Stress and Microglia: A Double-edged Relationship.
Bioenergetics
Cytokines
Microglia
Nutrition
Stress
Journal
Advances in neurobiology
ISSN: 2190-5215
Titre abrégé: Adv Neurobiol
Pays: United States
ID NLM: 101571545
Informations de publication
Date de publication:
2024
2024
Historique:
medline:
31
8
2024
pubmed:
31
8
2024
entrez:
29
8
2024
Statut:
ppublish
Résumé
Microglia are highly dynamic cells and acquire different activation states to modulate their multiple functions, which are tightly regulated by the central nervous system microenvironment in which they reside. In response to stress, that is to the appearance of non-physiological signals in their vicinity, microglia will adapt their function in order to promote a return to brain homeostasis. However, when these stress signals are chronically present, microglial response may not be adapted and lead to the establishment of a pathological state. The aim of this book chapter is to examine the substantial literature around the ability of acute and chronic stressors to affect microglial structure and function, with a special focus on psychosocial and nutritional stresses. We also discuss the molecular mechanisms known to date that explain the link between exposure to stressors and microglial activation.
Identifiants
pubmed: 39207700
doi: 10.1007/978-3-031-55529-9_18
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
333-342Informations de copyright
© 2024. The Author(s), under exclusive license to Springer Nature Switzerland AG.
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