The Loss of PPARγ Expression and Signaling Is a Key Feature of Cutaneous Actinic Disease and Squamous Cell Carcinoma: Association with Tumor Stromal Inflammation.

PPAR gamma / metabolism Carcinoma, Squamous Cell / pathology Animals Humans Skin Neoplasms / pathology Signal Transduction Keratosis, Actinic / pathology Mice Inflammation / pathology Gene Expression Regulation, Neoplastic Stromal Cells / metabolism
actinic keratoses cutaneous squamous cell carcinoma gene set enrichment analysis inflammation non-melanoma skin cancer peroxisome proliferator-activated receptor transcriptomics tumor suppression

Journal

Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052

Informations de publication

Date de publication:
15 Aug 2024
Historique:
received: 28 06 2024
revised: 02 08 2024
accepted: 12 08 2024
medline: 28 8 2024
pubmed: 28 8 2024
entrez: 28 8 2024
Statut: epublish

Résumé

Given the importance of peroxisome proliferator-activated receptor (PPAR)-gamma in epidermal inflammation and carcinogenesis, we analyzed the transcriptomic changes observed in epidermal PPARγ-deficient mice (

Identifiants

DOI: 10.3390/cells13161356 PMID: 39195246
pubmed: 39195246
pii: cells13161356
doi: 10.3390/cells13161356
pii:
doi:

Substances chimiques

PPAR gamma 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : BLRD VA
ID : I01 BX005816
Pays : United States
Organisme : BLRD VA
ID : I01 BX003762
Pays : United States

Auteurs

Raymond L Konger (RL)

Department of Pathology & Laboratory Medicine, Richard L. Roudebush Veterans Affairs Medical Center, Indianapolis, IN 46202, USA.
Department of Pathology & Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
ORCID: 0000-0002-4923-2406

Xiaoling Xuei (X)

Department of Medical & Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

Ethel Derr-Yellin (E)

Department of Pathology & Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

Fang Fang (F)

Department of Medical & Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

Hongyu Gao (H)

Department of Medical & Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

Yunlong Liu (Y)

Department of Medical & Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
ORCID: 0000-0002-2699-626X

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Récepteurs cytoplasmiques et nucléaires › Récepteur PPAR gamma › The Loss of PPARγ Expression and Signaling Is...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs épithéliales épidermoïdes et glandulaires › Tumeurs épidermoïdes › Carcinome épidermoïde › The Loss of PPARγ Expression and Signaling Is...
questionsmedicales.fr › Eucaryotes › Animaux › The Loss of PPARγ Expression and Signaling Is...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The Loss of PPARγ Expression and Signaling Is...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Tumeurs cutanées › The Loss of PPARγ Expression and Signaling Is...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › The Loss of PPARγ Expression and Signaling Is...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Kératose › Kératose actinique › The Loss of PPARγ Expression and Signaling Is...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › The Loss of PPARγ Expression and Signaling Is...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › The Loss of PPARγ Expression and Signaling Is...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes tumoraux › The Loss of PPARγ Expression and Signaling Is...
questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Cellules stromales › The Loss of PPARγ Expression and Signaling Is...