Clinical characteristics, treatment and outcome of clindamycin induced acute generalized exanthematous pustulosis.
Acute generalized exanthematous pustulosis
Clindamycin
Cutaneous drug reaction
Drug allergy
Pustule
Journal
Archives of dermatological research
ISSN: 1432-069X
Titre abrégé: Arch Dermatol Res
Pays: Germany
ID NLM: 8000462
Informations de publication
Date de publication:
24 Aug 2024
24 Aug 2024
Historique:
received:
25
06
2024
accepted:
05
08
2024
revised:
10
07
2024
medline:
24
8
2024
pubmed:
24
8
2024
entrez:
24
8
2024
Statut:
epublish
Résumé
Acute generalized exanthematous pustulosis (AGEP) is a serious and rare adverse reaction to clindamycin. This study investigated the clinical features of clindamycin-induced AGEP and provided reference for the prevention and treatment of AGEP. Case reports, case series and clinical studies of clindamycin-induced AGEP were collected by retrieving English and Chinese database from inception until May 31, 2024. Of the 35 patients included, 25 (71.4%) were female, and the median age was 57 years (1.6-88 years). The duration of AGEP onset is 2 days (range 0.04,13) after initial administration. The main clinical morphology of AGEP is a non-follicular pustular on an erythematous base, which may be accompanied by fever (54.3%) and pruritus (40.0%). These lesions mainly involved extremities and trunk. The median elevated neutrophil count was 13.3 × 10
Identifiants
pubmed: 39180541
doi: 10.1007/s00403-024-03310-8
pii: 10.1007/s00403-024-03310-8
doi:
Substances chimiques
Clindamycin
3U02EL437C
Anti-Bacterial Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
573Subventions
Organisme : Natural Science Foundation of Hunan Province
ID : 2023JJ30847
Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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