Onset of Spontaneous Filling and Voiding Cycles in the Lower Urinary Tract: A Modeling Study.
Filling voiding cycles
Lower urinary tract
Mathematical modeling
Mathematical modeling of organ function
Journal
Bulletin of mathematical biology
ISSN: 1522-9602
Titre abrégé: Bull Math Biol
Pays: United States
ID NLM: 0401404
Informations de publication
Date de publication:
24 Aug 2024
24 Aug 2024
Historique:
received:
25
10
2023
accepted:
03
06
2024
medline:
24
8
2024
pubmed:
24
8
2024
entrez:
24
8
2024
Statut:
epublish
Résumé
Spontaneous filling and voiding cycles represent a key dynamical feature of the healthy lower urinary tract. Some urinary tract dysfunctions, such as over-flow incontinence, may alter the natural occurrence of these cycles. As the function of the lower urinary tract arises from the interplay of a multitude of factors, it is difficult to determine which of them can be modulated to regain spontaneous cycles. In this study, we develop a mathematical model of the lower urinary tract that can capture filling and voiding cycles in the form of periodic solutions of a system of ordinary differential equations. After experimental validation, we utilize this model to study the effect that several physiological quantities have on the onset of cycles. We find that some parameters have an associated numerical threshold that determines whether the system exhibits healthy cycles or settles in a state of constant overflow.
Identifiants
pubmed: 39180612
doi: 10.1007/s11538-024-01320-1
pii: 10.1007/s11538-024-01320-1
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
122Subventions
Organisme : NIH HHS
ID : NIH OT2OD030524
Pays : United States
Organisme : NIH HHS
ID : NIH R01DK133605
Pays : United States
Informations de copyright
© 2024. The Author(s), under exclusive licence to the Society for Mathematical Biology.
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