Degradation of andrographolide in Andrographis paniculata over 1 year storage.
Andrographis paniculata
HPLC
andrographolide
degradation
prolonged storage
Journal
Phytochemical analysis : PCA
ISSN: 1099-1565
Titre abrégé: Phytochem Anal
Pays: England
ID NLM: 9200492
Informations de publication
Date de publication:
28 Aug 2024
28 Aug 2024
Historique:
revised:
13
08
2024
received:
02
06
2024
accepted:
15
08
2024
medline:
31
8
2024
pubmed:
31
8
2024
entrez:
29
8
2024
Statut:
aheadofprint
Résumé
Andrographolide is a bioactive component found in the medicinal herb Andrographis paniculata (Burm. f.) Wall. ex Nees (Family-Acanthaceae) is well-known for its ability to cure liver disorders and as a bitter tonic. In this study, the rate of degradation of andrographolide was examined over the course of a year of storage. New and old (1-year storage) A. paniculata powder samples were used in the study. High-performance liquid chromatography (HPLC) was used to assess the concentration of andrographolide after its extraction using ethanol as the solvent. The findings demonstrated a 69.26% progressive deterioration of andrographolide over the storage period. Temperature and crystallinity are two factors that affect how quickly andrographolide degrades. The results emphasize how crucial it is to retain the effectiveness of A. paniculata extract by avoiding prolonged storage or by providing ideal storage conditions.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2024 John Wiley & Sons Ltd.
Références
Senthil Kumaran K, Thirugnanasambantham P, Viswanathan S, Sree M, Murthy R. An HPLC method for the estimation of andrographolide in rabbit serum, 2003. [Online]. Available: https://www.researchgate.net/publication/294271003
Rajani M, Shrivastava N, Ravishankara MN. A rapid method for isolation of andrographolide from Andrographis paniculata Nees (Kalmegh). Pharm Biol. 2000;38(3):204‐209. doi:10.1076/1388‐0209(200007)3831‐SFT204
Sharma S, Sharma YP, Bhardwaj C. HPLC quantification of andrographolide in different parts of Andrographis paniculata (Burm.f.) Wall. ex Nees. J Pharmacogn Phytochem. 2018;7(3):168‐171.
Syukri Y, Martien R, Lukitaningsih E, Nugroho AE. Quantification of andrographolide isolated from Andrographis paniculata Nees obtained from traditional market in Yogyakarta using validated HPLC. 2016.
Gajbhiye NA. Distribution pattern of andrographolide and total lactones in different parts of Kalmegh plant post harvest management of medicinal crops view project medicinal and aromatic plant research view project. 2010. [Online]. Available: https://www.researchgate.net/publication/280036434
Dai Y, Chen SR, Chai L, Zhao J, Wang Y, Wang Y. Overview of pharmacological activities of Andrographis paniculata and its major compound andrographolide. Crit Rev Food Sci Nutr. 2019;59:S17‐S29. doi:10.1080/10408398.2018.1501657
Pongtuluran OB, Rofaani E. Antiviral and immunostimulant activities of Andrographis paniculata. HAYATI J Biosci. 2015;22(2):67‐72. doi:10.4308/hjb.22.2.67
Murugan K, Selvanayaki K, Al‐Sohaibani S. Antibiofilm activity of Andrographis paniculata against cystic fibrosis clinical isolate Pseudomonas aeruginosa. World J Microbiol Biotechnol. 2011;27(7):1661‐1668. doi:10.1007/s11274‐010‐0620‐3
Rao PR, Rathod VK. Rapid extraction of andrographolide from Andrographis paniculata Nees by three phases partitioning and determination of its antioxidant activity. Biocatal Agric Biotechnol. 2015;4(4):586‐593. doi:10.1016/j.bcab.2015.08.016
Suriyo T, Chotirat S, Rangkadilok N, Pholphana N, Satayavivad J. Interactive effects of Andrographis paniculata extracts and cancer chemotherapeutic 5‐Fluorouracil on cytochrome P450s expression in human hepatocellular carcinoma HepG2 cells. J Herb Med. 2021;26:100421. doi:10.1016/j.hermed.2021.100421
Imani SF, Khairani AA, Arbianti R, Utami TS, Hermansyah H. The effect of fermentation time and sonication temperatures on extraction process of bitter leaves (Andrographis paniculata) against antidiabetic activity through α‐glucosidase enzyme inhibition test. AIP Conf Proc. 2020;2255. doi:10.1063/5.0015260
Jamaludin R, Mohd N, Safazliana R, Sulong R, Yaakob H. Andrographis paniculata‐loaded niosome for wound healing application: characterisation and in vivo analyses. J Drug Deliv Sci Technol. 2021;63:102427. doi:10.1016/j.jddst.2021.102427
Plubrukarn A, Pinsuwan S, Ingkatawornwong S, Supavita T. Stability of andrographolide in powdered andrographis herb under accelerated conditions. Planta Med. 2006;72(10):954‐956. doi:10.1055/s‐2006‐946696
USP 43, 2021: Vol. 5, Chapter <1225> Validation of compendial procedures. 8166–8171.
Lomlim L, Jirayupong N, Plubrukarn A. Heat‐accelerated degradation of solid‐state andrographolide. Chem Pharm Bull. 2003;51(1):24‐26. doi:10.1248/cpb.51.24