Retinal ganglion cell complex thickness in subjects with diabetes mellitus and uncontrolled hypertension in China.
Humans
Retinal Ganglion Cells
/ pathology
Male
Female
Middle Aged
Tomography, Optical Coherence
/ methods
Hypertension
/ complications
Aged
China
/ epidemiology
Blood Pressure
/ physiology
Nerve Fibers
/ pathology
Cross-Sectional Studies
Diabetic Retinopathy
/ diagnosis
Diabetes Mellitus
/ epidemiology
Rural Population
/ statistics & numerical data
Blood glucose
Diabetes mellitus
Hypertension
Retinal ganglion cells
Journal
BMC ophthalmology
ISSN: 1471-2415
Titre abrégé: BMC Ophthalmol
Pays: England
ID NLM: 100967802
Informations de publication
Date de publication:
27 Aug 2024
27 Aug 2024
Historique:
received:
20
05
2023
accepted:
17
08
2024
medline:
28
8
2024
pubmed:
28
8
2024
entrez:
27
8
2024
Statut:
epublish
Résumé
To assess the interactive relationship between blood pressure status and diabetic mellitus (DM) with ganglion cell complex (GCC) thickness in elderly individuals in rural China. Participants aged 50 years and older in a rural area of Daxing District, Beijing, were recruited in this study from October 2018 to November 2018. All subjects underwent a comprehensive systemic and ocular examination. Blood pressure status was graded as normotension, controlled hypertension and uncontrolled hypertension according to blood pressure measurements and the use of any medication for hypertension treatment. GCC parameters were measured by spectral-domain optical coherence tomography (SD-OCT). Generalized linear models (GLM) adjusted for related potential confounders were used to assess the interaction between DM and blood pressure status. Among 1415 screened subjects (2830 eyes), a total of 1117 eyes were enrolled in the final analysis. GLM analysis showed a significant interactive relationship between DM with uncontrolled hypertension status (β = 3.868, p = 0.011). GCC thickness would decrease 0.255 μm per year as the age increased (β=-0.255, p < 0.001). In a subgroup of 574 subjects with uncontrolled hypertension, DM was associated with an increased average of GCC thickness (β = 1.929, p = 0.022). The present results revealed a significant interactive relationship between blood pressure status and DM. The average GCC thickness increased in individuals with DM combined with uncontrolled hypertension, which should be considered in the measurement of GCC. Further studies are warranted to explore ganglion cells changes as a non-invasive method to detect neuron alterations in individuals with DM and uncontrolled hypertension. The registration number of the present trial in the Chinese Clinical Trial Registry is ChiCTR2000037944.
Identifiants
pubmed: 39192272
doi: 10.1186/s12886-024-03644-x
pii: 10.1186/s12886-024-03644-x
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
379Subventions
Organisme : National Natural Science Foundation of China
ID : 81970797
Organisme : National Natural Science Foundation of China
ID : 81970797
Organisme : National Natural Science Foundation of China
ID : 81970797
Organisme : National Natural Science Foundation of China
ID : 81970797
Organisme : National Natural Science Foundation of China
ID : 81970797
Organisme : National Natural Science Foundation of China
ID : 81970797
Informations de copyright
© 2024. The Author(s).
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