Immune suppression by human thymus-derived effector Tregs relies on glucose/lactate-fueled fatty acid synthesis.

(regulatory) T cell CP: Immunology CP: Metabolism costimulation fatty acids glycolysis immune suppression isotopologue tracing lactate lipidomics mass spectrometry metabolism

Journal

Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691

Informations de publication

Date de publication:
23 Aug 2024
Historique:
received: 18 03 2024
revised: 10 07 2024
accepted: 08 08 2024
medline: 24 8 2024
pubmed: 24 8 2024
entrez: 24 8 2024
Statut: aheadofprint

Résumé

Regulatory T cells (Tregs) suppress pro-inflammatory conventional T cell (Tconv) responses. As lipids impact cell signaling and function, we compare the lipid composition of CD4

Identifiants

DOI: 10.1016/j.celrep.2024.114681 PMID: 39180751
pubmed: 39180751
pii: S2211-1247(24)01032-5
doi: 10.1016/j.celrep.2024.114681
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

114681

Informations de copyright

Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

Auteurs

Sander de Kivit (S)

Department of Immunology, Leiden University Medical Center, 2300 RC Leiden, the Netherlands; Oncode Institute, Leiden University Medical Center, 2300 RC Leiden, the Netherlands. Electronic address: s.de_kivit@lumc.nl.

Mark Mensink (M)

Department of Immunology, Leiden University Medical Center, 2300 RC Leiden, the Netherlands; Oncode Institute, Leiden University Medical Center, 2300 RC Leiden, the Netherlands.

Sarantos Kostidis (S)

Center for Proteomics and Metabolomics, Leiden University Medical Center, 2300 RC Leiden, the Netherlands.

Rico J E Derks (RJE)

Center for Proteomics and Metabolomics, Leiden University Medical Center, 2300 RC Leiden, the Netherlands.

Esther A Zaal (EA)

Division of Cell Biology, Metabolism, and Cancer, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, 3584 CM Utrecht, the Netherlands.

Marieke Heijink (M)

Center for Proteomics and Metabolomics, Leiden University Medical Center, 2300 RC Leiden, the Netherlands.

Lotte J Verleng (LJ)

Department of Immunology, Leiden University Medical Center, 2300 RC Leiden, the Netherlands; Oncode Institute, Leiden University Medical Center, 2300 RC Leiden, the Netherlands.

Evert de Vries (E)

Department of Immunology, Leiden University Medical Center, 2300 RC Leiden, the Netherlands; Oncode Institute, Leiden University Medical Center, 2300 RC Leiden, the Netherlands.

Ellen Schrama (E)

Department of Immunology, Leiden University Medical Center, 2300 RC Leiden, the Netherlands; Oncode Institute, Leiden University Medical Center, 2300 RC Leiden, the Netherlands.

Niek Blomberg (N)

Center for Proteomics and Metabolomics, Leiden University Medical Center, 2300 RC Leiden, the Netherlands.

Celia R Berkers (CR)

Division of Cell Biology, Metabolism, and Cancer, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, 3584 CM Utrecht, the Netherlands.

Martin Giera (M)

Center for Proteomics and Metabolomics, Leiden University Medical Center, 2300 RC Leiden, the Netherlands.

Jannie Borst (J)

Department of Immunology, Leiden University Medical Center, 2300 RC Leiden, the Netherlands; Oncode Institute, Leiden University Medical Center, 2300 RC Leiden, the Netherlands. Electronic address: j.g.borst@lumc.nl.

Classifications MeSH