Selenium Nanoparticles Synergize with a KRAS Nanovaccine against Breast Cancer.
breast cancer
immunotherapy
nanoparticles
nanovaccines
selenium
Journal
Advanced healthcare materials
ISSN: 2192-2659
Titre abrégé: Adv Healthc Mater
Pays: Germany
ID NLM: 101581613
Informations de publication
Date de publication:
29 Aug 2024
29 Aug 2024
Historique:
revised:
05
08
2024
received:
25
04
2024
medline:
31
8
2024
pubmed:
31
8
2024
entrez:
29
8
2024
Statut:
aheadofprint
Résumé
Selenium (Se) is an element crucial for human health, known for its anticancer properties. Although selenium nanoparticles (SeNPs) have shown lower toxicity and higher biocompatibility than other Se compounds, bare SeNPs are unstable in aqueous solutions. In this study, several materials, including bovine serum albumin (BSA), chitosan, polymethyl vinyl ether-alt-maleic anhydride, and tocopherol polyethylene glycol succinate, are explored to develop stable SeNPs and further evaluate their potential as candidates for cancer treatment. All optimized SeNP are spherical, <100 nm, and with a narrow size distribution. BSA-stabilized SeNPs produced under acidic conditions present the highest stability in medium, plasma, and at physiological pH, maintaining their size ≈50-60 nm for an extended period. SeNPs demonstrate enhanced toxicity in cancer cell lines while sparing primary human dermal fibroblasts, underscoring their potential as effective anticancer agents. Moreover, the combination of BSA-SeNPs with a nanovaccine results in a strong tumor growth reduction in an EO771 breast cancer mouse model, demonstrating a three-fold decrease in tumor size. This synergistic anticancer effect not only highlights the role of SeNPs as effective anticancer agents but also offers valuable insights for developing innovative combinatorial approaches using SeNPs to improve the outcomes of cancer immunotherapy.
Identifiants
pubmed: 39205539
doi: 10.1002/adhm.202401523
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2401523Subventions
Organisme : HORIZON EUROPE Marie Sklodowska-Curie Actions
ID : 101103122
Organisme : 'la Caixa' Foundation
ID : LCF/PR/HR22/52420016
Organisme : 'la Caixa' Foundation
ID : LCF/PR/HR19/52160021
Organisme : Fundação para a Ciência e a Tecnologia
ID : UTAP-EXPL/NPN/0041/2021
Organisme : Fundação para a Ciência e a Tecnologia
ID : SFRH/BD/144851/2019
Organisme : Fundação para a Ciência e a Tecnologia
ID : PTDC/BTM-SAL/4350/2021
Organisme : Fundação para a Ciência e a Tecnologia
ID : UIDB/04138/2020
Organisme : Fundação para a Ciência e a Tecnologia
ID : UIDP/04138/2020
Organisme : Academy of Finland
ID : 331151
Organisme : UMCG Research Funds
Informations de copyright
© 2024 The Author(s). Advanced Healthcare Materials published by Wiley‐VCH GmbH.
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