A unilateral increase in the occlusal vertical dimension of growing rats results in mandibular deviation.
cone‐beam computed tomography
increased occlusal vertical dimension
mandibular deviation
mandibular growth
β‐catenin
Journal
Orthodontics & craniofacial research
ISSN: 1601-6343
Titre abrégé: Orthod Craniofac Res
Pays: England
ID NLM: 101144387
Informations de publication
Date de publication:
28 Aug 2024
28 Aug 2024
Historique:
revised:
01
08
2024
received:
16
06
2024
accepted:
16
08
2024
medline:
28
8
2024
pubmed:
28
8
2024
entrez:
28
8
2024
Statut:
aheadofprint
Résumé
The effects of unilateral increased occlusal vertical dimension (iOVD) on bilateral craniofacial, mandibular and alveolar development in growing rats were investigated via cone-beam computed tomography (CBCT). The role of Wnt/β-catenin signalling in this process was examined. Forty-eight female Sprague-Dawley rats were randomly allocated into unilateral iOVD and sham groups. At 2, 4 and 8 weeks, the rats were scanned via CBCT to analyse cranial, maxillary, mandibular and dental morphology. Changes in temporomandibular joint (TMJ) cartilage histology and Wnt/β-catenin signalling were assessed by histochemical and immunohistochemical staining and qRT-PCR. Dorsal cephalograms revealed that the mandible in the iOVD group tilted approximately 4° to the right. Unilateral iOVD had little effect on cranial and maxillary growth but inhibited mandibular growth (mandibular length and ramal height), especially on the deviated side (DS). Moreover, unilateral iOVD increased the length of the lower incisors and decreased the height of the molars on the DS. Unilateral iOVD induced bilateral osteoarthritis-like changes in the bilateral TMJ condylar cartilage and activated Wnt/β-catenin signalling in the condylar cartilage, especially on the contralateral side (CLS). Occlusion with unilateral iOVD induced mandibular deviation, significantly inhibited mandibular growth and produced compensatory changes in the alveolar bone. In the iOVD group, the mandibular body length and ramal height were greater on the CLS than on the DS. Moreover, the greater β-catenin protein expression in the TMJ condylar cartilage on the CLS than on the DS may account for the difference in asymmetrical mandibular development.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : The Fujian Province Natural Science Foundation of China
ID : 2023J01702
Organisme : The Fujian Province Natural Science Foundation of China
ID : 2021J01791
Organisme : The Fujian Provincial Health Technology Project
ID : 2023GGA068
Organisme : The research funding for Fujian Medical Leading Innovation Talents
ID : 2018B035
Organisme : The Education and Research Project for Young and Middle-aged Teachers in Fujian Province
ID : JAT210105
Informations de copyright
© 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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