Molecular Hydrogen and Extracorporeal Gas Exchange: A Match Made in Heaven? An In Vitro Pilot Study.

ECMO anti-inflammatory action extracorporeal circulation inflammation molecular hydrogen oxidative stress

Journal

Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304

Informations de publication

Date de publication:
18 Aug 2024
Historique:
received: 01 06 2024
revised: 28 07 2024
accepted: 15 08 2024
medline: 31 8 2024
pubmed: 31 8 2024
entrez: 29 8 2024
Statut: epublish

Résumé

Extracorporeal circulation (ECC) is frequently implemented in a vast array of modalities such as hemodialysis, cardiopulmonary bypass, extracorporeal membrane oxygenation (ECMO), and others. Patients receiving any such therapy are frequently encumbered with chronic inflammation, which is inherently accompanied by oxidative stress. However, ECC treatments themselves are also responsible for sustaining or promoting inflammation. On these grounds, an in vitro study was designed to investigate the therapeutic potential of molecular hydrogen (H

Identifiants

pubmed: 39200347
pii: biomedicines12081883
doi: 10.3390/biomedicines12081883
pii:
doi:

Types de publication

Journal Article

Langues

eng

Auteurs

Foivos Leonidas Mouzakis (FL)

ECC Lab, Institute of Physiology, Medical Faculty, RWTH Aachen University, 52074 Aachen, Germany.

Flutura Hima (F)

Department of Thoracic Surgery, Medical Faculty, RWTH Aachen University, 52074 Aachen, Germany.

Ali Kashefi (A)

ECC Lab, Institute of Physiology, Medical Faculty, RWTH Aachen University, 52074 Aachen, Germany.

Johannes Greven (J)

Department of Thoracic Surgery, Medical Faculty, RWTH Aachen University, 52074 Aachen, Germany.

Lothar Rink (L)

Institute of Immunology, Medical Faculty, RWTH Aachen University, 52074 Aachen, Germany.

Emiel P C van der Vorst (EPC)

Institute for Molecular Cardiovascular Research, Medical Faculty, RWTH Aachen University, 52074 Aachen, Germany.
Aachen-Maastricht Institute for CardioRenal Disease (AMICARE), RWTH Aachen University, 52074 Aachen, Germany.
Interdisciplinary Center for Clinical Research (IZKF), RWTH Aachen University, 52074 Aachen, Germany.
Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität, 80336 München, Germany.

Joachim Jankowski (J)

Institute for Molecular Cardiovascular Research, Medical Faculty, RWTH Aachen University, 52074 Aachen, Germany.
Aachen-Maastricht Institute for CardioRenal Disease (AMICARE), RWTH Aachen University, 52074 Aachen, Germany.
Department of Pathology, Cardiovascular Research Institute Maastricht (CARIM), University of Maastricht, 6200 MD Maastricht, The Netherlands.

Khosrow Mottaghy (K)

ECC Lab, Institute of Physiology, Medical Faculty, RWTH Aachen University, 52074 Aachen, Germany.

Jan Spillner (J)

Department of Thoracic Surgery, Medical Faculty, RWTH Aachen University, 52074 Aachen, Germany.

Classifications MeSH