Video capsule endoscopy findings in dogs with chronic enteropathy and in healthy dogs.
ALICAM
canine
gastrointestinal disease
small intestine
Journal
Journal of veterinary internal medicine
ISSN: 1939-1676
Titre abrégé: J Vet Intern Med
Pays: United States
ID NLM: 8708660
Informations de publication
Date de publication:
24 Aug 2024
24 Aug 2024
Historique:
received:
01
03
2024
accepted:
31
07
2024
medline:
24
8
2024
pubmed:
24
8
2024
entrez:
24
8
2024
Statut:
aheadofprint
Résumé
Video capsule endoscopy is a noninvasive technique for evaluation of the gastrointestinal tract. To investigate the safety of using the video capsule ALICAM in dogs with chronic enteropathy (CE) >10 kg, and to compare macroscopic gastrointestinal morphology between CE dogs and healthy controls (HC). Fifteen CE dogs and 15 similarly breed, age and body weight matched HC. All dogs underwent a clinical work up including blood analyses, fecal samples, abdominal ultrasonographic examination, and blood pressure measurement. The dogs were withheld from food for 16 hours before and 8 hours after they PO received an ALICAM. All recordings were quality assessed, and blindly evaluated by 2 trained observers. The median age of CE dogs and HC was 3.3 (interquartile range [IQR] 2.5-5.9) years and 4.7 (IQR 3.3-5.6) years, respectively. The median body weight in the CE dogs and HC was 25.9 (IQR 20.6-30.9) kg, and 29 (IQR 16.2-30.5) kg, respectively. Complete recordings of the gastrointestinal tract were obtained from all dogs without complications. No significant differences were found between groups regarding number of abnormalities such as irregular mucosa, erythema, nonbleeding erosions, bleeding erosions, and dilated lacteals, as well as severity and extent of the abnormalities. The use of ALICAM for evaluation of the gastrointestinal tract in CE dogs and HC seems safe and feasible regarding gastrointestinal transit and macroscopic morphology assessment in dogs >10 kg. Abnormalities were found in similar proportions in CE dogs and HC.
Sections du résumé
BACKGROUND
BACKGROUND
Video capsule endoscopy is a noninvasive technique for evaluation of the gastrointestinal tract.
OBJECTIVE
OBJECTIVE
To investigate the safety of using the video capsule ALICAM in dogs with chronic enteropathy (CE) >10 kg, and to compare macroscopic gastrointestinal morphology between CE dogs and healthy controls (HC).
ANIMALS
METHODS
Fifteen CE dogs and 15 similarly breed, age and body weight matched HC.
METHODS
METHODS
All dogs underwent a clinical work up including blood analyses, fecal samples, abdominal ultrasonographic examination, and blood pressure measurement. The dogs were withheld from food for 16 hours before and 8 hours after they PO received an ALICAM. All recordings were quality assessed, and blindly evaluated by 2 trained observers.
RESULTS
RESULTS
The median age of CE dogs and HC was 3.3 (interquartile range [IQR] 2.5-5.9) years and 4.7 (IQR 3.3-5.6) years, respectively. The median body weight in the CE dogs and HC was 25.9 (IQR 20.6-30.9) kg, and 29 (IQR 16.2-30.5) kg, respectively. Complete recordings of the gastrointestinal tract were obtained from all dogs without complications. No significant differences were found between groups regarding number of abnormalities such as irregular mucosa, erythema, nonbleeding erosions, bleeding erosions, and dilated lacteals, as well as severity and extent of the abnormalities.
CONCLUSIONS AND CLINICAL IMPORTANCE
CONCLUSIONS
The use of ALICAM for evaluation of the gastrointestinal tract in CE dogs and HC seems safe and feasible regarding gastrointestinal transit and macroscopic morphology assessment in dogs >10 kg. Abnormalities were found in similar proportions in CE dogs and HC.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Skogsborg's Research Foundation
ID : 25173801
Organisme : Carenet
ID : 2020.4.1-4652
Organisme : Sveland's Research Foundation
ID : 25172801
Organisme : Thure F och Karin Forsbergs Stiftelse
ID : 2020-01
Informations de copyright
© 2024 The Author(s). Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC on behalf of American College of Veterinary Internal Medicine.
Références
Dandrieux JRS, Mansfield CS. Chronic enteropathy in canines: prevalence, impact and management strategies. Vet Med (Auckl). 2019;10:203‐214.
Dandrieux JR. Inflammatory bowel disease versus chronic enteropathy in dogs: are they one and the same? J Small Anim Pract. 2016;57:589‐599.
Berghoff N, Steiner JM. Laboratory tests for the diagnosis and management of chronic canine and feline enteropathies. Vet Clin North Am Small Anim Pract. 2011;41:311‐328.
Simpson KW, Jergens AE. Pitfalls and progress in the diagnosis and management of canine inflammatory bowel disease. Vet Clin North Am Small Anim Pract. 2011;41:381‐398.
Makielski K, Cullen J, O'Connor A, Jergens AE. Narrative review of therapies for chronic enteropathies in dogs and cats. J Vet Intern Med. 2019;33:11‐22.
Jergens AE, Heilmann RM. Canine chronic enteropathy—current state‐of‐the‐art and emerging concepts. Front Vet Sci. 2022;9:1‐25.
Washabau RJ, Day MJ, Willard MD, et al. Endoscopic, biopsy, and histopathologic guidelines for the evaluation of gastrointestinal inflammation in companion animals. J Vet Intern Med. 2010;24:10‐26.
Iddan G, Meron G, Glukhovsky A, Swain P. Wireless capsule endoscopy. Nature. 2000;405:417.
Mergener K, Ponchon T, Gralnek I, et al. Literature review and recommendations for clinical application of small‐bowel capsule endoscopy, based on a panel discussion by international experts. Consensus statements for small‐bowel capsule endoscopy, 2006/2007. Endoscopy. 2007;39:895‐909.
Höög CM, Bark LÅ, Arkani J, Gorsetman J, Broström O, Sjöqvist U. Capsule retentions and incomplete capsule endoscopy examinations: an analysis of 2300 examinations. Gastroent Res Pract. 2012;2012:1‐7.
Lee AC, Epe C, Simpson KW, et al. Utility of capsule endoscopy for evaluating anthelmintic efficacy in fully conscious dogs. Int J Parasitol. 2011;41:1377‐1383.
Lee AC, Hostetler JA, Bowman DD. Assessing the speed of kill of hookworms, Ancylostoma caninum, by Advantage Multi (R) for Dogs using endoscopic methods. Vet Parasitol. 2014;204:402‐406.
Lee AC, Epe C, Bowman DD. Determination of anthelmintic efficacy against Toxocara canis in dogs by use of capsule endoscopy. Vet Parasitol. 2015;212:227‐231.
Davignon DL, Lee AC, Johnston AN, et al. Evaluation of capsule endoscopy to detect mucosal lesions associated with gastrointestinal bleeding in dogs. J Small Anim Pract. 2016;57:148‐158.
Mabry K, Hill T, Marks SL, Hardy BT. Use of video capsule endoscopy to identify gastrointestinal lesions in dogs with microcytosis or gastrointestinal hemorrhage. J Vet Intern Med. 2019;33:1964‐1969.
Hardy BT, Gentile‐Solomon J, Solomon JA. Multiple gastric erosions diagnosed by means of capsule endoscopy in a dog. J Am Vet Med Assoc. 2016;249:926‐930.
Stiller J, Defarges AM, Brisson BA, Bersenas AME, Pearl DL. Feasibility, complications, and quality of visualization using video capsule endoscopy in 40 dogs with overt or questionable gastrointestinal bleeding. J Vet Intern Med. 2021;35:1743‐1753.
Defarges A, Stiller J, Solomon JA. Gastrointestinal angiodysplasias diagnosed using video capsule endoscopy in 15 dogs. J Vet Intern Med. 2023;37:428‐436.
Allenspach K, Wieland B, Grone A, et al. Chronic enteropathies in dogs: evaluation of risk factors for negative outcome. J Vet Intern Med. 2007;21:700‐708.
Gold AJ, Langlois DK, Refsal KR. Evaluation of basal serum or plasma cortisol concentrations for the diagnosis of hypoadrenocorticism in dogs. J Vet Intern Med. 2016;30:1798‐1805.
Acierno MJ, Brown S, Coleman AE, et al. ACVIM consensus statement: guidelines for the identification, evaluation, and management of systemic hypertension in dogs and cats. J Vet Intern Med. 2018;32:1803‐1822.
Park SC, Keum B, Hyun JJ, et al. A novel cleansing score system for capsule endoscopy. World J Gastroenterol. 2010;16:875‐880.
Rosa B, Margalit‐Yehuda R, Gatt K, et al. Scoring systems in clinical small‐bowel capsule endoscopy: all you need to know! Endosc Int Open. 2021;09:E802‐E823.
Bourreille A, Ignjatovic A, Aabakken L, et al. Role of small‐bowel endoscopy in the management of patients with inflammatory bowel disease: an international OMED‐ECCO consensus. Endoscopy. 2009;41:618‐637.
Sidhu R, Brunt LK, Morley SR, Sanders DS, McAlindon ME. Undisclosed use of nonsteroidal anti‐inflammatory drugs may underlie small‐bowel injury observed by capsule endoscopy. Clin Gastroenterol Hepatol. 2010;8:992‐995.
Bar‐Meir S. Review article: capsule endoscopy—are all small intestinal lesions Crohn's disease? Aliment Pharm Therap. 2006;24:19‐21.
Haghighi D, Zuccaro G, Vargo J, et al. Comparison of capsule endoscopy (CE) findings of healthy subjects (HS) to an obscure gastrointestinal bleeding (OGIB) patient population. Gastrointest Endosc. 2005;61:Ab104.
Goldstein JL, Eisen GM, Lewis B, et al. Video capsule endoscopy to prospectively assess small bowel injury with celecoxib, naproxen plus omeprazole, and placebo. Clin Gastroenterol Hepatol. 2005;3:133‐141.
Graham DY, Opekun AR, Willingham FF, Qureshi WA. Visible small‐intestinal mucosal injury in chronic NSAID users. Clin Gastroenterol Hepatol. 2005;3:55‐59.
Jablonski SA. Pathophysiology, diagnosis, and management of canine intestinal lymphangiectasia: a comparative review. Animals (Basel). 2022;12:1‐20.
Littman MP, Dambach DM, Vaden SL, Giger U. Familial protein‐losing enteropathy and protein‐losing nephropathy in soft coated wheaten terriers: 222 cases (1983‐1997). J Vet Intern Med. 2000;14:68‐80.
Dossin O, Lavoue R. Protein‐losing enteropathies in dogs. Vet Clin North Am Small Anim Pract. 2011;41:399‐418.
Craven MD, Washabau RJ. Comparative pathophysiology and management of protein‐losing enteropathy. J Vet Intern Med. 2019;33:383‐402.
Simmerson SM, Armstrong PJ, Wunschmann A, et al. Clinical features, intestinal histopathology, and outcome in protein‐losing enteropathy in Yorkshire terrier dogs. J Vet Intern Med. 2014;28:331‐337.
Kim JH, Bak YT, Kim JS, Seol S, Shin B, Kim H. Clinical significance of duodenal lymphangiectasia incidentally found during routine upper gastrointestinal endoscopy. Endoscopy. 2009;41:510‐515.
Palerme JS, Silverstone A, Riedesel EA, Simone KM, Pomrantz JS. A pilot study on the effect of fat loading on the gastrointestinal tract of healthy dogs. J Small Anim Pract. 2020;61:732‐737.
Willard MD, Moore GE, Denton BD, et al. Effect of tissue processing on assessment of endoscopic intestinal biopsies in dogs and cats. J Vet Intern Med. 2010;24:84‐89.
Willard MD, Jergens AE, Duncan RB, et al. Interobserver variation among histopathologic evaluations of intestinal tissues from dogs and cats. J Am Vet Med Assoc. 2002;220:1177‐1182.
Allenspach KA, Mochel JP, Du Y, et al. Correlating gastrointestinal histopathologic changes to clinical disease activity in dogs with idiopathic inflammatory bowel disease. Vet Pathol. 2019;56:435‐443.
Ovbey DH, Wilson DV, Bednarski RM, et al. Prevalence and risk factors for canine post‐anesthetic aspiration pneumonia (1999‐2009): a multicenter study. Vet Anaesth Analg. 2014;41:127‐136.
Lamata C, Loughton V, Jones M, et al. The risk of passive regurgitation during general anaesthesia in a population of referred dogs in the UK. Vet Anaesth Analg. 2012;39:266‐274.
Lee MM, Jacques A, Lam E, et al. Factors associated with incomplete small bowel capsule endoscopy studies. World J Gastroenterol. 2010;16:5329‐5333.
Rondonotti E, Herrerias JM, Pennazio M, Caunedo A, Mascarenhas‐Saraiva M, de Franchis R. Complications, limitations, and failures of capsule endoscopy: a review of 733 cases. Gastrointest Endosc. 2005;62:712‐716.
Selby W. Complete small‐bowel transit in patients undergoing capsule endoscopy: determining factors and improvement with metoclopramide. Gastrointest Endosc. 2005;61:80‐85.
Leung WK, Chan FK, Fung SS, Wong MY, Sung JJ. Effect of oral erythromycin on gastric and small bowel transit time of capsule endoscopy. World J Gastroenterol. 2005;11:4865‐4868.
Caddy GR, Moran L, Chong AK, et al. The effect of erythromycin on video capsule endoscopy intestinal‐transit time. Gastrointest Endosc. 2006;63:262‐266.
Postgate A, Tekkis P, Patterson N, Fitzpatrick A, Bassett P, Fraser C. Are bowel purgatives and prokinetics useful for small‐bowel capsule endoscopy? A prospective randomized controlled study. Gastrointest Endosc. 2009;69:1120‐1128.
Warrit K, Boscan P, Ferguson LE, et al. Minimally invasive wireless motility capsule to study canine gastrointestinal motility and pH. Vet J. 2017;227:36‐41.
Medical I. Instructions for Use ALICAM® Capsule; 2018. Accessed 20240201. http://www.alicamvet.com/wp-content/uploads/2018/11/Final-Alicam-Booklet_Revised-10_02_2018_IFU2269-RevE.pdf
Zheng Y, Hawkins L, Wolff J, Goloubeva O, Goldberg E. Detection of lesions during capsule endoscopy: physician performance is disappointing. Am J Gastroenterol. 2012;107:554‐560.
Rondonotti E, Soncini M, Girelli CM, et al. Can we improve the detection rate and interobserver agreement in capsule endoscopy? Dig Liver Dis. 2012;44:1006‐1011.
Medical I. 2023. Veterinarian FAQs. Accessed 20240201. http://www.alicamvet.com/for-veterinarians1/
Enns RA, Hookey L, Armstrong D, et al. Clinical practice guidelines for the use of video capsule endoscopy. Gastroenterology. 2017;152:497‐514.
Bouchard S, Ibrahim M, Van Gossum A. Video capsule endoscopy: perspectives of a revolutionary technique. World J Gastroenterol. 2014;20:17330‐17344.
Candido MV, Syrjä P, Kilpinen S, Meisner S, Hanifeh M, Spillmann T. Can chromoendoscopy improve the early diagnosis of gastric carcinoma in dogs? Animals (Basel). 2022;12:12.
Bovens C, Tennant K, Reeve J, Murphy KF. Basal serum cortisol concentration as a screening test for hypoadrenocorticism in dogs. J Vet Intern Med. 2014;28:1541‐1545.