Niacinamide Antimicrobial Efficacy and Its Mode of Action via Microbial Cell Cycle Arrest.
DNA damage
DNA interaction
antimicrobial efficacy
cell-cycle arrest
cosmetic application
niacinamide
preservation
skincare
Journal
Microorganisms
ISSN: 2076-2607
Titre abrégé: Microorganisms
Pays: Switzerland
ID NLM: 101625893
Informations de publication
Date de publication:
02 Aug 2024
02 Aug 2024
Historique:
received:
08
07
2024
revised:
24
07
2024
accepted:
01
08
2024
medline:
31
8
2024
pubmed:
31
8
2024
entrez:
29
8
2024
Statut:
epublish
Résumé
Niacinamide is a versatile compound widely used in the personal care industry for its ample skin benefits. As a precursor to nicotinamide adenine dinucleotide (NAD+), essential for ATP production and a substrate for poly-ADP-ribose polymerase-1 (PARP-1), studies have highlighted its roles in DNA repair, cellular stress mechanisms, and anti-aging benefits. Niacinamide was also studied for its antimicrobial activity, particularly in the context of host-infection via host immune response, yet its direct antimicrobial activity and the mechanisms of action remain unclear. Its multifunctionality makes it an appealing bioactive molecule for skincare products as well as a potential preservative solution. This study explores niacinamide's antimicrobial mode of action against four common cosmetic pathogens. Our findings indicate that niacinamide is causing microbial cell cycle arrest; while cells were found to increase their volume and length under treatment to prepare for cell division, complete separation into two daughter cells was prevented. Fluorescence microscopy revealed expanded chromatin, alongside a decreased RNA expression of the DNA-binding protein gene,
Identifiants
pubmed: 39203423
pii: microorganisms12081581
doi: 10.3390/microorganisms12081581
pmc: PMC11356291
pii:
doi:
Types de publication
Journal Article
Langues
eng
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