Metabolic signatures derived from whole-brain MR-spectroscopy identify early tumor progression in high-grade gliomas using machine learning.

Binary classification Glioblastoma Machine learning Multiclass classifier Predictive models Whole-brain magnetic resonance spectroscopy (WB-MRS)

Journal

Journal of neuro-oncology
ISSN: 1573-7373
Titre abrégé: J Neurooncol
Pays: United States
ID NLM: 8309335

Informations de publication

Date de publication:
24 Aug 2024
Historique:
received: 03 03 2024
accepted: 19 08 2024
medline: 24 8 2024
pubmed: 24 8 2024
entrez: 24 8 2024
Statut: aheadofprint

Résumé

Recurrence for high-grade gliomas is inevitable despite maximal safe resection and adjuvant chemoradiation, and current imaging techniques fall short in predicting future progression. However, we introduce a novel whole-brain magnetic resonance spectroscopy (WB-MRS) protocol that delves into the intricacies of tumor microenvironments, offering a comprehensive understanding of glioma progression to inform expectant surgical and adjuvant intervention. We investigated five locoregional tumor metabolites in a post-treatment population and applied machine learning (ML) techniques to analyze key relationships within seven regions of interest: contralateral normal-appearing white matter (NAWM), fluid-attenuated inversion recovery (FLAIR), contrast-enhancing tumor at time of WB-MRS (Tumor), areas of future recurrence (AFR), whole-brain healthy (WBH), non-progressive FLAIR (NPF), and progressive FLAIR (PF). Five supervised ML classification models and a neural network were developed, optimized, trained, tested, and validated. Lastly, a web application was developed to host our novel calculator, the Miami Glioma Prediction Map (MGPM), for open-source interaction. Sixteen patients with histopathological confirmation of high-grade glioma prior to WB-MRS were included in this study, totaling 118,922 whole-brain voxels. ML models successfully differentiated normal-appearing white matter from tumor and future progression. Notably, the highest performing ML model predicted glioma progression within fluid-attenuated inversion recovery (FLAIR) signal in the post-treatment setting (mean AUC = 0.86), with Cho/Cr as the most important feature. This study marks a significant milestone as the first of its kind to unveil radiographic occult glioma progression in post-treatment gliomas within 8 months of discovery. These findings underscore the utility of ML-based WB-MRS growth predictions, presenting a promising avenue for the guidance of early treatment decision-making. This research represents a crucial advancement in predicting the timing and location of glioblastoma recurrence, which can inform treatment decisions to improve patient outcomes.

Identifiants

pubmed: 39180640
doi: 10.1007/s11060-024-04812-1
pii: 10.1007/s11060-024-04812-1
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIH HHS
ID : R01CA172210, R01EB016064
Pays : United States
Organisme : NIH HHS
ID : R01CA172210, R01EB016064
Pays : United States
Organisme : NIH HHS
ID : R01CA172210, R01EB016064
Pays : United States
Organisme : NIH HHS
ID : R01CA172210, R01EB016064
Pays : United States
Organisme : NIH HHS
ID : R01CA172210, R01EB016064
Pays : United States
Organisme : NIH HHS
ID : R01CA172210, R01EB016064
Pays : United States
Organisme : NIH HHS
ID : R01CA172210, R01EB016064
Pays : United States
Organisme : NIH HHS
ID : R01CA172210, R01EB016064
Pays : United States
Organisme : NIH HHS
ID : R01CA172210, R01EB016064
Pays : United States
Organisme : NIH HHS
ID : R01CA172210, R01EB016064
Pays : United States
Organisme : NIH HHS
ID : R01CA172210, R01EB016064
Pays : United States
Organisme : NIH HHS
ID : R01CA172210, R01EB016064
Pays : United States
Organisme : NIH HHS
ID : R01CA172210, R01EB016064
Pays : United States
Organisme : NIH HHS
ID : R01CA172210, R01EB016064
Pays : United States
Organisme : NIH HHS
ID : R01CA172210, R01EB016064
Pays : United States
Organisme : NIH HHS
ID : R01CA172210, R01EB016064
Pays : United States
Organisme : NIH HHS
ID : R01CA172210, R01EB016064
Pays : United States
Organisme : NIH HHS
ID : R01CA172210, R01EB016064
Pays : United States
Organisme : NIH HHS
ID : R01CA172210, R01EB016064
Pays : United States
Organisme : NIH HHS
ID : R01CA172210, R01EB016064
Pays : United States

Informations de copyright

© 2024. The Author(s).

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Auteurs

Cameron A Rivera (CA)

Department of Neurosurgery, University of Miami Miller School of Medicine, Miami, FL, USA. car909@med.miami.edu.

Shovan Bhatia (S)

Department of Neurosurgery, University of Miami Miller School of Medicine, Miami, FL, USA.
Department of Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Alexis A Morell (AA)

Department of Neurosurgery, University of Miami Miller School of Medicine, Miami, FL, USA.
Department of Critical Care, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Lekhaj C Daggubati (LC)

Department of Neurosurgery, University of Miami Miller School of Medicine, Miami, FL, USA.
Surgical Neuro-Oncology, District of Columbia, George Washington Medical Faculty Associates, Washington, USA.

Martin A Merenzon (MA)

Department of Neurosurgery, University of Miami Miller School of Medicine, Miami, FL, USA.
Department of Neurosurgery, Yale University School of Medicine, New Haven, CT, USA.

Sulaiman A Sheriff (SA)

Department of Radiation Oncology, University of Miami Miller School of Medicine, Miami, FL, USA.
Department of Radiology, University of Miami Miller School of Medicine, Miami, FL, USA.

Evan Luther (E)

Department of Neurosurgery, University of Miami Miller School of Medicine, Miami, FL, USA.
Department of Neurosurgery, Allegheny Health Network, Pittsburgh, PA, USA.

Jay Chandar (J)

Department of Neurosurgery, University of Miami Miller School of Medicine, Miami, FL, USA.
Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA.

Adam S Levy (A)

Department of Neurosurgery, University of Miami Miller School of Medicine, Miami, FL, USA.

Ashley R Metzler (AR)

Department of Neurosurgery, University of Miami Miller School of Medicine, Miami, FL, USA.

Chandler N Berke (CN)

Department of Neurosurgery, University of Miami Miller School of Medicine, Miami, FL, USA.

Mohammed Goryawala (M)

Department of Radiology, University of Miami Miller School of Medicine, Miami, FL, USA.

Eric A Mellon (EA)

Department of Radiation Oncology, University of Miami Miller School of Medicine, Miami, FL, USA.
Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, 1475 NW 12th Ave, Miami, FL, USA.

Rita G Bhatia (RG)

Department of Radiology, University of Miami Miller School of Medicine, Miami, FL, USA.

Natalya Nagornaya (N)

Department of Radiology, University of Miami Miller School of Medicine, Miami, FL, USA.

Gaurav Saigal (G)

Department of Radiology, University of Miami Miller School of Medicine, Miami, FL, USA.

Macarena I de la Fuente (M)

Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, 1475 NW 12th Ave, Miami, FL, USA.
Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA.

Ricardo J Komotar (RJ)

Department of Neurosurgery, University of Miami Miller School of Medicine, Miami, FL, USA.
Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, 1475 NW 12th Ave, Miami, FL, USA.

Michael E Ivan (ME)

Department of Neurosurgery, University of Miami Miller School of Medicine, Miami, FL, USA.
Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, 1475 NW 12th Ave, Miami, FL, USA.

Ashish H Shah (AH)

Department of Neurosurgery, University of Miami Miller School of Medicine, Miami, FL, USA.
Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, 1475 NW 12th Ave, Miami, FL, USA.

Classifications MeSH