Warthin tumor concomitant with mantle cell lymphoma: a case report and review of literature.
Hodgkin lymphoma
Lymph node
Mantle cell lymphoma
Non-Hodgkin lymphoma
Parotid gland
Warthin tumor
Journal
Diagnostic pathology
ISSN: 1746-1596
Titre abrégé: Diagn Pathol
Pays: England
ID NLM: 101251558
Informations de publication
Date de publication:
24 Aug 2024
24 Aug 2024
Historique:
received:
03
07
2024
accepted:
18
08
2024
medline:
26
8
2024
pubmed:
26
8
2024
entrez:
24
8
2024
Statut:
epublish
Résumé
Warthin tumor (WT) is the second most common benign tumor in salivary gland. It has a slow growth rate and most frequently occurs in the parotid gland. Most patients present with an incidental finding of a painless mass inferior/anterior to the ear. Besides the epithelial component of the tumor, WT is characteristically associated with lymphoid stroma that is considered benign. While there have been a few reports of malignant transformation of the lymphoid components in WT, cases of WT concomitant with mantle cell lymphoma (MCL) are extremely rare. To the best of our knowledge, two cases have been described in the English literature. Herein, we report a case of WT concomitant with MCL in a 70-year-old female patient, and emphasize the importance of careful examination of lymphoid stroma in WT so that concurrent lymphoma is not missed. A 70-year-old Chinese woman with a 40-year history of cigarette smoking presented with a one year history of a right submaxillary mass with recent enlargement. Cervical ultrasound (US) and computed tomography (CT) scans of the neck revealed a well-circumscribed mass in the right parotid with a maximum diameter of 3.1 cm. Surgical resection of the mass was performed. Histopathological examination revealed a characteristic double-layer of neoplastic epithelium with prominent lymphoid stroma, suggesting WT. In addition, morphology and immunohistochemistry studies confirmed the coexistence of MCL. Thereafter, the final diagnosis of this case was WT concomitant with MCL. The patient was staged as stage I after clinical assessment. Due to the slow growth of parotid lesions, close observation was decided with periodic clinical and radiological monitoring. Currently, the patient demonstrates a stable disease by clinical evaluation. To the best of our knowledge, reported cases of WT concomitant with MCL are very rare. This case highlights the importance of a comprehensive assessment of the lymphoid stroma of WT to avoid missed diagnosis of a lymphoma component in a collision tumor.
Identifiants
pubmed: 39182117
doi: 10.1186/s13000-024-01538-6
pii: 10.1186/s13000-024-01538-6
doi:
Types de publication
Case Reports
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
114Subventions
Organisme : Natural Science Fund of Liaoning Province
ID : Grant No. 2020-MS-142 to S. Ma
Organisme : Natural Science Fund of Liaoning Province
ID : Grant No. 2019JH3/10300420 and 2019-MS-374 to L.-H. Yang
Organisme : Natural Fund Guidance Plan of Liaoning Provincial Science and Technology Department
ID : Grant No.2019-ZD-0735 to S. Ma
Organisme : 345 Talent Project of Shengjing Hospital of China Medical University
ID : Grant No. M0364 to S. Ma
Organisme : National Natural Science Foundation of China
ID : Grant No. 81301930 to L.-H. Yang
Organisme : General project of Education Department of Liaoning Province
ID : Grant No. L2015595 to L.-H. Yang
Organisme : Key R&D Program Projects of Liaoning Province
ID : Grant No. 2018225085 to L.-H. Yang
Organisme : Supporting the high-quality development of science and technology funding projects in China Medical University
ID : 2023020778-JH2/202, to L.-H. Yang
Informations de copyright
© 2024. The Author(s).
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