hospital Care. Pre-hospital spinal immobilisation: an initial consensus statement. Emerg Med J. 2013;30(12):1067–1069. https://doi.org/10.1136/emermed-2013-203207
Holla MHG. Restriction of cervical intervertebral movement with different types of external immobilizers a cadaveric 3D analysis study. Spine (Phila Pa 1976). 2017;42:E1182–9.
doi: 10.1097/BRS.0000000000002107 pubmed: 28230622
Podolsky SBL. Efficacy of cervical spine immobilization methods. J Trauma. 1983;23:461–5.
doi: 10.1097/00005373-198306000-00003 pubmed: 6864837
McCabe JB, Nolan DJ. Comparison of the effectiveness of different cervical immobilization collars. Ann Emerg Med. 1986;15:50–3.
doi: 10.1016/S0196-0644(86)80487-5 pubmed: 3942357
Pryce RMN. Prehospital spinal immobilization: effect of effort on kinematics of voluntary head-neck motion assessed using accelerometry. Prehosp Disaster Med. 2016;31:36–42.
doi: 10.1017/S1049023X1500552X pubmed: 26674843
Davies G, Deakin C. The effect of a rigid collar on intracranial pressure. Injury. 1996;27:647–9.
doi: 10.1016/S0020-1383(96)00115-5 pubmed: 9039362
Maissan IM, Ketelaars R, Vlottes B, Hoeks SE, den Hartog D, Stolker RJ. Increase in intracranial pressure by application of a rigid cervical collar: a pilot study in healthy volunteers. Eur J Emerg Med. 2018;25(6):e24–8. https://doi.org/10.1097/MEJ.0000000000000490 .
doi: 10.1097/MEJ.0000000000000490 pubmed: 28727580
Patel MB, Humble SS, Cullinane DC, et al. Cervical spine collar clearance in the obtunded adult blunt trauma patient: a systematic review and practice management guideline from the Eastern Association for the Surgery of Trauma. J Trauma Acute Care Surg. 2015;78(2):430–41. https://doi.org/10.1097/TA.0000000000000503 .
doi: 10.1097/TA.0000000000000503 pubmed: 25757133 pmcid: 4409130
Freauf M, Puckeridge N. To board or not to board: an evidence review of prehospital spinal immobilization. JEMS. 2015;40(11):43–5.
pubmed: 26721114
Lerner EB, Billittier AJ, Moscati RM. The effects of neutral positioning with and without padding on spinal immobilization of healthy subjects. Prehosp Emerg Care. 1998;2(2):112–6. https://doi.org/10.1080/10903129808958853 .
doi: 10.1080/10903129808958853 pubmed: 9709329
Ham WHW, Schoonhoven L, Schuurmans MJ, Leenen LPH. Pressure ulcers, indentation marks and pain from cervical spine immobilization with extrication collars and headblocks: an observational study. Injury. 2016;47(9):1924–31. https://doi.org/10.1016/j.injury.2016.03.032 .
doi: 10.1016/j.injury.2016.03.032 pubmed: 27158006
Rogers L. No place for the rigid cervical collar in pre-hospital care. International Paramedic Practice. 2017;7(1):12–5. https://doi.org/10.12968/ippr.2017.7.1.12 .
doi: 10.12968/ippr.2017.7.1.12
International Life Saving Federation Medical Committee. Medical Position Statement 21: Spinal Injury Management. Published online 2016.
Martin MJ, Bush L. Cervical spine evaluation and clearance in the intoxicated patient: a prospective Western trauma association multi-institutional trial and survey accreditation statement. J Trauma Acute Care Surg. 2017;83:1032–40.
doi: 10.1097/TA.0000000000001650 pubmed: 28723840
Konstantinidis A, Plurad D. The presence of nonthoracic distracting injuries does not affect the initial clinical examination of the cervical spine in evaluable blunt trauma patients: a prospective observational study. J Trauma Inj Infect Crit Care. 2011;71:528–32.
Dahlquist RT, Fischer PE, Desai H, et al. Femur fractures should not be considered distracting injuries for cervical spine assessment. Am J Emerg Med. 2015;33(12):1750–4. https://doi.org/10.1016/j.ajem.2015.08.009 .
doi: 10.1016/j.ajem.2015.08.009 pubmed: 26346048
Cason BRJ. Thoracolumbar spine clearance: clinical examination for patients with distracting injuries. J Trauma Acute Care Surg. 2016;80:125–30.
doi: 10.1097/TA.0000000000000884 pubmed: 26491795
National Association of Emergency Medical Technicians (U.S.), Pre-Hospital Trauma Life Support Committee, American College of Surgeons, Committee on Trauma. Spinal Trauma. In: Emerton C, Editor. PHTLS® Prehospital Trauma Life Support. 8th ed. Burlington, MA: Jones & Bartlett Learning; 2016:289–314.
Nypaver M, Treloar D. Neutral cervical spine positioning in children. Ann Emerg Med. 1994;23(2):208–11. https://doi.org/10.1016/S0196-0644(94)70032-X .
doi: 10.1016/S0196-0644(94)70032-X pubmed: 8304600
Stroh G, Braude D. Can an out-of-hospital cervical spine clearance protocol identify all patients with injuries? An argument for selective immobilization. Ann Emerg Med. 2001;37(6):609–15. https://doi.org/10.1067/mem.2001.114409 .
doi: 10.1067/mem.2001.114409 pubmed: 11385329
Burton JH, Dunn MG, Harmon NR, Hermanson TA, Bradshaw JR. A Statewide, prehospital emergency medical service selective patient spine immobilization protocol. J Trauma Injury Infect Crit Care. 2006;61(1):161–7. https://doi.org/10.1097/01.ta.0000224214.72945.c4 .
doi: 10.1097/01.ta.0000224214.72945.c4
Domeier RM. Indications for prehospital spinal immobilization. Prehosp Emerg Care. 1999;3(3):251–3. https://doi.org/10.1080/10903129908958946 .
doi: 10.1080/10903129908958946 pubmed: 10424865
Stiell IG. The Canadian C-spine rule for radiography in alert and stable trauma patients. JAMA. 2001;286(15):1841. https://doi.org/10.1001/jama.286.15.1841 .
doi: 10.1001/jama.286.15.1841 pubmed: 11597285
Hoffman JR, Mower WR, Wolfson AB, Todd KH, Zucker MI. Validity of a set of clinical criteria to rule out injury to the cervical spine in patients with blunt trauma. N Engl J Med. 2000;343(2):94–9. https://doi.org/10.1056/NEJM200007133430203 .
doi: 10.1056/NEJM200007133430203 pubmed: 10891516
Michaleff ZA, Maher CG, Verhagen AP, Rebbeck T, Lin CWC. Accuracy of the Canadian C-spine rule and NEXUS to screen for clinically important cervical spine injury in patients following blunt trauma: a systematic review. CMAJ. 2012;184(16):E867–76. https://doi.org/10.1503/cmaj.120675 .
doi: 10.1503/cmaj.120675 pubmed: 23048086 pmcid: 3494329
Mahajan V, Linstone HA, Turoff M. The Delphi method: techniques and applications. J Mark Res. 1976;13(3):317. https://doi.org/10.2307/3150755 .
doi: 10.2307/3150755

Auteurs

Niklas Breindahl (N)

Prehospital Center Region Zealand, Ringstedgade 61, 13, 4700, Næstved, Denmark. niklas.breindahl@gmail.com.
Department of Neonatal and Pediatric Intensive Care, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark. niklas.breindahl@gmail.com.
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. niklas.breindahl@gmail.com.
International Life Saving Federation, Leuven, Belgium. niklas.breindahl@gmail.com.
International Drowning Researchers' Alliance, Kuna, ID, USA. niklas.breindahl@gmail.com.

Joost L M Bierens (JLM)

International Life Saving Federation, Leuven, Belgium.
International Drowning Researchers' Alliance, Kuna, ID, USA.
Extreme Environments Laboratory, School of Sport, Health and Exercise Science, University of Portsmouth, Portsmouth, UK.

Sebastian Wiberg (S)

Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
Department of Cardiothoracic Anaesthesiology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.

Roberto Barcala-Furelos (R)

International Life Saving Federation, Leuven, Belgium.
International Drowning Researchers' Alliance, Kuna, ID, USA.
REMOSS Research Group, Faculty of Education and Sports Sciences, Universidade de Vigo, Pontevedra, Spain.

Christian Maschmann (C)

Department of Emergency Medicine NFZ, Cantonal Hospital St. Gallen, Gallen, Switzerland.

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