Potassium dependent structural changes in the selectivity filter of HERG potassium channels.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
29 Aug 2024
29 Aug 2024
Historique:
received:
05
12
2023
accepted:
25
07
2024
medline:
31
8
2024
pubmed:
31
8
2024
entrez:
29
8
2024
Statut:
epublish
Résumé
The fine tuning of biological electrical signaling is mediated by variations in the rates of opening and closing of gates that control ion flux through different ion channels. Human ether-a-go-go related gene (HERG) potassium channels have uniquely rapid inactivation kinetics which are critical to the role they play in regulating cardiac electrical activity. Here, we exploit the K
Identifiants
pubmed: 39209832
doi: 10.1038/s41467-024-51208-w
pii: 10.1038/s41467-024-51208-w
pmc: PMC11362469
doi:
Substances chimiques
Potassium
RWP5GA015D
ERG1 Potassium Channel
0
Ether-A-Go-Go Potassium Channels
0
KCNH2 protein, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
7470Subventions
Organisme : Department of Education and Training | Australian Research Council (ARC)
ID : DP220103550
Organisme : Department of Education and Training | Australian Research Council (ARC)
ID : DP210102405
Organisme : Department of Health | National Health and Medical Research Council (NHMRC)
ID : APP1141974
Organisme : U.S. Department of Health & Human Services | NIH | Office of Extramural Research, National Institutes of Health (OER)
ID : 1R01GM150272
Organisme : Department of Education and Training | Australian Research Council (ARC)
ID : DP200102540
Organisme : Department of Health | National Health and Medical Research Council (NHMRC)
ID : APP1116948
Organisme : Department of Education and Training | Australian Research Council (ARC)
ID : DP170101732
Organisme : NIGMS NIH HHS
ID : R01 GM150272
Pays : United States
Informations de copyright
© 2024. The Author(s).
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