The importance of Haemophilus influenzae in community-acquired pneumonia: an emerging pathogen in the elderly regardless of comorbidities compared to Streptococcus pneumoniae.
Haemophilus influenzae
Streptococcus pneumoniae
CAP
Community acquired pneumonia
Pneumonia
Journal
Pneumonia (Nathan Qld.)
ISSN: 2200-6133
Titre abrégé: Pneumonia (Nathan)
Pays: England
ID NLM: 101663459
Informations de publication
Date de publication:
25 Aug 2024
25 Aug 2024
Historique:
received:
15
12
2023
accepted:
19
06
2024
medline:
26
8
2024
pubmed:
26
8
2024
entrez:
24
8
2024
Statut:
epublish
Résumé
Haemophilus influenzae community-acquired pneumonia (CAP) is common, and it is equally common to Streptococcus pneumoniae in some settings. The purpose of this study was to provide additional data on patients affected by H. influenzae CAP and their outcomes. Streptococcus pneumoniae-caused CAP (111 cases) was compared to CAP with H. influenzae (53 cases). Patients were adults (≥ 18 years) from the prospective study "Etiology of community acquired pneumonia in Sweden" (ECAPS), which was established during the years 2016-2018. Cases with H. influenzae CAP were significantly older compared to S. pneumoniae CAP (median 77 vs 70 years, p = 0.037) albeit similar comorbidities. Haemophilus influenzae was generally absent in the bloodstream compared to S. pneumoniae (18% vs 2%, p = 0.01) but clinical presentations were comparable. Only a minority of patients, 34% with H. influenzae and 41% with S. pneumoniae CAP had underlying lung disease. In the light of childhood immunization campaigns against S. pneumoniae and the increasing numbers of pneumococcal vaccinations among the elderly, coupled with an aging population, the incidence of CAP caused by H. influenzae may increase. Further research is needed to understand the impact of H. influenzae CAP and to a development of a vaccine against this emerging microbe.
Sections du résumé
BACKGROUND
BACKGROUND
Haemophilus influenzae community-acquired pneumonia (CAP) is common, and it is equally common to Streptococcus pneumoniae in some settings. The purpose of this study was to provide additional data on patients affected by H. influenzae CAP and their outcomes.
METHODS
METHODS
Streptococcus pneumoniae-caused CAP (111 cases) was compared to CAP with H. influenzae (53 cases). Patients were adults (≥ 18 years) from the prospective study "Etiology of community acquired pneumonia in Sweden" (ECAPS), which was established during the years 2016-2018.
RESULTS
RESULTS
Cases with H. influenzae CAP were significantly older compared to S. pneumoniae CAP (median 77 vs 70 years, p = 0.037) albeit similar comorbidities. Haemophilus influenzae was generally absent in the bloodstream compared to S. pneumoniae (18% vs 2%, p = 0.01) but clinical presentations were comparable. Only a minority of patients, 34% with H. influenzae and 41% with S. pneumoniae CAP had underlying lung disease.
CONCLUSION
CONCLUSIONS
In the light of childhood immunization campaigns against S. pneumoniae and the increasing numbers of pneumococcal vaccinations among the elderly, coupled with an aging population, the incidence of CAP caused by H. influenzae may increase. Further research is needed to understand the impact of H. influenzae CAP and to a development of a vaccine against this emerging microbe.
Identifiants
pubmed: 39182132
doi: 10.1186/s41479-024-00136-w
pii: 10.1186/s41479-024-00136-w
doi:
Types de publication
Journal Article
Langues
eng
Pagination
15Subventions
Organisme : Hjärt-Lungfonden
ID : 20180401
Organisme : Vetenskapsrådet
ID : 2019-01053
Organisme : Knut och Alice Wallenbergs Stiftelse
ID : 2018.0318
Informations de copyright
© 2024. The Author(s).
Références
Shoar S, Musher DM. Etiology of community-acquired pneumonia in adults: a systematic review. Pneumonia (Nathan). 2020;12:11.
doi: 10.1186/s41479-020-00074-3
pubmed: 33024653
Gadsby NJ, Russell CD, McHugh MP, Mark H, Conway Morris A, Laurenson IF, et al. Comprehensive Molecular Testing for Respiratory Pathogens in Community-Acquired Pneumonia. Clin Infect Dis. 2016;62(7):817–23.
doi: 10.1093/cid/civ1214
pubmed: 26747825
Fally M, Israelsen S, Anhøj J, Benfield T, Tarp B, Kolte L, et al. The increasing importance of Haemophilus influenzae in community-acquired pneumonia: results from a Danish cohort study. Infect Dis. 2021;53(2):122–30.
doi: 10.1080/23744235.2020.1846776
Resman F, Ristovski M, Ahl J, Forsgren A, Gilsdorf JR, Jasir A, et al. Invasive disease caused by Haemophilus influenzae in Sweden 1997–2009; evidence of increasing incidence and clinical burden of non-type b strains. Clin Microbiol Infect. 2011;17(11):1638–45.
doi: 10.1111/j.1469-0691.2010.03417.x
pubmed: 21054663
Livorsi DJ, Macneil JR, Cohn AC, Bareta J, Zansky S, Petit S, et al. Invasive Haemophilus influenzae in the United States, 1999–2008: epidemiology and outcomes. J Infect. 2012;65(6):496–504.
doi: 10.1016/j.jinf.2012.08.005
pubmed: 22902945
pmcid: 4329643
Hansen K, Yamba Yamba L, Wasserstrom L, Rünow E, Göransson T, Nilsson A, et al. Exploring the microbial landscape: uncovering the pathogens associated with community-acquired pneumonia in hospitalized patients. Front Public Health. 2023;11:1258981.
doi: 10.3389/fpubh.2023.1258981
pubmed: 38152664
pmcid: 10752608
Hansen K, Rünow E, Torisson G, Theilacker C, Palmborg A, Pan K, et al. Radiographically confirmed community-acquired pneumonia in hospitalized adults due to pneumococcal vaccine serotypes in Sweden, 2016–2018—The ECAPS study. Front Public Health. 2023;11:1086648.
doi: 10.3389/fpubh.2023.1086648
pubmed: 36875379
pmcid: 9981934
Forstner C, Rohde G, Rupp J, Schuette H, Ott SR, Hagel S, et al. Community-acquired Haemophilus influenzae pneumonia - New insights from the CAPNETZ study. J Infect. 2016;72(5):554–63.
doi: 10.1016/j.jinf.2016.02.010
pubmed: 26940505
Shoar S, Centeno FH, Musher DM. Clinical Features and Outcomes of Community-Acquired Pneumonia Caused by Haemophilus influenzae. Open Forum Infect Dis. 2021;8(4):ofaa622.
doi: 10.1093/ofid/ofaa622
pubmed: 33855100
pmcid: 8028099
Thegerström J, Månsson V, Riesbeck K, Resman F. Benzylpenicillin versus wide-spectrum beta-lactam antibiotics as empirical treatment of Haemophilus influenzae-associated lower respiratory tract infections in adults; a retrospective propensity score-matched study. Eur J Clin Microbiol Infect Dis. 2018;37(9):1761–75.
doi: 10.1007/s10096-018-3311-x
pubmed: 29961165
pmcid: 6133041
Månsson V, Skaare D, Riesbeck K, Resman F. The spread and clinical impact of ST14CC-PBP3 type IIb/A, a clonal group of non-typeable Haemophilus influenzae with chromosomally mediated β-lactam resistance-a prospective observational study. Clin Microbiol Infect. 2017;23(3):209.e1–209.e7.
doi: 10.1016/j.cmi.2016.11.006
pubmed: 27852000
Tsoumani E, Carter JA, Salomonsson S, Stephens JM, Bencina G. Clinical, economic, and humanistic burden of community acquired pneumonia in Europe: a systematic literature review. Expert Rev Vaccines. 2023;22(1):876–84.
doi: 10.1080/14760584.2023.2261785
pubmed: 37823894
Mangen MJJ, Huijts SM, Bonten MJM, de Wit GA. The impact of community-acquired pneumonia on the health-related quality-of-life in elderly. BMC Infectious Diseases. 2017;17(1):208.
doi: 10.1186/s12879-017-2302-3
pubmed: 28292280
pmcid: 5351062
Eurostat. Population projections in the EU - statistics explained. https://ec.europa.eu/eurostat/statistics-explained/index.php?oldid=497115 . Accessed 31 Oct 2023.
Camilli R, Vescio MF, Giufrè M, Daprai L, Garlaschi ML, Cerquetti M, et al. Carriage of Haemophilus influenzae is associated with pneumococcal vaccination in Italian children. Vaccine. 2015;33(36):4559–64.
doi: 10.1016/j.vaccine.2015.07.009
pubmed: 26190092
van Deursen AMM, van Houten MA, Webber C, Patton M, Scott D, Patterson S, et al. The Impact of the 13-Valent Pneumococcal Conjugate Vaccine on Pneumococcal Carriage in the Community Acquired Pneumonia Immunization Trial in Adults (CAPiTA) Study. Clin Infect Dis. 2018;67(1):42–9.
doi: 10.1093/cid/ciy009
pubmed: 29324986
Athlin S, Lidman C, Lundqvist A, Naucler P, Nilsson AC, Spindler C, et al. Management of community-acquired pneumonia in immunocompetent adults: updated Swedish guidelines 2017. Infect Dis. 2018;50(4):247–72.
doi: 10.1080/23744235.2017.1399316
Giufre M, Dorrucci M, Lo Presti A, Farchi F, Cardines R, Camilli R, et al. Nasopharyngeal carriage of Haemophilus influenzae among adults with co-morbidities. Vaccine. 2022;40(5):826–32.
doi: 10.1016/j.vaccine.2021.12.030
pubmed: 34952754
Public Health Agency of Sweden. Haemophilus influenzae (invasiv) – sjukdomsstatistik. https://www.folkhalsomyndigheten.se/folkhalsorapportering-statistik/statistik-a-o/sjukdomsstatistik/haemophilus-influenzae-invasiv . Accessed 29 May 2024.