Microglia in Neurodegenerative Diseases.
Alzheimer’s disease
Amyotrophic lateral sclerosis
Huntington’s disease
Infectious disease-associated neurodegeneration
Metal-precipitated neurodegeneration
Microglia
Nasu-Hakola disease
Neurodegeneration
Parkinson’s disease
Journal
Advances in neurobiology
ISSN: 2190-5215
Titre abrégé: Adv Neurobiol
Pays: United States
ID NLM: 101571545
Informations de publication
Date de publication:
2024
2024
Historique:
medline:
31
8
2024
pubmed:
31
8
2024
entrez:
29
8
2024
Statut:
ppublish
Résumé
Neurodegenerative diseases are manifested by a progressive death of neural cells, resulting in the deterioration of central nervous system (CNS) functions, ultimately leading to specific behavioural and cognitive symptoms associated with affected brain regions. Several neurodegenerative disorders are caused by genetic variants or mutations, although the majority of cases are sporadic and linked to various environmental risk factors, with yet an unknown aetiology. Neuroglial changes are fundamental and often lead to the pathophysiology of neurodegenerative diseases. In particular, microglial cells, which are essential for maintaining CNS health, become compromised in their physiological functions with the exposure to environmental risk factors, genetic variants or mutations, as well as disease pathology. In this chapter, we cover the contribution of neuroglia, especially microglia, to several neurodegenerative diseases, including Nasu-Hakola disease, Parkinson's disease, amyotrophic lateral sclerosis, Alzheimer's disease, Huntington's disease, infectious disease-associated neurodegeneration, and metal-precipitated neurodegeneration. Future research perspectives for the field pertaining to the therapeutic targeting of microglia across these disease conditions are also discussed.
Identifiants
pubmed: 39207709
doi: 10.1007/978-3-031-55529-9_27
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
497-512Informations de copyright
© 2024. The Author(s), under exclusive license to Springer Nature Switzerland AG.
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