Effects of Curcumin and Estrogen Receptor Alpha in Luminal Breast Cancer Cells.
17ß-estradiol
antiestrogens
breast cancer
cancer therapy
curcumin
estrogen receptor alpha
estrogens
Journal
Diagnostics (Basel, Switzerland)
ISSN: 2075-4418
Titre abrégé: Diagnostics (Basel)
Pays: Switzerland
ID NLM: 101658402
Informations de publication
Date de publication:
16 Aug 2024
16 Aug 2024
Historique:
received:
12
06
2024
revised:
26
07
2024
accepted:
05
08
2024
medline:
31
8
2024
pubmed:
31
8
2024
entrez:
29
8
2024
Statut:
epublish
Résumé
This work examined the potential benefit of curcumin in breast cancer patients as a supplementary drug in ER-positive cancers. The results indicated that in the MCF-7 human breast cancer cell line, E2 and curcumin decreased cell proliferation and the colony-forming capacity and down-regulated protein expression as well as important molecules associated with cell proliferation, such as PCNA and estrogen receptor alpha; genes associated with the epithelial-mesenchymal transition, such as β-catenin, Vimentin, and E-cadherin; and molecules associated with apoptosis. Clinical studies in bioinformatics have indicated a positive correlation between
Identifiants
pubmed: 39202273
pii: diagnostics14161785
doi: 10.3390/diagnostics14161785
pmc: PMC11353822
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Fondo Nacional de Desarrollo Científico y Tecnológico (FONDECYT/ANID)
ID : FONDECYT 1231537 (G.M.C)
Organisme : Fondo Nacional de Desarrollo Científico y Tecnológico (FONDECYT/ANID)
ID : FONDECYT 1200656 (G.M.C)
Organisme : Fondo Nacional de Desarrollo Científico y Tecnológico (FONDECYT/ANID)
ID : Postdoctoral Grant 3190744 (J.P.M)
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