A Pilot Study on Proteomic Predictors of Mortality in Stable COPD.
COPD
hemostasis
immunity
mortality
prognosis
proteomic fingerprint
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
14 Aug 2024
14 Aug 2024
Historique:
received:
12
07
2024
revised:
07
08
2024
accepted:
08
08
2024
medline:
28
8
2024
pubmed:
28
8
2024
entrez:
28
8
2024
Statut:
epublish
Résumé
Chronic Obstructive Pulmonary Disease (COPD) is the third leading cause of global mortality. Despite clinical predictors (age, severity, comorbidities, etc.) being established, proteomics offers comprehensive biological profiling to obtain deeper insights into COPD pathophysiology and survival prognoses. This pilot study aimed to identify proteomic footprints that could be potentially useful in predicting mortality in stable COPD patients. Plasma samples from 40 patients were subjected to both blind (liquid chromatography-mass spectrometry) and hypothesis-driven (multiplex immunoassays) proteomic analyses supported by artificial intelligence (AI) before a 4-year clinical follow-up. Among the 34 patients whose survival status was confirmed (mean age 69 ± 9 years, 29.5% women, FEV
Identifiants
pubmed: 39195241
pii: cells13161351
doi: 10.3390/cells13161351
pii:
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Spanish Ministerio de Economía y Competitividad & the European Union
ID : SAF2014-54371
Organisme : Instituto de Salud Carlos III (ISCIII) & European Union
ID : PI21/00785
Organisme : Instituto de Salud Carlos III (ISCIII) & European Union
ID : M-BAE BA22/00009
Organisme : SEPAR
ID : 2015, 2016 and 2019
Organisme : FUCAP
ID : 2014
Organisme : SOCAP
ID : 2020
Organisme : Menarini Spain
ID : Unrestricted Grant 2015