miR-29 is an important driver of aging-related phenotypes.
Journal
Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179
Informations de publication
Date de publication:
27 Aug 2024
27 Aug 2024
Historique:
received:
27
02
2023
accepted:
14
08
2024
medline:
28
8
2024
pubmed:
28
8
2024
entrez:
27
8
2024
Statut:
epublish
Résumé
Aging is a consequence of complex molecular changes, but whether a single microRNA (miRNA) can drive aging remains unclear. A miRNA known to be upregulated during both normal and premature aging is miR-29. We find miR-29 to also be among the top miRNAs predicted to drive aging-related gene expression changes. We show that partial loss of miR-29 extends the lifespan of Zmpste24
Identifiants
pubmed: 39191864
doi: 10.1038/s42003-024-06735-z
pii: 10.1038/s42003-024-06735-z
doi:
Substances chimiques
MicroRNAs
0
MIRN29 microRNA, mouse
0
Zmpste24 protein, mouse
EC 3.4.24.-
Membrane Proteins
0
Metalloendopeptidases
EC 3.4.24.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1055Subventions
Organisme : U.S. Department of Health & Human Services | National Institutes of Health (NIH)
ID : AG082140
Organisme : U.S. Department of Health & Human Services | National Institutes of Health (NIH)
ID : AG055304
Organisme : U.S. Department of Health & Human Services | National Institutes of Health (NIH)
ID : DK105965
Organisme : American Diabetes Association (ADA)
ID : 1-16-ACE-47
Informations de copyright
© 2024. The Author(s).
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