Perivascular Fat: A Novel Risk Factor for Coronary Artery Disease.
atherosclerosis
cardiovascular disease
coronary computed tomography angiography
fat attenuation index
pericoronary adipose tissue attenuation
perivascular adipose tissue
Journal
Diagnostics (Basel, Switzerland)
ISSN: 2075-4418
Titre abrégé: Diagnostics (Basel)
Pays: Switzerland
ID NLM: 101658402
Informations de publication
Date de publication:
22 Aug 2024
22 Aug 2024
Historique:
received:
02
07
2024
revised:
17
08
2024
accepted:
20
08
2024
medline:
31
8
2024
pubmed:
31
8
2024
entrez:
29
8
2024
Statut:
epublish
Résumé
Perivascular adipose tissue (PVAT) interacts with the vascular wall and secretes bioactive factors which regulate vascular wall physiology. Vice versa, vascular wall inflammation affects the adjacent PVAT via paracrine signals, which induce cachexia-type morphological changes in perivascular fat. These changes can be quantified in pericoronary adipose tissue (PCAT), as an increase in PCAT attenuation in coronary computed tomography angiography images. Fat attenuation index (FAI), a novel imaging biomarker, measures PCAT attenuation around coronary artery segments and is associated with coronary artery disease presence, progression, and plaque instability. Beyond its diagnostic capacity, PCAT attenuation can also ameliorate cardiac risk stratification, thus representing an innovative prognostic biomarker of cardiovascular disease (CVD). However, technical, biological, and anatomical factors are weakly related to PCAT attenuation and cause variation in its measurement. Thus, to integrate FAI, a research tool, into clinical practice, a medical device has been designed to provide FAI values standardized for these factors. In this review, we discuss the interplay of PVAT with the vascular wall, the diagnostic and prognostic value of PCAT attenuation, and its integration as a CVD risk marker in clinical practice.
Identifiants
pubmed: 39202318
pii: diagnostics14161830
doi: 10.3390/diagnostics14161830
pmc: PMC11353828
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
Front Cardiovasc Med. 2022 Apr 26;9:822308
pubmed: 35557525
J Cardiovasc Comput Tomogr. 2021 Sep-Oct;15(5):455-456
pubmed: 33952437
Eur Heart J. 2023 Oct 12;44(38):3827-3844
pubmed: 37599464
Br J Pharmacol. 2014 Feb;171(3):595-617
pubmed: 24490856
Biochem Biophys Res Commun. 2004 Apr 9;316(3):924-9
pubmed: 15033490
J Cardiovasc Comput Tomogr. 2020 Nov - Dec;14(6):483-489
pubmed: 32057707
Curr Top Med Chem. 2023;23(22):2158-2171
pubmed: 37138428
N Engl J Med. 2022 Feb 24;386(8):768-779
pubmed: 35196429
Eur Heart J Cardiovasc Imaging. 2020 Jun 1;21(6):599-605
pubmed: 32091086
Eur Heart J. 2021 Sep 7;42(34):3227-3337
pubmed: 34458905
Circulation. 2013 Jun 4;127(22):2209-21
pubmed: 23625959
Cardiovasc Diabetol. 2022 Mar 18;21(1):44
pubmed: 35303857
Eur Radiol. 2010 Dec;20(12):2824-33
pubmed: 20640900
Circ Cardiovasc Imaging. 2023 Feb;16(2):e014672
pubmed: 36802444
Hellenic J Cardiol. 2022 Sep-Oct;67:73-75
pubmed: 35842080
Hellenic J Cardiol. 2019 Sep - Oct;60(5):294-295
pubmed: 31846701
Eur Radiol. 2020 Feb;30(2):673-681
pubmed: 31444596
JACC Cardiovasc Imaging. 2021 Aug;14(8):1598-1610
pubmed: 33958312
Hellenic J Cardiol. 2023 Oct 31;:
pubmed: 37913991
Circulation. 2009 Mar 31;119(12):1586-91
pubmed: 19289634
Hellenic J Cardiol. 2023 May-Jun;71:42-54
pubmed: 36646212
J Am Coll Cardiol. 2018 Jun 12;71(23):2708-2709
pubmed: 29880135
Atherosclerosis. 2018 Sep;276:182-188
pubmed: 29866393
J Immunol. 2005 May 1;174(9):5789-95
pubmed: 15843582
Circ Cardiovasc Imaging. 2010 Mar;3(2):142-8
pubmed: 20061516
N Engl J Med. 2018 Sep 06;379(10):924-933
pubmed: 30145934
J Am Coll Cardiol. 2023 Mar 7;81(9):913-923
pubmed: 36858711
Cardiovasc Res. 2016 Feb 1;109(2):228-39
pubmed: 26645979
Eur Heart J. 2023 Feb 7;44(6):437-439
pubmed: 36592110
Lancet. 2018 Sep 15;392(10151):929-939
pubmed: 30170852
Int J Cardiol. 2020 Nov 15;319:144-149
pubmed: 32553595
Cardiovasc Diabetol. 2024 Mar 29;23(1):108
pubmed: 38553738
Am J Cardiol. 2019 Feb 1;123(3):523-531
pubmed: 30477802
Arterioscler Thromb Vasc Biol. 2020 Nov;40(11):2569-2576
pubmed: 32878476
JAMA Cardiol. 2019 Sep 1;4(9):885-891
pubmed: 31365032
Atherosclerosis. 2016 Jan;244:38-43
pubmed: 26590865
Br J Pharmacol. 2017 Oct;174(20):3411-3424
pubmed: 27976387
Lancet. 2024 Jun 15;403(10444):2606-2618
pubmed: 38823406
Eur Heart J Cardiovasc Imaging. 2014 Aug;15(8):863-9
pubmed: 24497517
JACC Cardiovasc Imaging. 2022 Mar;15(3):460-471
pubmed: 34801448
Circ Cardiovasc Imaging. 2023 Feb;16(2):e015135
pubmed: 36734240
Angiology. 2023 Jan;74(1):22-30
pubmed: 36214765
Eur Heart J Cardiovasc Imaging. 2019 Jun 1;20(6):636-643
pubmed: 30789223
J Am Coll Cardiol. 2020 Aug 11;76(6):755-757
pubmed: 32762910
Nat Rev Cardiol. 2019 Feb;16(2):83-99
pubmed: 30287946
J Physiol. 2017 Jun 15;595(12):3907-3917
pubmed: 28191635
J Atheroscler Thromb. 2023 Apr 1;30(4):364-376
pubmed: 35753780
JACC Cardiovasc Imaging. 2020 Nov;13(11):2371-2383
pubmed: 32861654
Circ Res. 2016 Mar 4;118(5):842-55
pubmed: 26838789
J Comput Assist Tomogr. 2017 Sep/Oct;41(5):762-767
pubmed: 28914752
Vascul Pharmacol. 2022 Apr;143:106968
pubmed: 35123060
Eur Heart J. 2021 Jan 1;42(1):113-131
pubmed: 32176778
Am J Physiol Heart Circ Physiol. 2010 Jul;299(1):H193-201
pubmed: 20435848
Front Med (Lausanne). 2020 Nov 05;7:546445
pubmed: 33251225
Eur Heart J. 2020 Feb 1;41(6):748-758
pubmed: 31317172
Free Radic Biol Med. 2020 Jan;146:264-274
pubmed: 31698080
Eur J Prev Cardiol. 2022 Mar 30;29(4):608-624
pubmed: 33930129
Cardiovasc Res. 2017 Jul 1;113(9):1009-1023
pubmed: 28838042
JAMA Cardiol. 2018 Sep 1;3(9):858-863
pubmed: 30027285
Cardiovasc Res. 2017 Jul 1;113(9):1074-1086
pubmed: 28549096
Hellenic J Cardiol. 2019 May - Jun;60(3):149-151
pubmed: 31520726
JACC Cardiovasc Imaging. 2017 May;10(5):582-593
pubmed: 28473100
Cardiovasc Res. 2024 May 29;120(7):678-680
pubmed: 38523341
J Am Coll Cardiol. 2018 May 22;71(20):2360-2372
pubmed: 29773163
Antioxidants (Basel). 2021 Nov 04;10(11):
pubmed: 34829629
Eur J Nucl Med Mol Imaging. 2021 Jun;48(6):1806-1812
pubmed: 33200300
J Biol Chem. 2003 Nov 7;278(45):45021-6
pubmed: 12944390
Lancet. 2005 May 21-27;365(9473):1817-20
pubmed: 15910955
Eur J Nucl Med Mol Imaging. 2021 Jun;48(6):1707-1708
pubmed: 33398410
Tomography. 2022 Jul 06;8(4):1742-1758
pubmed: 35894012
Eur Heart J. 2015 Apr 1;36(13):795-805a
pubmed: 23525094
Cardiovasc Res. 2021 Nov 22;117(13):2677-2690
pubmed: 34450625
Eur J Heart Fail. 2018 Nov;20(11):1559-1566
pubmed: 30070041
Curr Cardiol Rep. 2023 Nov;25(11):1623-1632
pubmed: 37897677
Eur Heart J Cardiovasc Imaging. 2022 Nov 17;23(12):e526-e536
pubmed: 36069510
Free Radic Biol Med. 2021 Jan;162:233-242
pubmed: 33099000
Sci Transl Med. 2017 Jul 12;9(398):
pubmed: 28701474
JACC Cardiovasc Imaging. 2019 Oct;12(10):2000-2010
pubmed: 30772226
Curr Probl Cardiol. 2023 Oct;48(10):101841
pubmed: 37244513
Circulation. 2000 Sep 12;102(11):1296-301
pubmed: 10982546
Eur Heart J. 2019 Nov 14;40(43):3529-3543
pubmed: 31504423