Photodynamic therapy in management of cutaneous leishmaniasis: A systematic review.
Aminolevulinic acid
Laser therapy
Leishmania
Pentavalent antimonials
Photosensitizer
Journal
Lasers in medical science
ISSN: 1435-604X
Titre abrégé: Lasers Med Sci
Pays: England
ID NLM: 8611515
Informations de publication
Date de publication:
29 Aug 2024
29 Aug 2024
Historique:
received:
25
01
2024
accepted:
15
08
2024
medline:
31
8
2024
pubmed:
31
8
2024
entrez:
29
8
2024
Statut:
epublish
Résumé
This systematic review evaluated the efficacy and safety of photodynamic therapy (PDT) in the management of cutaneous leishmaniasis (CL). The electronic search for identification of relevant studies, adhered to the PICOS (Population, Intervention, Comparator, Outcomes and Study type) framework, was conducted through PubMed, Google scholar, Dimensions, X-mol, and Semantic Scholar till December 2023. All types of studies reporting PDT in the management of CL with no language restriction were included. Methodological quality appraised of the selected studies was performed using Jadad index. Of the 317 identified studies, 21 reported PDT for the treatment of CL lesions, consisting of two randomized controlled trials (RCTs), four single-center open study, one case series and 14 case reports. Collectively, these studies presented a total of 304 patients with ages ranging from 1 to 82 years, undergoing varying number of PDT sessions (3-28) and follow-up durations spanning 4 weeks to 24 months. The CL lesions predominantly manifested on the exposed body areas, such as face, limbs, neck, ear and nose, and characterized with the use of clinical variables, such as plaques, papules, erythema and ulceration. PDT protocols differed in the photosensitizer type, incubation time, light source characteristics (e.g., wavelength, output power, and energy density), duration of light illumination, number of PDT sessions and their respective frequencies. Treatment response was assessed through the clinical presentation (i.e., at the baseline and after PDT completion) or by the absence of Leishmania parasites. Adverse effects comprised of pain, burning and tingling sensation experienced during PDT, followed by erythema, pigmentation changes and edema post-treatment. This systematic review revealed that PDT is an efficacious and safe modality for the treatment of CL, with mild and transient side effects.
Identifiants
pubmed: 39207568
doi: 10.1007/s10103-024-04174-0
pii: 10.1007/s10103-024-04174-0
doi:
Substances chimiques
Photosensitizing Agents
0
Types de publication
Systematic Review
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
226Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature.
Références
Bailey MS, Lockwood DNJ (2007) Cutaneous leishmaniasis. Clin Dermatol 25(2):203–211
pubmed: 17350500
doi: 10.1016/j.clindermatol.2006.05.008
Elmahallawy EK, Martínez AS, Rodriguez-granger J, Hoyos- Y, Agil A, Marí J et al (2014) Diagnosis of leishmaniasis. J Infect Dev Ctries 8(8):961–972
pubmed: 25116660
doi: 10.3855/jidc.4310
Rogers ME, Ilg T, Nikolaev AV, Ferguson MAJ, Bates PA (2004) Transmission of cutaneous leishmaniasis by sand flies is enhanced by regurgitation of fPPG. Nature 430(6998):463–467
pubmed: 15269771
pmcid: 2835460
doi: 10.1038/nature02675
Peleva E, Walker SL (2020) Cutaneous leishmaniasis and health-related quality of life in returning travellers to the UK. J Travel Med. 27(7):taaa188
pubmed: 33145597
pmcid: 7883819
doi: 10.1093/jtm/taaa188
Modabber F, Buffet PA, Torreele E, Milon G, Croft SL (2007) Consultative meeting to develop a strategy for treatment of cutaneous leishmaniasis. Institute Pasteur, Paris. 13–15 June, 2006. Kinetoplastid Biol Dis 6:3
pubmed: 17456237
pmcid: 1868746
doi: 10.1186/1475-9292-6-3
De VHJC, Schallig HD (2022) Cutaneous Leishmaniasis : A 2022 Updated Narrative Review into Diagnosis and Management Developments. Am J Clin Dermatol 23(6):823–840
doi: 10.1007/s40257-022-00726-8
Desjeux P (2011) The increase in risk factors for leishmaniasis worldwide. Trans R Soc Trop Med Hyg 95(3):239–243
Alvar J, Vélez ID, Bern C, Herrero M, Desjeux P, Cano J et al (2012) Leishmaniasis worldwide and global estimates of its incidence. PLoS ONE 7(5):e35671
pubmed: 22693548
pmcid: 3365071
doi: 10.1371/journal.pone.0035671
Georgiadou SP, Makaritsis KP, Dalekos GN (2015) Leishmaniasis revisited: Current aspects on epidemiology, diagnosis and treatment. J Transl Intern Med 3(2):43–50
doi: 10.1515/jtim-2015-0002
Yesilova Y, Surucu HA, Ardic N, Aksoy M, Yesilova A, Oghumu S et al (2016) Meglumine antimoniate is more effective than sodium stibogluconate in the treatment of cutaneous leishmaniasis. J Dermatolog Treat 27:83–87
pubmed: 26105204
doi: 10.3109/09546634.2015.1054778
Bezemer JM, van der Ende J, Limpens J, de Vries HJC, Schallig HDFH (2021) Safety and efficacy of allylamines in the treatment of cutaneous and mucocutaneous leishmaniasis : A systematic review. PLoS ONE 16(4):e0249628
pubmed: 33826660
pmcid: 8026199
doi: 10.1371/journal.pone.0249628
Murray HW, Berman JD, Davies CR, Saravia NG (2005) Advances in leishmaniasis. Lancet 366(9496):1561–1577
pubmed: 16257344
doi: 10.1016/S0140-6736(05)67629-5
Nieto J, Alvar J, Mullen AB, Carter KC, Rodríguez C, San Andrés MI et al (2003) Pharmacokinetics, toxicities, and efficacies of sodium stibogluconate formulations after intravenous administration in animals. Antimicrob Agents Chemother 47(9):2781–2787
pubmed: 12936974
pmcid: 182616
doi: 10.1128/AAC.47.9.2781-2787.2003
Croft SL, Seifert K, Yardley V (2006) Current scenario of drug development for leishmaniasis. Indian J Med Res 123(3):399–410
pubmed: 16778319
Markle WH, Makhoul K (2004) Cutaneous leishmaniasis: Recognition and treatment. Am Fam Physician 69(6):1455–1460
pubmed: 15053410
Kevric I, Cappel MA, Keeling JH (2015) New world and old world leishmenia infections. A systematic review. Dermatol Clin 33(3):579–593
pubmed: 26143433
doi: 10.1016/j.det.2015.03.018
Al-Natour SH (2009) Update in the treatment of cutaneous leishmaniasis. J Fam Community Med 16(2):41–47
doi: 10.4103/2230-8229.96989
Zerpa O, Ulrich M, Blanco B, Polegre M, Avila A, Matos N et al (2007) Diffuse cutaneous leishmaniasis responds to miltefosine but then relapses. Br J Dermatol 156(6):1328–1335
pubmed: 17441955
doi: 10.1111/j.1365-2133.2007.07872.x
Minodier P, Parola P (2007) Cutaneous leishmaniasis treatment. Travel Med Infect Dis 5(3):150–158
pubmed: 17448941
doi: 10.1016/j.tmaid.2006.09.004
Lee Y, Baron ED (2011) Photodynamic therapy: Current evidence and applications in dermatology. Semin Cutan Med Surg 30(4):199–209
pubmed: 22123417
doi: 10.1016/j.sder.2011.08.001
Gardlo K, Horska Z, Enk CD, Rauch L, Megahed M, Ruzicka T et al (2003) Treatment of cutaneous leishmaniasis by photodynamic therapy. J Am Acad Dermatol 48(6):893–896
pubmed: 12789181
doi: 10.1067/mjd.2003.218
Chang KP, Kolli BK, Group L (2016) New, " light " for one-world approach toward safe and effective control of animal diseases and insect vectors from leishmaniac perspectives. Parasit Vectors 9:396
doi: 10.1186/s13071-016-1674-3
Din SZU, Ahmed K, Rengasamy KR, Gul N, Ahmad I (2023) Re: Efficacy of photodynamic therapy in cutaneous leishmaniasis: A systematic review. Photodiagnosis Photodyn Ther 45:103957
pubmed: 38161038
doi: 10.1016/j.pdpdt.2023.103957
Szeimies R-M, Morton CA, Sidoroff A, Braathen LR (2005) Photodynamic Therapy for Non-Melanoma Skin Cancer. Acta Derm Venereol 85(6):483–490
pubmed: 16396794
doi: 10.1080/00015550510044136
Li B, Lin L, Lin H, Wilson BC (2016) Photosensitized singlet oxygen generation and detection : Recent advances and future perspectives in cancer photodynamic therapy. J Biophotonics 11–12:1314–1325
doi: 10.1002/jbio.201600055
Van Der SEM, Robinson DJ, Van HJJ, Neumann HAM (2008) A review of photodynamic therapy in cutaneous leishmaniasis. J Eur Acad Dermatology Venereol 22(8):918–922
doi: 10.1111/j.1468-3083.2008.02805.x
Amir-Behghadami M, Janati A (2020) Population, Intervention, Comparison, Outcomes and Study (PICOS) design as a framework to formulate eligibility criteria in systematic reviews. Emerg Med J 37(6):387
pubmed: 32253195
doi: 10.1136/emermed-2020-209567
Moher D, Liberati A, Tetzlaff J, Altman DG, Academia and Clinic Annals of Internal Medicine (2009) Preferred Reporting Items for Systematic Reviews and Meta-Analyses. Ann Intern Med 151(4):264–269
pubmed: 19622511
doi: 10.7326/0003-4819-151-4-200908180-00135
Munn Z, Tufanaru C, Aromataris E (2014) JBI’s Systematic Reviews: Data Extraction and Synthesis. Am J Nurs 114(7):49–54
pubmed: 25742352
doi: 10.1097/01.NAJ.0000451683.66447.89
Asilian A, Davami M (2006) Comparison between the efficacy of photodynamic therapy and topical paromomycin in the treatment of Old World cutaneous leishmaniasis: A placebo-controlled, randomized clinical trial. Clin Exp Dermatol 31(5):634–637
pubmed: 16780497
doi: 10.1111/j.1365-2230.2006.02182.x
Khan K, Khan AU, Ghufran, Khan A, Khan M, Ahmad I (2020) Fractionated illumination improves the treatment outcomes of photodynamic therapy for. Photodiagnosis Photodyn Ther 29:101622
pubmed: 31866533
doi: 10.1016/j.pdpdt.2019.101622
Enk CD, Nasereddin A, Alper R, Jaffe CL, Wulf HC (2015) Cutaneous leishmaniasis responds to daylight-activated photodynamic therapy: Proof-of-concept for a novel self-administered therapeutic modality. Br J Dermatol 172(5):1364–1370
pubmed: 25363817
doi: 10.1111/bjd.13490
Burtness B, Harrington KJ, Greil R, Soulières D, Tahara M, de Castro G et al (2019) Pembrolizumab alone or with chemotherapy versus cetuximab with chemotherapy for recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-048): a randomised, open-label, phase 3 study. Lancet 394(10212):1915–1928
pubmed: 31679945
doi: 10.1016/S0140-6736(19)32591-7
Khan K, Khan AU, Gul B, Ullah A, Khan M, Ahmad I (2021) Photodynamic therapy for the treatment of cutaneous: a case series from Pakistan. Eur J Med Case Reports 5(7):203–208
doi: 10.24911/ejmcr/173-1606794043
Khan K, Khan AU, Ghufran, Ullah A, Khan M, Ahmad I (2020) Low-level laser therapy for the treatment of early stage cutaneous leishmaniasis: A pilot study. Dermatol Ther 33(6):e14232
doi: 10.1111/dth.14232
Ghaffarifar F, Jorjani O, Mirshams M, Miranbaygi MH, Hosseini ZK (2006) Photodynamic therapy as a new treatment of cutaneous leishmaniasis. East Mediterr Heal J 12(6):902–908
Sohl S, Kauer F, Paasch U, Simon JC, Wetzig T (2007) Photodynamic treatment of cutaneous leishmaniasis. JDDG J Ger Soc Dermatology 5(2):128–130
Khan A, Khan K, Biradar G, Khan M (2021) Treatment of cutaneous leishmaniasis with photodynamic therapy: The first case report from Khyber Pakhthunkhwa (KPK) Swat Pakistan. J Pakistan Assoc Dermatologists 31(1):120–124
Alamon-Reig F, Martí-Martí I, Loughlin CR-M, Garcia A, Carrera C, Aguilera-Peiró P (2022) Successful treatment of cutaneous leishmaniasis with photodynamic therapy. Indian J Dermatol Venereol Leprol 88(5):667–70
pubmed: 35962517
doi: 10.25259/IJDVL_1175_2021
Khan A, Ghufran, Khan K, Khan M, Ali J (2021) Treatment of multiple cutaneous leishmaniasis lesions in diabetic patient with photodynamic therapy. J Pakistan Assoc Dermatologists 31(4):716–9
Knapp C, Vaz L, Onoday H, Small A (2022) Dual treatment of cutaneous leishmaniasis with topical amphotericin B and photodynamic therapy in a pediatric patient. Pediatr Dermatol 39(5):761–763
pubmed: 35636952
doi: 10.1111/pde.15042
Pizinger K, Cetkovska P, Kacerovska D, Kumpova K (2009) Successful treatment of cutaneous leishmaniasis by photodynamic therapy and cryotherapy. Eur J Dermatology. 19(2):172–3
doi: 10.1684/ejd.2008.0587
Evangelou G, Krasagakis K, Giannikaki E, Kruger-krasagakis S, Tosca A (2011) Successful treatment of cutaneous leishmaniasis with intralesional aminolevulinic acid photodynamic therapy. Photodermatol Photoimmunol Photomed 27(5):254–256
pubmed: 21950631
doi: 10.1111/j.1600-0781.2011.00610.x
Marques E, Libanes HS (2011) Case report of photodynamic therapy failure in the treatment of cutaneous leishmaniasis: 24 months of clinical and histotologic follow-up. J Am Acad Dermatol 64(2 (Suppl. 1)):101
Fink C, Toberer F, Enk A, Gholam P (2016) Effective treatment of cutaneous leshmeniasis caused by Leishmenia tropica with topical photodynamic therapy. J Dtsch Dermatol Ges 14(8):836–838
Sainz-Gaspar L, Rosón E, Llovo J, Vázquez-Veiga H (2019) Photodynamic therapy in the treatment of cutaneous leishmaniasis. Actas Dermosifiliogr (Engl Ed) 110(3):249–251
Johansen MB, Jemec GBE, Fabricius S (2019) Effective treatment with photodynamic therapy of cutaneous leishmaniasis: A case report. Dermatol Ther 32(5):e13022
pubmed: 31306550
doi: 10.1111/dth.13022
Slape DRML, Kim ENY, Weller P, Gupta M (2019) Leishmenia tropica successfully treated with photodynamic therapy. Australas J Dermatol 60(1):e64–e65
pubmed: 29932205
doi: 10.1111/ajd.12862
Goldin H, Kohen S, Taxy J, Libman M, Cibull T (2020) Leishmania tropica infection of the ear treated with photodynamic therapy. JAAD Case Reports 6(6):514–517
pubmed: 32490113
pmcid: 7256222
doi: 10.1016/j.jdcr.2020.03.014
Khan MA, Aftab S, Shams N, Khan RU (2019) Efficacy of photodynamic therapy in the treatment of cutaneous leishmaniasis. Prof Med J 26(6):944–950
Slape DRM, Kim ENY, Weller P, Gupta M (2019) Leishmenia Tropica Successully Treated with Photodynamic Therapy. Australas J Dermatol. 60(1):e64-5
pubmed: 29932205
doi: 10.1111/ajd.12862
Khan K, Khan AU, Ghufran, Khan AU, Khan M, Ahmad I (2020) Low-level laser therapy for the treatment of early stage cutaneous leishmaniasis: A pilot study. Dermatol Ther. 33(6):e14232
doi: 10.1111/dth.14232
Fink C, Toberer F, Enk A, Gholam P (2016) Effective treatment of cutaneous leshmeniasis caused by Leishmenia tropica with topical photodynamic therapy. JDDG - J Ger Soc Dermatology 14(8):836–838
Fink C, Toberrer F, Enk A, Gholam P (2016) Effective treatment of cutaneous leishmaniasis caused by leishmenia tropica with topical photodynamic therapy. J Dtsch Dermatol. 14(8):836–8
doi: 10.1111/ddg.13082
Persheyev S, Samuel I, Smith T (2023) Organic and inorganic light emitting diodes for photodynamic therapy for cutaneous leishmaniasis. Glob J Infect Dis Clin Res 9(1):25–30
doi: 10.17352/2455-5363.000058
Allison RR, Moghissi K (2013) Photodynamic Therapy (PDT): PDT Mechanisms. Clin Endosc 46(1):24–29
pubmed: 23422955
pmcid: 3572346
doi: 10.5946/ce.2013.46.1.24
Salari S, Bamorovat M, Sharifi I, Almani PGN (2022) Global distribution of treatment resistance gene markers for leishmaniasis. J Clin Lab Anal 36(8):e24599
pubmed: 35808933
pmcid: 9396204
doi: 10.1002/jcla.24599
Cabral FV, Sabino CP, Dimmer JA, Sauter IP, Cortez MJ, Ribeiro MS (2020) Preclinical Investigation of Methylene Blue-mediated Antimicrobial Photodynamic Therapy on Leishmania Parasites Using Real-Time. Photochem Photobiol 96(13):604–610
pubmed: 31792979
doi: 10.1111/php.13188
Song D, Lindoso AL, Ph D, Oyafuso LK, Ph D, Cardoso L et al (2011) Photodynamic therapy using methylene blue to treat cutaneous leishmaniasis. Photomed Laser Surg 29(10):711–715
pubmed: 21671755
doi: 10.1089/pho.2010.2915
Mateus JE, Valdivieso W, Hernández IP (2014) Cell accumulation and antileishmanial effect of exogenous and endogenous protoporphyrin IX after photodynamic treatment. Biomedica 34:589–97
pubmed: 25504248
Berriman M, Renauld H, Bartholomeu DC, Lennard NJ, Caler E, Hamlin NE et al (2005) The Genome of the African Trypanosome Trypanosoma brucei. Science (80) 416(5733):416–22
doi: 10.1126/science.1112642
Akilov OE, Kosaka S, O’Riordan K, Hasan T (2007) Parasiticidal effect of delta-aminolevulinic acid-based photodynamic therapy for cutaneous leishmaniasis is indirect and mediated through the killing of the host cells. Exp Dermatol 16(8):651–660
pubmed: 17620092
doi: 10.1111/j.1600-0625.2007.00578.x
Evans S, Matthews W, Perry R, Fraker D, Norton J, Pass HI (1990) Effect of photodynamic therapy on tumor necrosis factor production by murine macrophages. J Natl Cancer Inst 82:34–39
pubmed: 2293654
doi: 10.1093/jnci/82.1.34
Gollnick SO, Evans SS, Baumann H, Owczarczak B, Maier P, Vaughan L et al (2003) Role of cytokines in photodynamic therapy-induced local and systemic inflammation. Br J Cancer 88:1772–1779
pubmed: 12771994
pmcid: 2377133
doi: 10.1038/sj.bjc.6600864
Souza DM, Alves PM, Silva MLF, Paulino TP, Coraspe HO, Mendonça MMS et al (2016) 5-ALA-mediated photodynamic therapy reduces the parasite load in mice infected with Leishmania braziliensis. Parasite Immunol 39(3):e12403
doi: 10.1111/pim.12403
Alexander J, Russell DG (1992) The Interaction of Leishmania Species with Macro phages. Adv Parasitol 31:175–254
pubmed: 1496927
doi: 10.1016/S0065-308X(08)60022-6
Juzeniene A, Juzenas P, Iani V, Moan J (2002) Topical Application of 5-Aminolevulinic Acid and its Methylester, Hexylester and Octylester Derivatives: Considerations for Dosimetry in Mouse Skin Model. Photochem Photobiol 76(3):329–334
pubmed: 12403455
doi: 10.1562/0031-8655(2002)076<0329:TAOAAA>2.0.CO;2
Ameen M (2010) Cutaneous and mucocutaneous leishmaniasis : emerging therapies and progress in disease management. Expert Opin Pharmacother 11:557–69
pubmed: 20163267
doi: 10.1517/14656560903555219
Robertson CA, Evans DH, Abrahamse H (2009) Photodynamic therapy (PDT): A short review on cellular mechanisms and cancer research applications for PDT. J Photochem Photobiol B 96(1):1–8
pubmed: 19406659
doi: 10.1016/j.jphotobiol.2009.04.001