[Prediction and timely identification of postpartum depression: results of the longitudinal RiPoD study in the context of the literature].
Vorhersage und frühzeitige Identifikation einer postpartalen Depression: Ergebnisse der longitudinalen RiPoD-Studie im Kontext der Literatur.
Brain imaging
Depression
Longitudinal
Postpartum
Prediction
Journal
Der Nervenarzt
ISSN: 1433-0407
Titre abrégé: Nervenarzt
Pays: Germany
ID NLM: 0400773
Informations de publication
Date de publication:
26 Aug 2024
26 Aug 2024
Historique:
accepted:
08
07
2024
medline:
26
8
2024
pubmed:
26
8
2024
entrez:
26
8
2024
Statut:
aheadofprint
Résumé
The first 4-6 weeks after childbirth are defined as the onset time for postpartum depression (PPD). Despite this known time frame there are significant gaps in the identification and treatment of PPD. The risk for postpartum depression (RiPoD) study investigated specific risk factors and predictors of postpartum psychological adjustment processes and the results are presented within the framework of a state of the art review of research. The dynamic neuroplastic changes in the maternal brain during pregnancy and the postpartum period appear to be closely linked to peripartum hormone fluctuations, which jointly influence the development of postpartum mood disorders. Hormonal risk factors such as baby blues and premenstrual syndrome have been found to have a bearing on PPD. The combination of these two factors predicts the risk of PPD with 83% sensitivity within the first week postpartum. Follow-up digital monitoring of symptom development in the first 6 weeks postpartum has enabled an accurate identification of women with PPD. Understanding the interaction between hormone fluctuations, neuroplasticity and psychiatric disorders should be an important target for future research. Early identification and diagnosis of PPD can be easily integrated into the clinical routine and everyday life. Die ersten 4 bis 6 Wochen nach der Geburt werden als Zeitfenster für den Beginn der postpartalen Depression (PPD) definiert. Trotz dieses bekannten Zeitfensters gibt es gravierende Lücken in der Identifizierung und Behandlung der PPD. In der Studie „Risk for Postpartum Depression“ (RiPoD) untersuchten wir spezifische Risikofaktoren und Prädiktoren für postpartale psychische Anpassungsprozesse und stellen die Ergebnisse dieser Studie im Rahmen einer Übersichtsarbeit zum internationalen Forschungsstand vor. Die dynamischen neuroplastischen Veränderungen des mütterlichen Gehirns in der Schwangerschaft und im Wochenbett scheinen in enger Verbindung mit peripartal fluktuierenden Hormonspiegeln zu stehen und diese könnten gemeinsam die Entwicklung postpartaler Stimmungsphänomene beeinflussen. Zu den relevanten Einflussgrößen der PPD gehören hormonelle Risikofaktoren, wie der Babyblues und das prämenstruelle Syndrom. Die Kombination beider Faktoren ermöglicht es, das individuelle PPD-Risiko mit einer Sensitivität von 83 % in der ersten Woche postpartum vorherzusagen. Eine anschließende digitale Überwachung der Symptomentwicklung in den ersten 6 Wochen postpartal erlaubte eine präzise Identifikation von Frauen mit PPD. Das Verständnis der Interaktion von hormonellen Schwankungen, Neuroplastizität und psychiatrischen Störungen bietet einen wichtigen Ansatzpunkt für zukünftige Forschungen. Die frühzeitige Identifikation und Diagnose der PPD sowie kritischer Risikofaktoren lassen sich leicht in die klinische Routine und den Alltag der Patientinnen integrieren, wodurch Frauen mit hohem Risiko für eine gezielte Überwachung identifiziert werden können.
Autres résumés
Type: Publisher
(ger)
Die ersten 4 bis 6 Wochen nach der Geburt werden als Zeitfenster für den Beginn der postpartalen Depression (PPD) definiert. Trotz dieses bekannten Zeitfensters gibt es gravierende Lücken in der Identifizierung und Behandlung der PPD. In der Studie „Risk for Postpartum Depression“ (RiPoD) untersuchten wir spezifische Risikofaktoren und Prädiktoren für postpartale psychische Anpassungsprozesse und stellen die Ergebnisse dieser Studie im Rahmen einer Übersichtsarbeit zum internationalen Forschungsstand vor. Die dynamischen neuroplastischen Veränderungen des mütterlichen Gehirns in der Schwangerschaft und im Wochenbett scheinen in enger Verbindung mit peripartal fluktuierenden Hormonspiegeln zu stehen und diese könnten gemeinsam die Entwicklung postpartaler Stimmungsphänomene beeinflussen. Zu den relevanten Einflussgrößen der PPD gehören hormonelle Risikofaktoren, wie der Babyblues und das prämenstruelle Syndrom. Die Kombination beider Faktoren ermöglicht es, das individuelle PPD-Risiko mit einer Sensitivität von 83 % in der ersten Woche postpartum vorherzusagen. Eine anschließende digitale Überwachung der Symptomentwicklung in den ersten 6 Wochen postpartal erlaubte eine präzise Identifikation von Frauen mit PPD. Das Verständnis der Interaktion von hormonellen Schwankungen, Neuroplastizität und psychiatrischen Störungen bietet einen wichtigen Ansatzpunkt für zukünftige Forschungen. Die frühzeitige Identifikation und Diagnose der PPD sowie kritischer Risikofaktoren lassen sich leicht in die klinische Routine und den Alltag der Patientinnen integrieren, wodurch Frauen mit hohem Risiko für eine gezielte Überwachung identifiziert werden können.
Identifiants
pubmed: 39186106
doi: 10.1007/s00115-024-01726-1
pii: 10.1007/s00115-024-01726-1
doi:
Types de publication
English Abstract
Journal Article
Review
Langues
ger
Sous-ensembles de citation
IM
Informations de copyright
© 2024. The Author(s).
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