Phase I Clinical Evaluation of Designed Ankyrin Repeat Protein [

[99mTc]Tc(CO)3-(HE)3-Ec1 lung cancer single-photon emission computed tomography

Journal

Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829

Informations de publication

Date de publication:
10 Aug 2024
Historique:
received: 05 07 2024
revised: 06 08 2024
accepted: 09 08 2024
medline: 31 8 2024
pubmed: 31 8 2024
entrez: 29 8 2024
Statut: epublish

Résumé

A high level of EpCAM overexpression in lung cancer makes this protein a promising target for targeted therapy. Radionuclide visualization of EpCAM expression would facilitate the selection of patients potentially benefiting from such treatment. Single-photon computed tomography (SPECT) using

Identifiants

DOI: 10.3390/cancers16162815 PMID: 39199590
pubmed: 39199590
pii: cancers16162815
doi: 10.3390/cancers16162815
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Ministry of Science and Higher Education of the Russian Federation
ID : 075-15-2024-536

Auteurs

Roman Zelchan (R)

Department of Nuclear Medicine, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, 634055 Tomsk, Russia.
Research Centrum for Oncotheranostics, Research School of Chemistry and Applied Biomedical Sciences, Tomsk Polytechnic University, 634050 Tomsk, Russia.

Vladimir Chernov (V)

Department of Nuclear Medicine, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, 634055 Tomsk, Russia.
Research Centrum for Oncotheranostics, Research School of Chemistry and Applied Biomedical Sciences, Tomsk Polytechnic University, 634050 Tomsk, Russia.

Anna Medvedeva (A)

Department of Nuclear Medicine, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, 634055 Tomsk, Russia.
Research Centrum for Oncotheranostics, Research School of Chemistry and Applied Biomedical Sciences, Tomsk Polytechnic University, 634050 Tomsk, Russia.

Anastasia Rybina (A)

Department of Nuclear Medicine, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, 634055 Tomsk, Russia.
Research Centrum for Oncotheranostics, Research School of Chemistry and Applied Biomedical Sciences, Tomsk Polytechnic University, 634050 Tomsk, Russia.

Olga Bragina (O)

Department of Nuclear Medicine, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, 634055 Tomsk, Russia.
Research Centrum for Oncotheranostics, Research School of Chemistry and Applied Biomedical Sciences, Tomsk Polytechnic University, 634050 Tomsk, Russia.

Elizaveta Mishina (E)

Department of Nuclear Medicine, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, 634055 Tomsk, Russia.

Mariia Larkina (M)

Research Centrum for Oncotheranostics, Research School of Chemistry and Applied Biomedical Sciences, Tomsk Polytechnic University, 634050 Tomsk, Russia.
Department of Pharmaceutical Analysis, Siberian State Medical University, 634050 Tomsk, Russia.
ORCID: 0000-0003-1176-2441

Ruslan Varvashenya (R)

Research Centrum for Oncotheranostics, Research School of Chemistry and Applied Biomedical Sciences, Tomsk Polytechnic University, 634050 Tomsk, Russia.
Department of Pharmaceutical Analysis, Siberian State Medical University, 634050 Tomsk, Russia.

Anastasia Fominykh (A)

Research Centrum for Oncotheranostics, Research School of Chemistry and Applied Biomedical Sciences, Tomsk Polytechnic University, 634050 Tomsk, Russia.

Alexey Schulga (A)

Research Centrum for Oncotheranostics, Research School of Chemistry and Applied Biomedical Sciences, Tomsk Polytechnic University, 634050 Tomsk, Russia.
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 117997 Moscow, Russia.
ORCID: 0000-0003-3425-0828

Elena Konovalova (E)

Research Centrum for Oncotheranostics, Research School of Chemistry and Applied Biomedical Sciences, Tomsk Polytechnic University, 634050 Tomsk, Russia.
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 117997 Moscow, Russia.

Anzhelika Vorobyeva (A)

Department of Immunology, Genetics and Pathology, Uppsala University, 75185 Uppsala, Sweden.
ORCID: 0000-0002-4778-3909

Anna Orlova (A)

Department of Medicinal Chemistry, Uppsala University, 75185 Uppsala, Sweden.
ORCID: 0000-0001-6120-2683

Liubov Tashireva (L)

Laboratory of Molecular Therapy of Cancer, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, 634055 Tomsk, Russia.
ORCID: 0000-0003-2061-8417

Sergey M Deyev (SM)

Research Centrum for Oncotheranostics, Research School of Chemistry and Applied Biomedical Sciences, Tomsk Polytechnic University, 634050 Tomsk, Russia.
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 117997 Moscow, Russia.
ORCID: 0000-0002-3952-0631

Vladimir Tolmachev (V)

Department of Immunology, Genetics and Pathology, Uppsala University, 75185 Uppsala, Sweden.
ORCID: 0000-0002-6122-1734

Classifications MeSH