A case of severe Aicardi-Goutières syndrome with a homozygous RNASEH2B intronic variant.


Journal

Human genome variation
ISSN: 2054-345X
Titre abrégé: Hum Genome Var
Pays: England
ID NLM: 101652445

Informations de publication

Date de publication:
26 Aug 2024
Historique:
received: 09 07 2024
accepted: 28 07 2024
revised: 26 07 2024
medline: 26 8 2024
pubmed: 26 8 2024
entrez: 25 8 2024
Statut: epublish

Résumé

We report a case of severe Aicardi-Goutières syndrome caused by a novel homozygous RNASEH2B intronic variant, NC_000013.10(NM_024570.4):c.65-13G > A p.Glu22Valfs*5. The patient was born with pseudo-TORCH symptoms, including intracranial calcification, cataracts, and hepatosplenomegaly. Furthermore, the patient exhibited profound intellectual impairment and died at 14 months due to aspiration pneumonia accompanied by interstitial lung abnormalities. The severity of the patient's symptoms underscores the critical role of the C-terminal region of RNase H2B.

Identifiants

pubmed: 39183359
doi: 10.1038/s41439-024-00291-y
pii: 10.1038/s41439-024-00291-y
doi:

Types de publication

Journal Article

Langues

eng

Pagination

33

Subventions

Organisme : Japan Agency for Medical Research and Development (AMED)
ID : im0210625h0001, 17ek0109270s0301, 21ek0109511h0001, 22ek0109511h0002, and 23ek0109511h0003
Organisme : Japan Agency for Medical Research and Development (AMED)
ID : JP24ek0109674, JP24ek0109760, JP24ek0109617, JP24ek0109648, and JP24ek0109677
Organisme : MEXT | Japan Society for the Promotion of Science (JSPS)
ID : JP23K27568
Organisme : MEXT | Japan Society for the Promotion of Science (JSPS)
ID : JP24K02230

Informations de copyright

© 2024. The Author(s).

Références

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Auteurs

Yuri Shibata (Y)

Department of Pediatrics, Sano Kosei General Hospital, Tochigi, Japan.
Department of Pediatrics, Jichi Medical University, Tochigi, Japan.

Akimichi Shibata (A)

Department of Pediatrics, Japanese Red Cross Ashikaga Hospital, Tochigi, Japan.

Takeshi Mizuguchi (T)

Department of Human Genetics, Yokohama City University Graduate School of Medicine, Kanagawa, Japan.

Naomichi Matsumoto (N)

Department of Human Genetics, Yokohama City University Graduate School of Medicine, Kanagawa, Japan.

Hitoshi Osaka (H)

Department of Pediatrics, Jichi Medical University, Tochigi, Japan. hosaka@jichi.ac.jp.

Classifications MeSH