Three-dimensional stem cell models of mammalian gastrulation.
3D models
embryonic stem cells
gastrulation
gastruloids
organoids
Journal
BioEssays : news and reviews in molecular, cellular and developmental biology
ISSN: 1521-1878
Titre abrégé: Bioessays
Pays: United States
ID NLM: 8510851
Informations de publication
Date de publication:
28 Aug 2024
28 Aug 2024
Historique:
revised:
24
07
2024
received:
27
05
2024
accepted:
06
08
2024
medline:
28
8
2024
pubmed:
28
8
2024
entrez:
28
8
2024
Statut:
aheadofprint
Résumé
Gastrulation is a key milestone in the development of an organism. It is a period of cell proliferation and coordinated cellular rearrangement, that creates an outline of the body plan. Our current understanding of mammalian gastrulation has been improved by embryo culture, but there are still many open questions that are difficult to address because of the intrauterine development of the embryos and the low number of specimens. In the case of humans, there are additional difficulties associated with technical and ethical challenges. Over the last few years, pluripotent stem cell models are being developed that have the potential to become useful tools to understand the mammalian gastrulation. Here we review these models with a special emphasis on gastruloids and provide a survey of the methods to produce them robustly, their uses, relationship to embryos, and their prospects as well as their limitations.
Identifiants
pubmed: 39194406
doi: 10.1002/bies.202400123
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2400123Subventions
Organisme : Maria de Maeztu Programme for Units of Excellence in R&D
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/X000907/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/Y00311X/1
Pays : United Kingdom
Organisme : H2020 European Research Council
Organisme : MiniEmbryoBlueprint
ID : (834580)
Organisme : National Centre for the Replacement Refinement and Reduction of Animals in Research
ID : NC/T002131/1
Organisme : National Centre for the Replacement Refinement and Reduction of Animals in Research
ID : NC/X001938/1
Informations de copyright
© 2024 The Author(s). BioEssays published by Wiley Periodicals LLC.
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