High-Resolution Drift Tube Ion Mobility Spectrometer with Ultra-Fast Polarity Switching.

Besides safety and security applications, ion mobility spectrometry (IMS) is increasingly used in other fields such as medicine, environmental monitoring and food quality analysis. However, some applications require gas chromatographic separation before analysis by IMS. Furthermore, different compounds in the sample may form positive or negative ions during ionization and therefore simultaneous detection of both ion polarities is highly beneficial to avoid two chromatographic runs of the same sample. This can be achieved by ultra-fast polarity switching of a single drift tube IMS, allowing for quasi-simultaneous detection of both ion polarities. By using a ramped aperture voltage during the switching process, we overcome the issue of excessive displacement currents at the detector during polarity switching, which usually lead to overdriving the output signal of the high-gain transimpedance amplifier. Furthermore, mechanical aperture grid oscillations caused by polarity switching were also reduced through the ramped aperture voltage. This enables a polarity switching time of only 7 ms at a drift voltage of 8 kV and a drift length of 103 mm, leading to a high resolving power of