Anti-RBD Antibody Levels and IFN-γ-Specific T Cell Response Are Associated with a More Rapid Swab Reversion in Patients with Multiple Sclerosis after the Booster Dose of COVID-19 Vaccination.
COVID-19 vaccination
SARS-CoV-2
T cell response
antibody response
breakthrough infection
disease-modifying therapies
multiple sclerosis
Journal
Vaccines
ISSN: 2076-393X
Titre abrégé: Vaccines (Basel)
Pays: Switzerland
ID NLM: 101629355
Informations de publication
Date de publication:
19 Aug 2024
19 Aug 2024
Historique:
received:
08
07
2024
revised:
02
08
2024
accepted:
13
08
2024
medline:
31
8
2024
pubmed:
31
8
2024
entrez:
29
8
2024
Statut:
epublish
Résumé
This study investigated the incidence and severity of SARS-CoV-2 breakthrough infections (BIs) and the time to swab reversion in patients with multiple sclerosis (PwMS) after the booster dose of COVID-19 mRNA vaccines. We enrolled 64 PwMS who had completed the three-dose mRNA vaccine schedule and had never experienced COVID-19 before. Among the 64 PwMS, 43.8% had BIs with a median time since the third vaccine dose of 155 days. BIs occurred more frequently in ocrelizumab-treated patients (64.7%). Patients with a relapsing-remitting MS course showed a reduced incidence of BIs compared with those with a primary-progressive disease (
Identifiants
pubmed: 39204049
pii: vaccines12080926
doi: 10.3390/vaccines12080926
pmc: PMC11359508
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Ministero della Salute
ID : Ricerca Corrente on emerging infections
Organisme : Camera di Commercio, Industria e Artigianato di Roma
ID : resolution number 395 on May 25, 2021
Références
JCI Insight. 2022 Feb 22;7(4):
pubmed: 35030101
Nature. 2022 Feb;602(7898):657-663
pubmed: 35016194
Nature. 2022 Mar;603(7902):700-705
pubmed: 35104835
Pathogens. 2023 Jun 22;12(7):
pubmed: 37513709
Neurol Sci. 2022 Dec;43(12):6657-6659
pubmed: 35962215
Front Neurol. 2022 May 31;13:881988
pubmed: 35711277
J Neurol Neurosurg Psychiatry. 2023 Apr;94(4):290-299
pubmed: 36522154
Science. 2020 Aug 28;369(6507):1119-1123
pubmed: 32661058
Behav Res Methods. 2009 Nov;41(4):1149-60
pubmed: 19897823
Clin Chem Lab Med. 2023 Apr 03;61(9):1670-1675
pubmed: 36999398
JAMA Neurol. 2020 Sep 1;77(9):1079-1088
pubmed: 32589189
Euro Surveill. 2022 Nov;27(45):
pubmed: 36367013
Eur J Neurol. 2019 Jan;26(1):27-40
pubmed: 30300457
JAMA. 2022 Feb 15;327(7):639-651
pubmed: 35060999
Clin Neuropharmacol. 2010 Mar-Apr;33(2):91-101
pubmed: 20061941
Neurology. 2022 Feb 1;98(5):e541-e554
pubmed: 34810244
Sci Transl Med. 2024 Jan 24;16(731):eadk1599
pubmed: 38266109
J Neurol Sci. 2020 Nov 15;418:117147
pubmed: 32980780
Mult Scler. 2023 Jul;29(8):979-989
pubmed: 37431627
Neurol Neuroimmunol Neuroinflamm. 2022 May 6;9(4):
pubmed: 35523569
Ther Adv Neurol Disord. 2021 Apr 22;14:17562864211012835
pubmed: 34035836
Lancet. 2021 Jul 31;398(10298):385-387
pubmed: 34274038
Arthritis Rheumatol. 2022 Dec;74(12):1906-1915
pubmed: 35791921
Mult Scler Relat Disord. 2022 Nov;67:104079
pubmed: 35952457
J Neurol Neurosurg Psychiatry. 2023 Nov;94(11):934-937
pubmed: 37185261
Mult Scler Relat Disord. 2020 Oct;45:102420
pubmed: 32736217
Mult Scler Relat Disord. 2022 Mar;59:103682
pubmed: 35158189
Lancet Neurol. 2018 Feb;17(2):162-173
pubmed: 29275977
PLoS Pathog. 2023 Oct 5;19(10):e1011670
pubmed: 37796829
J Neurol Neurosurg Psychiatry. 2023 Apr;94(4):280-283
pubmed: 36564175
Lancet Infect Dis. 2024 Jul;24(7):e453-e462
pubmed: 38340735
N Engl J Med. 2022 Apr 21;386(16):1532-1546
pubmed: 35249272
Int J Mol Sci. 2023 May 10;24(10):
pubmed: 37239872
J Neurol Neurosurg Psychiatry. 2022 Sep;93(9):960-971
pubmed: 35835468
N Engl J Med. 2021 Dec 9;385(24):e84
pubmed: 34614326
Mult Scler Relat Disord. 2022 Jan;57:103371
pubmed: 35158435
J Neurol. 2022 Mar;269(3):1114-1120
pubmed: 34533590
Ann Intern Med. 2022 Dec;175(12):1693-1706
pubmed: 36215715
Mult Scler Relat Disord. 2022 Apr;60:103729
pubmed: 35334278
Mult Scler. 2023 Jul;29(8):990-1000
pubmed: 37431628
Lancet Infect Dis. 2023 Apr;23(4):421-434
pubmed: 36521506
Nat Med. 2021 Nov;27(11):1990-2001
pubmed: 34522051
JAMA Netw Open. 2023 Jun 1;6(6):e2319766
pubmed: 37351881
J Neurol Neurosurg Psychiatry. 2022 Sep;93(9):978-985
pubmed: 35193952
EBioMedicine. 2022 Jun;80:104042
pubmed: 35526306
Neurol Neuroimmunol Neuroinflamm. 2022 Nov 17;10(1):
pubmed: 36396447
Lancet. 2022 Apr 2;399(10332):1303-1312
pubmed: 35305296
Mult Scler Relat Disord. 2022 Jan;57:103382
pubmed: 35158475
J Neurol. 2023 Oct;270(10):4632-4639
pubmed: 37589743
JAMA Netw Open. 2023 May 1;6(5):e2310650
pubmed: 37133863
Neurology. 2021 Nov 9;97(19):e1870-e1885
pubmed: 34610987
Mult Scler Relat Disord. 2024 May;85:105547
pubmed: 38518506
JAMA. 2021 Feb 23;325(8):765-779
pubmed: 33620411
Nature. 2022 Feb;602(7898):676-681
pubmed: 35016198
Viruses. 2021 Apr 10;13(4):
pubmed: 33920222
Vaccines (Basel). 2023 Apr 03;11(4):
pubmed: 37112698
Front Immunol. 2023 May 24;14:1146704
pubmed: 37292210
Neurol Ther. 2022 Jun;11(2):759-762
pubmed: 35503396
Mult Scler Relat Disord. 2020 Jul;42:102180
pubmed: 32408155
Vaccines (Basel). 2022 Apr 28;10(5):
pubmed: 35632451
Int J Infect Dis. 2021 May;106:338-347
pubmed: 33864921