Non-invasive mapping of systemic neutrophil dynamics upon cardiovascular injury.


Journal

Nature cardiovascular research
ISSN: 2731-0590
Titre abrégé: Nat Cardiovasc Res
Pays: England
ID NLM: 9918284280206676

Informations de publication

Date de publication:
Feb 2023
Historique:
received: 07 09 2021
accepted: 22 12 2022
medline: 1 2 2023
pubmed: 1 2 2023
entrez: 28 8 2024
Statut: ppublish

Résumé

Neutrophils play a complex role during onset of tissue injury and subsequent resolution and healing. To assess neutrophil dynamics upon cardiovascular injury, here we develop a non-invasive, background-free approach for specific mapping of neutrophil dynamics by whole-body magnetic resonance imaging using targeted multimodal fluorine-loaded nanotracers engineered with binding peptides specifically directed against murine or human neutrophils. Intravenous tracer application before injury allowed non-invasive three-dimensional visualization of neutrophils within their different hematopoietic niches over the entire body and subsequent monitoring of their egress into affected tissues. Stimulated murine and human neutrophils exhibited enhanced labeling due to upregulation of their target receptors, which could be exploited as an in vivo readout for their activation state in both sterile and nonsterile cardiovascular inflammation. This non-invasive approach will allow us to identify hidden origins of bacterial or sterile inflammation in patients and also to unravel cardiovascular disease states on the verge of severe aggravation due to enhanced neutrophil infiltration or activation.

Identifiants

pubmed: 39196054
doi: 10.1038/s44161-022-00210-w
pii: 10.1038/s44161-022-00210-w
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

126-143

Subventions

Organisme : Deutsche Forschungsgemeinschaft (German Research Foundation)
ID : INST 208/764-1 FUGG
Organisme : Deutsche Forschungsgemeinschaft (German Research Foundation)
ID : TRR 259, subproject B03

Informations de copyright

© 2023. The Author(s).

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Auteurs

Pascal Bouvain (P)

Experimental Cardiovascular Imaging, Institute for Molecular Cardiology, Heinrich Heine University, Düsseldorf, Germany.

Zhaoping Ding (Z)

Experimental Cardiovascular Imaging, Institute for Molecular Cardiology, Heinrich Heine University, Düsseldorf, Germany.

Shiwa Kadir (S)

Experimental Cardiovascular Imaging, Institute for Molecular Cardiology, Heinrich Heine University, Düsseldorf, Germany.

Patricia Kleimann (P)

Experimental Cardiovascular Imaging, Institute for Molecular Cardiology, Heinrich Heine University, Düsseldorf, Germany.

Nils Kluge (N)

Experimental Cardiovascular Imaging, Institute for Molecular Cardiology, Heinrich Heine University, Düsseldorf, Germany.

Zeynep-Büsra Tiren (ZB)

Experimental Cardiovascular Imaging, Institute for Molecular Cardiology, Heinrich Heine University, Düsseldorf, Germany.

Bodo Steckel (B)

Experimental Cardiovascular Imaging, Institute for Molecular Cardiology, Heinrich Heine University, Düsseldorf, Germany.

Vera Flocke (V)

Experimental Cardiovascular Imaging, Institute for Molecular Cardiology, Heinrich Heine University, Düsseldorf, Germany.

Ria Zalfen (R)

Experimental Cardiovascular Imaging, Institute for Molecular Cardiology, Heinrich Heine University, Düsseldorf, Germany.

Patrick Petzsch (P)

Biological and Medical Research Center (BMFZ), Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.

Thorsten Wachtmeister (T)

Biological and Medical Research Center (BMFZ), Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.

Gordon John (G)

Dental Office/Oral Surgery, Dr. G. John, Plauen, Germany.

Nirojah Subramaniam (N)

Institute for Experimental Immunology and Imaging, Department of Immunodynamics, University Hospital Essen, University Duisburg-Essen, Essen, Germany.

Wolfgang Krämer (W)

Department of Pharmaceutical Technology and Biopharmacy, Albert Ludwig University, Freiburg im Breisgau, Germany.

Tobias Strasdeit (T)

Institute of Neuro- and Sensory Physiology, Heinrich Heine University, Düsseldorf, Germany.

Mehrnaz Mehrabipour (M)

Institute of Biochemistry and Molecular Biology II, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, Germany.

Jens M Moll (JM)

Institute of Biochemistry and Molecular Biology II, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, Germany.

Rolf Schubert (R)

Department of Pharmaceutical Technology and Biopharmacy, Albert Ludwig University, Freiburg im Breisgau, Germany.

Mohammad Reza Ahmadian (MR)

Institute of Biochemistry and Molecular Biology II, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, Germany.

Florian Bönner (F)

Department of Cardiology, Pneumology and Angiology, University Hospital Düsseldorf, Düsseldorf, Germany.

Udo Boeken (U)

Clinic for Cardiac Surgery, University Hospital Düsseldorf, Düsseldorf, Germany.

Ralf Westenfeld (R)

Department of Cardiology, Pneumology and Angiology, University Hospital Düsseldorf, Düsseldorf, Germany.

Daniel Robert Engel (DR)

Institute for Experimental Immunology and Imaging, Department of Immunodynamics, University Hospital Essen, University Duisburg-Essen, Essen, Germany.

Malte Kelm (M)

Department of Cardiology, Pneumology and Angiology, University Hospital Düsseldorf, Düsseldorf, Germany.
Cardiovascular Research Institute Düsseldorf (CARID), Heinrich Heine University, Düsseldorf, Germany.

Jürgen Schrader (J)

Experimental Cardiovascular Imaging, Institute for Molecular Cardiology, Heinrich Heine University, Düsseldorf, Germany.
Cardiovascular Research Institute Düsseldorf (CARID), Heinrich Heine University, Düsseldorf, Germany.

Karl Köhrer (K)

Biological and Medical Research Center (BMFZ), Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.

Maria Grandoch (M)

Institute for Translational Pharmacology, Heinrich Heine University, Düsseldorf, Germany.

Sebastian Temme (S)

Experimental Cardiovascular Imaging, Institute for Molecular Cardiology, Heinrich Heine University, Düsseldorf, Germany.
Department of Anesthesiology, University Hospital Düsseldorf, Düsseldorf, Germany.

Ulrich Flögel (U)

Experimental Cardiovascular Imaging, Institute for Molecular Cardiology, Heinrich Heine University, Düsseldorf, Germany. floegel@uni-duesseldorf.de.
Department of Cardiology, Pneumology and Angiology, University Hospital Düsseldorf, Düsseldorf, Germany. floegel@uni-duesseldorf.de.
Cardiovascular Research Institute Düsseldorf (CARID), Heinrich Heine University, Düsseldorf, Germany. floegel@uni-duesseldorf.de.

Classifications MeSH