Peripheral-derived regulatory T cells contribute to tumor-mediated immune suppression in a nonredundant manner.

Animals T-Lymphocytes, Regulatory / immunology Mice Kruppel-Like Transcription Factors / metabolism Male Mice, Inbred C57BL Immune Tolerance / immunology Humans
KLF2 melanoma pTregs prostate cancer regulatory T cells

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
03 Sep 2024
Historique:
medline: 31 8 2024
pubmed: 31 8 2024
entrez: 29 8 2024
Statut: ppublish

Résumé

Identifying tumor-mediated mechanisms that impair immunity is instrumental for the design of new cancer therapies. Regulatory T cells (Tregs) are a key component of cancer-derived immune suppression; however, these lymphocytes are necessary to prevent systemic autoimmunity in mice and humans, and thus, direct targeting of Tregs is not a clinical option for cancer patients. We have previously demonstrated that excising transcription factor Kruppel-like factor 2 (

Identifiants

DOI: 10.1073/pnas.2404916121 PMID: 39207730
pubmed: 39207730
doi: 10.1073/pnas.2404916121
doi:

Substances chimiques

Kruppel-Like Transcription Factors 0
Klf2 protein, mouse 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2404916121

Subventions

Organisme : NCI NIH HHS
ID : T32 CA009531
Pays : United States
Organisme : Elsa U. Pardee Foundation (EUPF)
ID : N/A
Organisme : NCI NIH HHS
ID : U01 CA196406
Pays : United States
Organisme : DOD | USA | MEDCOM | CDMRP | DOD Prostate Cancer Research Program (PCRP)
ID : PC140122
Organisme : NCI NIH HHS
ID : P30 CA022453
Pays : United States
Organisme : American Cancer Society (ACS)
ID : DBG-23-103670-01-IBCD

Déclaration de conflit d'intérêts

Competing interests statement:The authors declare no competing interest.

Auteurs

Md Moazzem Hossain (MM)

Department of Biochemistry, Microbiology and Immunology, Wayne State University Medical School, Detroit, MI 48201.

Paul King (P)

Department of Biochemistry, Microbiology and Immunology, Wayne State University Medical School, Detroit, MI 48201.

Justin Hackett (J)

Department of Oncology, Wayne State University Medical School, Detroit, MI 48201.
ORCID: 0000-0002-3377-1499

Herve C Gerard (HC)

Department of Biochemistry, Microbiology and Immunology, Wayne State University Medical School, Detroit, MI 48201.

Rajmund Niwinski (R)

Department of Biochemistry, Microbiology and Immunology, Wayne State University Medical School, Detroit, MI 48201.

Lan Wu (L)

Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232.
ORCID: 0000-0001-6032-083X

Luc Van Kaer (L)

Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232.
ORCID: 0000-0001-5275-2309

Gregory Dyson (G)

Department of Oncology, Wayne State University Medical School, Detroit, MI 48201.
Tumor Biology and Microenvironment Research Program, Barbara Ann Karmanos Cancer Institute, Detroit, MI 48201.

Heather Gibson (H)

Department of Biochemistry, Microbiology and Immunology, Wayne State University Medical School, Detroit, MI 48201.
Department of Oncology, Wayne State University Medical School, Detroit, MI 48201.
Tumor Biology and Microenvironment Research Program, Barbara Ann Karmanos Cancer Institute, Detroit, MI 48201.
ORCID: 0000-0003-2652-8252

Alexander D Borowsky (AD)

Department of Pathology and Laboratory Medicine, Center for Comparative Medicine, University of California Davis, Davis, CA 95616.
ORCID: 0000-0003-3117-9202

Eric Sebzda (E)

Department of Biochemistry, Microbiology and Immunology, Wayne State University Medical School, Detroit, MI 48201.
Tumor Biology and Microenvironment Research Program, Barbara Ann Karmanos Cancer Institute, Detroit, MI 48201.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Peripheral-derived regulatory T cells...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T régulateurs › Peripheral-derived regulatory T cells...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Peripheral-derived regulatory T cells...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription Krüppel-like › Peripheral-derived regulatory T cells...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Peripheral-derived regulatory T cells...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunomodulation › Tolérance immunitaire › Peripheral-derived regulatory T cells...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Peripheral-derived regulatory T cells...