The Impact of LPS on Inflammatory Responses in Alpha-Tocopherol Deficient Mice.
RRR-α-tocopherol
Ttpa-null mouse
inflammation
lipopolysaccharide
oxidative stress
sickness behaviors
vitamin E
Journal
Current developments in nutrition
ISSN: 2475-2991
Titre abrégé: Curr Dev Nutr
Pays: United States
ID NLM: 101717957
Informations de publication
Date de publication:
Aug 2024
Aug 2024
Historique:
received:
12
04
2024
revised:
17
06
2024
accepted:
10
07
2024
medline:
26
8
2024
pubmed:
26
8
2024
entrez:
26
8
2024
Statut:
epublish
Résumé
To facilitate the evaluation of vitamin E (α-tocopherol, αT) status on health outcomes, the αT transfer protein knockout ( The objective was to examine whether 12 wk of an αT-deficient diet altered the inflammatory response 4 and/or 24 h after LPS injection in WT and WT and αT concentrations in the brain, liver, and serum of A 4-h LPS challenge reduced grip strength and resulted in an inflammatory response. At 24 h post-dosing, there was a partial, transitory recovery response in both
Sections du résumé
Background
UNASSIGNED
To facilitate the evaluation of vitamin E (α-tocopherol, αT) status on health outcomes, the αT transfer protein knockout (
Objectives
UNASSIGNED
The objective was to examine whether 12 wk of an αT-deficient diet altered the inflammatory response 4 and/or 24 h after LPS injection in WT and
Methods
UNASSIGNED
WT and
Results
UNASSIGNED
αT concentrations in the brain, liver, and serum of
Conclusions
UNASSIGNED
A 4-h LPS challenge reduced grip strength and resulted in an inflammatory response. At 24 h post-dosing, there was a partial, transitory recovery response in both
Identifiants
pubmed: 39185446
doi: 10.1016/j.cdnut.2024.104416
pii: S2475-2991(24)02350-3
pmc: PMC11342875
doi:
Types de publication
Journal Article
Langues
eng
Pagination
104416Informations de copyright
© 2024 The Authors.