Management and outcome of cutaneous diphtheria in adolescent refugees in Germany, June 2022 - October 2023.

Balkan route Cutaneous diphtheria Diphtheria Minor refugee Throat diphtheria Toxigenic C. diphtheriae

Journal

Infection
ISSN: 1439-0973
Titre abrégé: Infection
Pays: Germany
ID NLM: 0365307

Informations de publication

Date de publication:
27 Aug 2024
Historique:
received: 27 06 2024
accepted: 11 08 2024
medline: 27 8 2024
pubmed: 27 8 2024
entrez: 27 8 2024
Statut: aheadofprint

Résumé

From September 2022 an increase in Corynebacterium diphtheriae (C. diphtheriae) infections was reported in Europe. Our study focuses on 31 adolescent and young adult refugees with cutaneous C. diphtheriae infections detected in Germany. We examined treatment regimens and outcomes to provide targeted insights into the management of this infection. We distributed a standardized survey, focused on children and adolescents presenting to paediatric clinics through the German Paediatric Infectious Diseases Society (DGPI) and additional professional contacts in Germany. Data were extracted from routine medical documentation and reported anonymously. A total of 31 individuals with cutaneous C. diphtheriae infection were reported by 9 centres. Two of these showed diphtheria toxin (DT) related systemic symptoms and four exhibited systemic inflammation requiring complex management. The remaining 25 cases, with exclusively cutaneous manifestations, were afebrile. Treatment with topical antiseptics and systemic antibiotics, mainly aminopenicillin/beta-lactamase inhibitors (BLI) (35%) or clindamycin (25%), achieved eradication in all but two cases treated with aminopenicillin/BLI. Treatment duration varied between 5 and 17 days. In refugees presenting with chronic skin wounds, C. diphtheriae should be included into the differential diagnosis. Fever seems to be a valuable marker to differentiate severe cases with potentially DT-mediated sequelae from exclusively cutaneous diphtheria (CD). For afebrile CD, topical antiseptics and oral antibiotic therapy with clindamycin for 7 days, followed by clinical surveillance appears to be a safe treatment regimen. Patients with CD who present with fever or pharyngitis should be thoroughly investigated including blood and pharyngeal swab cultures.

Identifiants

pubmed: 39190269
doi: 10.1007/s15010-024-02374-y
pii: 10.1007/s15010-024-02374-y
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. The Author(s).

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Auteurs

Alicia Zink (A)

Division for Paediatric Infectious Diseases and Rheumatology, Department of Paediatrics and Adolescent Medicine, University Medical Centre, Medical Faculty, University of Freiburg, Freiburg, Germany.

Juliana Hofer (J)

Institute for Medical Microbiology and Hygiene, University Medical Centre Freiburg, Freiburg, Germany.

Christian Schneider (C)

Institute for Medical Microbiology and Hygiene, University Medical Centre Freiburg, Freiburg, Germany.

Franziska Kessler (F)

Centre for Child and Adolescent Health, Hegau-Bodensee Clinic Singen, Constance District Health Association, Singen, Germany.

Hannes Klenze (H)

Centre for Child and Adolescent Health, Hegau-Bodensee Clinic Singen, Constance District Health Association, Singen, Germany.

Dietrich Klauwer (D)

Centre for Child and Adolescent Health, Hegau-Bodensee Clinic Singen, Constance District Health Association, Singen, Germany.

Klaudia Maleki (K)

Department of General Medicine and Health Services Research, Heidelberg University Hospital, Interdisciplinary Refugee Outpatient Clinic at the Patrick-Henry-Village State Initial Reception Centre, Heidelberg, Germany.

Andreas Müller (A)

Initial Reception Centre of the State of Hesse, Giessen Regional Council, Giessen, Germany.

Sarah Goretzki (S)

Clinic for Paediatrics I, Essen University Hospital, Essen, Germany.

Shubei Wang (S)

Pediatrics 2: General and Special Pediatrics including Pediatric Infectious Diseases, Klinikum Stuttgart, Olgahospital, Stuttgart, Germany.

Robin Kobbe (R)

Institute for Infection Research and Vaccine Development, University Medical Centre Hamburg- Eppendorf, Hamburg, Germany.
Department of Infection Epidemiology, Bernhard Nocht Institute for Tropical Medicine (BNITM), Hamburg, Germany.

Andrea Vanegas Ramirez (AV)

Bundeswehr Hospital Hamburg, Tropical Dermatology at the Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.

Sebastian Bode (S)

Department of Paediatrics and Adolescent Medicine, Ulm University Medical Centre, Ulm University, Ulm, Germany.

Ales Janda (A)

Department of Paediatrics and Adolescent Medicine, Ulm University Medical Centre, Ulm University, Ulm, Germany.

Roland Fressle (R)

Paediatric and Adolescent Practice Dr Roland Fressle, Freiburg, Germany.

Jonathan Remppis (J)

Department of Neuropaediatrics, General Paediatrics, Diabetology, Endocrinology, Social Paediatrics, University Children's Hospital Tübingen, Tübingen, Germany.
Institute of Tropical Medicine, Travel Medicine and Human Parasitology, University Hospital Tübingen, Tübingen, Germany.

Philipp Henneke (P)

Institute for Infection Prevention and Control, Medical Centre - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Siegbert Rieg (S)

Department of Medicine II, Division of Infectious Diseases, Medical Centre-University of Freiburg, Faculty of Medicine, Freiburg, Germany.

Anja Berger (A)

Consultant Laboratory for Diphtheria, WHO Collaborating Centre for Diphtheria, Bavarian Health and Food Safety Authority, Oberschleissheim, Germany.

Andreas Sing (A)

Consultant Laboratory for Diphtheria, WHO Collaborating Centre for Diphtheria, Bavarian Health and Food Safety Authority, Oberschleissheim, Germany.

Markus Hufnagel (M)

Division for Paediatric Infectious Diseases and Rheumatology, Department of Paediatrics and Adolescent Medicine, University Medical Centre, Medical Faculty, University of Freiburg, Freiburg, Germany.

Benedikt D Spielberger (BD)

Division for Paediatric Infectious Diseases and Rheumatology, Department of Paediatrics and Adolescent Medicine, University Medical Centre, Medical Faculty, University of Freiburg, Freiburg, Germany. benedikt.spielberger@uniklinik-freiburg.de.
Department of Paediatrics and Adolescent Medicine, University Medical Centre, Medical Faculty, University of Freiburg, Mathildenstr. 1, 79106, Freiburg, Germany. benedikt.spielberger@uniklinik-freiburg.de.

Classifications MeSH