Emerging targets for positron emission tomography imaging in proteinopathies.

Brain imaging Imaging techniques

Journal

Npj imaging
ISSN: 2948-197X
Titre abrégé: Npj Imaging
Pays: Switzerland
ID NLM: 9918733285306676

Informations de publication

Date de publication:
2024
Historique:
received: 12 04 2024
accepted: 16 07 2024
medline: 26 8 2024
pubmed: 26 8 2024
entrez: 26 8 2024
Statut: ppublish

Résumé

Positron emission tomography (PET) imaging of neurodegenerative disease has historically focused on a small number of established targets. The development of selective PET radiotracers for novel biological targets enables new ways to interrogate the neuropathology of proteinopathies and will advance our understanding of neurodegeneration. This perspective aims to highlight recent PET radiotracers developed for five emerging targets in proteinopathies (i.e., mHTT, BACE1, TDP-43, OGA, and CH24H).

Identifiants

DOI: 10.1038/s44303-024-00032-4 PMID: 39185440 PMC: PMC11338821
pubmed: 39185440
doi: 10.1038/s44303-024-00032-4
pii: 32
pmc: PMC11338821
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

30

Informations de copyright

© The Author(s) 2024.

Déclaration de conflit d'intérêts

Competing interestsThe authors declare no competing interests.

Auteurs

Melissa Chassé (M)

Azrieli Centre for Neuro-Radiochemistry, Brain Health Imaging Centre, Centre for Addiction and Mental Health, Campbell Family Mental Health Research Institute, Toronto, ON Canada.
Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, ON Canada.

Neil Vasdev (N)

Azrieli Centre for Neuro-Radiochemistry, Brain Health Imaging Centre, Centre for Addiction and Mental Health, Campbell Family Mental Health Research Institute, Toronto, ON Canada.
Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, ON Canada.

Classifications MeSH