Design, Synthesis, and Evaluation of Oleyl-WRH Peptides for siRNA Delivery.
MDA-MB-231
RNA interference
SK-OV-3
STAT-3
Western blotting
acylation
arginine
breast cancer
cell-penetrating peptide
histidine
oleic acid
siRNA
tryptophan
Journal
Pharmaceuticals (Basel, Switzerland)
ISSN: 1424-8247
Titre abrégé: Pharmaceuticals (Basel)
Pays: Switzerland
ID NLM: 101238453
Informations de publication
Date de publication:
18 Aug 2024
18 Aug 2024
Historique:
received:
09
07
2024
revised:
31
07
2024
accepted:
16
08
2024
medline:
31
8
2024
pubmed:
31
8
2024
entrez:
29
8
2024
Statut:
epublish
Résumé
Delivering nucleic acid therapeutics across cell membranes is a significant challenge. Cell-penetrating peptides (CPPs) containing arginine (R), tryptophan (W), and histidine (H) show promise for siRNA delivery. To improve siRNA delivery and silence a model STAT3 gene, we hypothesized that oleyl acylation to CPPs, specifically (WRH)
Identifiants
pubmed: 39204188
pii: ph17081083
doi: 10.3390/ph17081083
pii:
doi:
Types de publication
Journal Article
Langues
eng