Pediatric Hemispheric High-Grade Gliomas and H3.3-G34 Mutation: A Review of the Literature on Biological Features and New Therapeutic Strategies.

Humans Glioma / genetics Mutation Brain Neoplasms / genetics Histones / genetics Child Epigenesis, Genetic Tumor Microenvironment / genetics
glioma high-grade histone mutation immunotherapy pediatric targeted therapy

Journal

Genes
ISSN: 2073-4425
Titre abrégé: Genes (Basel)
Pays: Switzerland
ID NLM: 101551097

Informations de publication

Date de publication:
06 Aug 2024
Historique:
received: 20 06 2024
revised: 25 07 2024
accepted: 02 08 2024
medline: 1 9 2024
pubmed: 31 8 2024
entrez: 29 8 2024
Statut: epublish

Résumé

Pediatric high-grade glioma (pHGG) encompasses a wide range of gliomas with different genomic, epigenomic, and transcriptomic features. Almost 50% of pHGGs present a mutation in genes coding for histone 3, including the subtype harboring the H3.3-G34 mutation. In this context, histone mutations are frequently associated with mutations in

Identifiants

DOI: 10.3390/genes15081038 PMID: 39202398
pubmed: 39202398
pii: genes15081038
doi: 10.3390/genes15081038
pii:
doi:

Substances chimiques

Histones 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Marta Bonada (M)

Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133 Milan, Italy.
Department of Oncology and Hemato-Oncology, University of Milan School of Medicine, Via Rudini 8, 20122 Milan, Italy.

Matilde Pittarello (M)

Department of Biomedical Sciences, Humanitas University, 20072 Milan, Italy.
ORCID: 0009-0001-7927-0825

Emerson De Fazio (E)

Department of Medicine, Vita-Salute San Raffaele University School of Medicine, 20132 Milan, Italy.

Alessandro Gans (A)

Department of Oncology and Hemato-Oncology, University of Milan School of Medicine, Via Rudini 8, 20122 Milan, Italy.
ASST Ovest Milanese, Neurology and Stroke Unit, Neuroscience Department, 20025 Legnano, Italy.
ORCID: 0000-0002-6222-8479

Paolo Alimonti (P)

Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02120, USA.

Hasan Slika (H)

Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
ORCID: 0000-0003-4597-3642

Federico Legnani (F)

Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133 Milan, Italy.
Department of Oncology and Hemato-Oncology, University of Milan School of Medicine, Via Rudini 8, 20122 Milan, Italy.
ORCID: 0000-0002-3547-1510

Francesco Di Meco (F)

Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133 Milan, Italy.
Department of Oncology and Hemato-Oncology, University of Milan School of Medicine, Via Rudini 8, 20122 Milan, Italy.
Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
ORCID: 0000-0001-6213-5793

Betty Tyler (B)

Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
ORCID: 0000-0001-9800-6969

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Pediatric Hemispheric High-Grade Gliomas and...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu nerveux › Tumeurs neuroectodermiques › Tumeurs neuroépitheliales › Gliome › Pediatric Hemispheric High-Grade Gliomas and...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Pediatric Hemispheric High-Grade Gliomas and...
questionsmedicales.fr › Maladies du système nerveux › Tumeurs du système nerveux › Tumeurs du système nerveux central › Tumeurs du cerveau › Pediatric Hemispheric High-Grade Gliomas and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Histone › Pediatric Hemispheric High-Grade Gliomas and...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Pediatric Hemispheric High-Grade Gliomas and...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Pediatric Hemispheric High-Grade Gliomas and...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Microenvironnement tumoral › Pediatric Hemispheric High-Grade Gliomas and...