Efficacy and Safety of Oral Neomycin for the Decolonization of Carbapenem-Resistant
CRE
carbapenem-resistant Enterobacterales
colonization
decolonization
neomycin
Journal
Antibiotics (Basel, Switzerland)
ISSN: 2079-6382
Titre abrégé: Antibiotics (Basel)
Pays: Switzerland
ID NLM: 101637404
Informations de publication
Date de publication:
20 Aug 2024
20 Aug 2024
Historique:
received:
02
07
2024
revised:
01
08
2024
accepted:
05
08
2024
medline:
31
8
2024
pubmed:
31
8
2024
entrez:
29
8
2024
Statut:
epublish
Résumé
Patients with carbapenem-resistant In this open-label randomized controlled trial, stool/rectal swab samples from high-risk patients were collected and tested for CRE colonization in the GI tract. Patients who had CRE and met eligible criteria were divided into a neomycin group ( The two groups' baseline characteristics were similar. CRE presence on day 7 ± 2 was significantly lower in the neomycin group (46.2%) than in the control group (80.8%, Neomycin effectively reduced CRE colonization on day 7 ± 2, but its impact waned by day 14 ± 2. This suggests that neomycin dosage was too low and the duration of treatment was too short for lasting CRE decolonization.
Sections du résumé
BACKGROUND
BACKGROUND
Patients with carbapenem-resistant
METHODS
METHODS
In this open-label randomized controlled trial, stool/rectal swab samples from high-risk patients were collected and tested for CRE colonization in the GI tract. Patients who had CRE and met eligible criteria were divided into a neomycin group (
RESULTS
RESULTS
The two groups' baseline characteristics were similar. CRE presence on day 7 ± 2 was significantly lower in the neomycin group (46.2%) than in the control group (80.8%,
CONCLUSIONS
CONCLUSIONS
Neomycin effectively reduced CRE colonization on day 7 ± 2, but its impact waned by day 14 ± 2. This suggests that neomycin dosage was too low and the duration of treatment was too short for lasting CRE decolonization.
Identifiants
pubmed: 39200081
pii: antibiotics13080781
doi: 10.3390/antibiotics13080781
pii:
doi:
Types de publication
Journal Article
Langues
eng