Cytosine methylation flags mitochondrial RNA for degradation.
5-methylcytosine
RNA degradation
dsRNA
immunity
mitochondrial RNA
nucleic acid sensing
Journal
Trends in biochemical sciences
ISSN: 0968-0004
Titre abrégé: Trends Biochem Sci
Pays: England
ID NLM: 7610674
Informations de publication
Date de publication:
23 Aug 2024
23 Aug 2024
Historique:
received:
26
07
2024
revised:
13
08
2024
accepted:
13
08
2024
medline:
26
8
2024
pubmed:
26
8
2024
entrez:
24
8
2024
Statut:
aheadofprint
Résumé
Mitochondrial double-stranded RNA (dsRNA) can form spontaneously in mitochondria, blocking mitochondrial gene expression and triggering an immune response. A recent study by Kim, Tan, et al. identified a safeguard mechanism in which NOP2/Sun RNA methyltransferase 4 (NSUN4)-mediated RNA methylation (m
Identifiants
pubmed: 39181838
pii: S0968-0004(24)00188-9
doi: 10.1016/j.tibs.2024.08.001
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests No interests are declared.